Induction of cytotoxic T-lymphocytes and antitumor activity by a liposomal lipopeptide vaccine

Molecular Pharmaceutics

Volumn 5, Issue 3, 2008, Pages 464-471

  Chen, Weihsu ^a,b   Huang, Leaf ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Cancer immunotherapy; Cationic liposome; Cervical cancer; Lipopeptide; Vaccine

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; CANCER VACCINE; FATTY ACID; GAMMA INTERFERON; LIPOPEPTIDE; PROTEIN E7; SERINE;

ADOLESCENT; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DRUG FORMULATION; ENCAPSULATION; FEMALE; HUMAN PAPILLOMAVIRUS TYPE 16; IMMUNE RESPONSE; LIPOSOMAL DELIVERY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS TISSUE TUMOR; UTERINE CERVIX CANCER;

ANIMALS; CANCER VACCINES; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CELL TRANSFORMATION, VIRAL; FATTY ACIDS, MONOUNSATURATED; FEMALE; IMMUNOHISTOCHEMISTRY; LIPIDS; LIPOSOMES; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; ONCOGENE PROTEINS, VIRAL; QUATERNARY AMMONIUM COMPOUNDS; REPRESSOR PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, SUBUNIT;

EID: 46449085271     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp700126c     Document Type: Article

References (28)

