Expression profiling using tissue microarray in 211 malignant fibrous histiocytomas confirms the prognostic value of Ki-67

Virchows Archiv

Volumn 445, Issue 3, 2004, Pages 224-230

  Engellau, Jacob ^a   Persson, Annette ^b   Bendahl, Pär Ola ^a   Åkerman, Måns ^b   Domanski, Henryk A ^b   Bjerkehagen, Bodil ^c   Lilleng, Peer ^d   Weide, Johan ^e   Rydholm, Anders ^b   Alvegård, Thor A ^a   Nilbert, Mef ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Ki 67; Malignant fibrous histiocytoma; Prognosis; Soft tissue sarcoma; Tissue microarray

Indexed keywords

CYCLIN A; GLYCOPROTEIN P; HERMES ANTIGEN; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN P53; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER RECURRENCE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MALIGNANT FIBROUS HISTIOCYTOMA; METASTASIS; MITOSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN MICROARRAY; SOFT TISSUE SARCOMA; TUMOR NECROSIS; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD44; CYCLIN A; FEMALE; GENE EXPRESSION PROFILING; HISTIOCYTOMA, BENIGN FIBROUS; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; SOFT TISSUE NEOPLASMS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 4644371703     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-004-1065-6     Document Type: Article

References (44)

1. Bauer HC, Trovik CS, Alvegard TA, Berlin O, Erlanson M, Gustafson P, Klepp R, Moller TR, Rydholm A, Saeter G, Wahlstrom O, Wiklund T (2001) Monitoring referral and treatment in soft tissue sarcoma: study based on 1,851 patients from the Scandinavian Sarcoma Group Register. