Neuroactive steroid pregnenolone sulphate inhibits long-term potentiation via activation of α2-adrenoreceptors at excitatory synapses in rat medial prefrontal cortex

International Journal of Neuropsychopharmacology

Volumn 11, Issue 5, 2008, Pages 611-624

  Wang, Ze Min ^a   Qi, Ying Jie ^a   Wu, Pei Ying ^a   Zhu, Yan ^a   Dong, Yan Lian ^a   Cheng, Zheng Xiang ^a   Zhu, Yan Hua ^a   Dong, Yi ^a   Ma, Lan ^a   Zheng, Ping ^a,b  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Long term potentiation (LTP); Medial prefrontal cortex (mPFC); Neuroactive steroid; Pregnenolone sulphate (PREGS)

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; ADENYLATE CYCLASE; ADENYLATE CYCLASE INHIBITOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; AZEPEXOLE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; HALOPERIDOL; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; N (2 PHENYLCYCLOPENTYL)AZACYCLOTRIDECAN 2 IMINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N METHYL DEXTRO ASPARTIC ACID; PREGNENOLONE SULFATE; YOHIMBINE;

ALPHA ADRENERGIC STIMULATION; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG MECHANISM; HIPPOCAMPUS; LONG TERM POTENTIATION; NEUROMODULATION; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SYNAPSE;

ADENYLATE CYCLASE; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; DRUG INTERACTIONS; ELECTRIC STIMULATION; ENZYME INHIBITORS; EXCITATORY POSTSYNAPTIC POTENTIALS; LONG-TERM POTENTIATION; N-METHYLASPARTATE; PREFRONTAL CORTEX; PREGNENOLONE; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; SYNAPSES;

EID: 46449103583     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145707008334     Document Type: Article

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