Combination of anorganic bovine-derived hydroxyapatite with binding peptide does not enhance bone healing in a critical-size defect in a rabbit model

Journal of Orthopaedic Research

Volumn 26, Issue 6, 2008, Pages 759-763

  Sarahrudi, Kambiz ^a   Mousavi, Mehdi ^b   Grossschmidt, Karl ^a   Sela, Nezir ^a   König, Franz ^a   Vécsei, Vilmos ^a   Aharinejad, Seyedhossein ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b DANUBE HOSPITAL   (Austria)

Author keywords

ABM P 15; Animal model; Fracture healing

Indexed keywords

ANORGANIC BOVINE DERIVED HYDROXYAPATITE P 15; OSSOPAN; UNCLASSIFIED DRUG; BIOMATERIAL; CELL BINDING PEPTIDE P 15; CELL-BINDING PEPTIDE P-15; COLLAGEN; HYDROXYAPATITE; PEPTIDE FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE DEVELOPMENT; BONE GRAFT; BONE PLATE; COMPARATIVE STUDY; CONTROLLED STUDY; CORTICAL BONE; FEMALE; FEMUR; FRACTURE HEALING; LONG BONE; MORPHOMETRICS; NONHUMAN; OSTEOTOMY; PRIORITY JOURNAL; ANIMAL; CATTLE; DISEASE MODEL; DRUG COMBINATION; FEMUR FRACTURE; MULTIMODALITY CANCER THERAPY; PROSTHESIS FAILURE; RABBIT; RADIOGRAPHY;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE PLATES; CATTLE; COLLAGEN; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; DURAPATITE; FEMALE; FEMORAL FRACTURES; OSTEOTOMY; PEPTIDE FRAGMENTS; PROSTHESIS FAILURE; RABBITS;

EID: 46449096754     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20527     Document Type: Article

References (37)