1. Connor, J.; Huang, L. pH-sensitive immunoliposomes as an efficient and target-specific carrier for antitumor drugs. Cancer Res. 1986, 46(1), 3431-3435.
2. Felnerova, D.; Viret, J. F.; Gluck, R.; Moser, C. Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs. Curr. Opin. Biotechnol. 2004, 15 (6), 518-529.
3. Li, S. D.; Huang, L. Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells. Mol. Pharmaceutics 2006, 3 (5), 579-588.
4. Malik, D. K.; Baboota, S.; Ahuja, A.; Hasan, S.; Ali, J. Recent advances in protein and peptide drug delivery systems. Curr. Drug Deliv. 2007, 4 (2), 141-151.
5. Cui, Z.; Huang, L. Liposome-polycation-DNA (LPD) particle as a carrier and adjuvant for protein-based vaccines: therapeutic effect against cervical cancer. Cancer Immunol. Immunother. 2005, 54 (12), 1180-1190.
6. Dileo, J.; Banerjee, R.; Whitmore, M.; Nayak, J. V.; Falo, L. D., Jr.; Huang, L. Lipid-protamine-DNA-mediated antigen delivery to antigen-presenting cells results in enhanced anti-tumor immune responses. Mol. Ther. 2003, 7 (5 Pt 1), 640-648.
7. Alving, C. R. Design and selection of vaccine adjuvants: animal models and human trials. Vaccine 2002, 20 (3), S56-64.
8. Chen, W. C.; Huang, L. Non-viral vector as vaccine carrier. Adv. Genet. 2005, 54, 315-337.
9. Chen, W.; Yan, W.; Huang, L., A simple but effective cancer vaccine consisting of an antigen and a cationic lipid. Cancer Immunol. Immunother. 2007, in press.
10. Yan, W.; Chen, W.; Huang, L. Mechanism of adjuvant activity of cationic liposome: phosphorylation of a MAP kinase, ERK and induction of chemokines. Mol. Immunol. 2007, 44 (15), 3672-3681.
11. Gahery-Segard, H.; Pialoux, G.; Charmeteau, B.; Sennet, S.; Poncelet, H.; Raux, M.; Tartar, A.; Levy, J. P.; Gras-Masse, H.; Guillet, J. G. Multiepitopic B- and T-cell responses induced in humans by a human immunodeficiency virus type 1 lipopeptide vaccine. J. Virol. 2000, 74 (4), 1694-1703.
12. Pialoux, G.; Gahery-Segard, H.; Sermet, S.; Poncelet, H.; Fournier, S.; Gerard, L.; Tartar, A.; Gras-Masse, H.; Levy, J. P.; Guillet, J. G. Lipopeptides induce cell-mediated anti-HIV immune responses in seronegative volunteers. AIDS 2001, 75 (10), 1239-1249.
13. Livingston, B. D.; Crimi, C.; Grey, H.; Ishioka, G.; Chisari, F. V.; Fikes, J.; Grey, H.; Chesnut, R. W.; Sette, A. The hepatitis B virus-specific CTL responses induced in humans by lipopeptide vaccination are comparable to those elicited by acute viral infection. J. Immunol. 1997, 159 (3), 1383-1392.
14. BenMohamed, L.; Gras-Masse, H.; Tartar, A.; Daubersies, P.; Brahimi, K.; Bossus, M.; Thomas, A.; Druilhe, P. Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees. Eur. J. Immunol. 1997, 27 (5), 1242-1253.
15. Kanafani, Z. A.; Corey, G. R. Daptomycin: a rapidly bactericidal lipopeptide for the treatment of Gram-positive infections. Expert Rev. Anti Infect. Then 2007, 5 (2), 177-184.
16. Denning, D. W.; Marr, K. A.; Lau, W. M.; Facklam, D. P.; Ratanatharathorn, V.; Becker, C.; Ullmann, A. J.; Seibel, N. L.; Flynn, P. M.; van Burik, J. A.; Buell, D. N.; Patterson, T. F. Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosis. J. Infect. 2006, 55 (5), 337-349.
17. Byers, A. M.; Kemball, C. C.; Moser, J. M.; Lukacher, A. E. Cutting edge: rapid in vivo CTL activity by polyoma virus-specific effector and memory CD8+ T cells. J. Immunol. 2003, 171 (1), 17-21.
18. Melief, C. J. Tumor eradication by adoptive transfer of cytotoxic T lymphocytes. Adv. Cancer Res. 1992, 58, 143-175.
19. Melief, C. J.; Van Der Burg, S. H.; Toes, R. E.; Ossendorp, F.; Offringa, R. Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes. Immunol. Rev. 2002, 188, 177-182.
20. Feltkamp, M. C.; Smits, H. L.; Vierboom, M. P.; Minnaar, R. P.; de Jongh, B. M.; Drijfhout, J. W.; ter Schegget, J.; Melief, C. J.; Kast, W. M. Vaccination with cytotoxic T lymphocyte epitopecontaining peptide protects against a tumor induced by human papillomavirus type 16-transformed cells. Eur. J. Immunol. 1993, 23 (9), 2242-2249.
21. Fernandes, I.; Frisch, B.; Muller, S.; Schuber, F. Synthetic lipopeptides incorporated in liposomes: in vitro stimulation of the proliferation of murine splenocytes and in vivo induction of an immune response against a peptide antigen. Mol. Immunol. 1997, 34 (8-9), 569-576.
22. Yagi, N.; Ogawa, Y.; Kodaka, M.; Okada, T.; Tomohiro, T.; Konakahara, T.; Okuno, H. Preparation of functional liposomes with peptide ligands and their binding to cell membranes. Lipids 2000, 35 (6), 673-680.
23. Liang, M. T.; Davies, N. M.; Toth, I. Encapsulation of lipopeptides within liposomes: effect of number of lipid chains, chain length and method of liposome preparation. Int. J. Pharm. 2005, 301 (1-2), 247-254.
24. Verheul, A. F.; Udhayakumar, V.; Jue, D. L.; Wohlhueter, R. M.; Lal, A. A. Monopalmitic acid-peptide conjugates induce cytotoxic T cell responses against malarial epitopes: importance of spacer amino acids. J. Immunol. Methods 1995, 182 (2), 219-226.
25. Schild, H.; Deres, K.; Wiesmuller, K. H.; Jung, G.; Rammensee, H. G. Efficiency of peptides and lipopeptides for in vivo priming of virus-specific cytotoxic T cells. Eur. J. Immunol. 1991, 21 (11), 2649-2654.
26. Wiesmuller, K. H.; Bessler, W. G.; Jung, G. Solid phase peptide synthesis of lipopeptide vaccines eliciting epitope-specific B-, T-helper and T-killer cell response. Int. J. Pept. Protein Res. 1992, 40 (3-4), 255-260.
27. da Fonseca, D. P.; Joosten, D.; van der Zee, R.; Jue, D. L.; Singh, M.; Vordermeier, H. M.; Snippe, H.; Verheul, A. F. Identification of new cytotoxic T-cell epitopes on the 38-kilodalton lipoglyco-protein of Mycobacterium tuberculosis by using lipopeptides. Infect. Immun. 1998, 66 (7), 3190-3197.
28. Ljunggren, H. G.; Stam, N. J.; Ohlen, C.; Neefjes, J. J.; Hoglund, P.; Heemels, M. T.; Bastin, J.; Schumacher, T. N.; Townsend, A.; Karre, K. Empty MHC class I molecules come out in the cold. Nature 1990, 346 (6283), 476-480.