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Volumn , Issue 10, 2008, Pages 1459-1462

A convenient one-pot synthesis of 7-trifluoromethyl-substituted imidazo [4,5-b] pyridines

Author keywords

Aminoimidazoles; Cyclizations; Fluorine; Heterocycles; Imidazopyridines

Indexed keywords

FLUORINE DERIVATIVE; IMIDAZOLE DERIVATIVE; METHYL GROUP; PYRIDINE DERIVATIVE;

EID: 46449096008     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1077794     Document Type: Article
Times cited : (11)

References (41)
  • 32
    • 46449127676 scopus 로고    scopus 로고
    • General Procedure A solution of amine 2a-i (5 mmol) in dried CH2Cl2 (2,5 mL) was heated until reflux. After a period of 15 min ethyl N-(cyanomethyl)formimidate 1 (5 mmol, 560 mg) was added under N2 counterflow. The mixture was allowed to stir under reflux for 2 h. To the hot reaction mixture the 1,3-biselectrophile of type 4a-e (5 mmol) was added. The mixture was stirred for 8 h. Then it was cooled down to ambient temperature. The crude product was worked up through flash column chromatography to obtain the product as white needles. Selected Data for 5o 1H NMR (400 MHz, CDCl3, δ, 3.79 (s, 3 H, OCH3, 5.47 (s, 2 H, CH2, 6.89 (m, 2 H, Ph, 7.33 (m, 2 H, Ph, 7.87 (s, 1 H, H-6, 8.31 (s, 1 H, H-2, 13C NMR (100 MHz, CDCl3, δ, 47.5 (OCH3, 55.3 (CH2, 111.5 (m, C-6, 122.3 q, 1JCF, 278 Hz, CF3
    • 3): δ = -62.59, -66.55.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.