1. Fattah HA, Halaa EE, Shary THA. 1982. Nonunion of the humeral shaft: a report on 25 cases. Injury 14:225-262.
2. Foulk DA, Szabo RM. 1995. Diaphyseal humerus fractures natural history and occurrence of nonunion. Orthopaedics 18:333-335.
3. Healy WL, White GM, Mick CA, et al. 1987. Nonunion of humeral shaft. Clin Orthop 219:206-221.
4. Altner PC, Grana L, Gordon M. 1995. An experimental study on the significance of muscle tissue interposition on fracture healing. Clin Orthop 111:269-273.
5. Heiple KG, Herndon CH. 1965. The pathologic physiology of nonunion. Clin Orthop 43:11-21.
6. Hietaniemi K, Peltonen J, Paavolainen P. 1995. An experimental model for non-union in rats. Injury 26:681-686.
7. Farragos AF, Schemitsch EH, McKee MD. 1999. Complications of intramedullary nailing for fractures of humeral shaft. A review. J Orthop Trauma 13:258-267.
8. Hems TE, Bhullar TP. 1996. Interlocking nailing of humeral shaft fractures: the Oxford experience 1991 to 1994. Injury 27: 485-489.
9. Sarmiento A, McKellop H, Llinas A, et al. 1996 Effects of loading and fracture motion on diaphyseal tibial fractures. J Orthop Res 14:80-84.
10. Wiss DA, Johnson DL, Miao M. 1992. Compression plating for nonunion after failed external fixation of open tibial fractures. J Bone Joint Surg [Am] 74:1279-1285.
11. Rosson J, Simonis R. 1995. Locked nailing for the non union of the tibia. J Bone Joint Surg [Br] 74:358-361.
12. Wiss D, Stetson W. 1994. Nonunion of the tibia treated with a reamed intramedullary nail. J Orthop Trauma 8:189-194.
13. Chin KR, Nagarkatti DG, Mirando MA, et al. 2003. Salvage of distal tibia metaphyseal nonunions with the 90° cannulated blade plate. Clin Orthop Relat Res 409:241-249.
14. Wang J, Wenig L. 2003. Treatment of distal femoral nonunion with internal fixation, cortical allograft struts, and autogenous bone grafting. J Bone Joint Surg [Am] 85:436-440.
15. Abbott LC, Schottstaedt ER, Saunders JB, et al. 1947. The evaluation of cortical and cancellous bone as a grafting material. J Bone Joint Surg 29:381-414.
16. Heiple KG, Goldberg VM, Powell AE, et al. 1987. Biology of cancellous bone graft. Orthop Clin North Am 18:179-185.
17. Phemister D. 1947. Treatment of ununited fractures by only bone grafts without screw or tie fixation and without breaking down of the fibrous union. J Bone Joint Surg 29:946-960.
18. Burwell R. 1964. Studies in the transplantation of bone: VII. The fresh composite homograft-autograft of cancellous bone: an analysis of factors leading to osteogenesis in marrow transplants and in marrow containing bone grafts. J Bone Joint Surg [Br] 46:110-140.
19. Younger EM, Chapman MW. 1989. Morbidity at bone graft donor site. J Orthop Trauma 3:192-195.
20. Den Boer FC, Wippermann BW, Blokhuis TJ, et al. 2003. Healing of segmental bone defects with granular porous hydroxyapatite augmented with recombinant osteogenic protein-1 or autologous bone marrow. J Orthop Res 21:521-528.
21. Bhatnagar RS, Qian JJ, Gough CA. 1997. The role in cell binding of a betabend within the triple helical region in collagen al(I) chain: structural and biological evidence for conformational tautomerism on fiber surface. J Biomol Struct Dyn 14: 547-560.
22. Qian JJ, Bhatnagar RS. 1996. Enhanced cell attachment to anorganic bone mineral in the presence of a synthetic peptide related to collagen. J Biomed Mater Res 31:545-554.
23. Cheung SS, Tofe AJ. 1993. Mechanism of cell growth on calcium phosphate particles: role of cell-mediated dissolution of calcium phosphate matrix. STP Pharm Sci 3:51-55.
24. Callan DP, Rohrer MD. 1993. Use of bovine-derived hydroxyapatite in the treatment of edentulous ridge defects: a human clinical and histologic case report. J Periodontol 64: 575-582.
25. Zaner DJ, Yukna RA. 1984. Particle size of periodontal bone grafting materials. J Periodontol 55:406-409.
26. Yukna RA, Callan DP, Krauser JT, et al. 1998. Multi-center clinical evaluation of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) as a bone replacement graft material in human periodontal osseous defects. 6-months results. J Periodontol 69:655-663.
27. Yukna RA, Salinas TJ, Carr RF. 2002. Periodontal regeneration following use of ABM/p-15: a case report. Int J Periodontics Restorative Dent 22:146-155.
28. Bhatnagar RS, Qian JJ, Wedrychowska A, et al. 1999. Biomimetic habitat for cells: ordered matrix deposition and differentiation in gingival fibroblasts cultured on hydroxyapatite coated with a collagen analogue. Cell Mater 9:93-104.
29. Sadeghi M, Qian JJ, Richards DW, et al. 1993. A synthetic peptide promotes attachment of periodontal ligament fibroblasts to anorganic bone mineral. J Dent Res 72(Spec Issue): 391(Abstr 2299).
30. Bhatnagar RS, Quian JJ, Wedrychowska A, et al. 1999. Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen. Tissue Eng 5:53-65.
31. Bhatnagar RS, Qian JJ, Wedrychowska A, et al. 1999. Biomimetic habitats for cells: ordered matrix deposition and differentiation in gingival fibroblasts cultured on hydroxyapatite coated with a collagen analogue. Cells Mater 9:93-104.
32. Lallier TE, Yukna R, St Marie S, et al. 2001. The putative collagen binding peptide hastens periodontal ligament cell attachment to bone replacement graft materials. J Periodontol 72:990-997.
33. Krauser JT, Rohrer MD, Wallace SS. 2000. Human histologic and histomorphometric analysis comparing Osteograf/N with Pep- Gen P-15 in the maxillary sinus elevation procedure: a case report. Implant Dent 9:298-302.
34. Scarano A, Iezzi G, Petrone G, et al. 2003. Cortical bone regeneration with a synthetic cell-binding peptide: a histologic and histomorphometric pilot study. Implant Dent 12:318-324.
35. Cakmak G, Bolukbasi S, Simsek A, et al. 2006. Effect of synthetic cell-binding peptide on the healing of cortical segmental bone defects. Saudi Med J 27:777-780.
36. Bruder SP, Kraus KH, Goldberg VM, et al. 1998. The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg [Am] 80:985-996.
37. Johnson KD, Frierson KE, Keller TS, et al. 1996. Porous ceramics as bone graft substitute in long bone defects: a biomechanical, histological, and radiographic analysis. J Orthop Res 14:351-369.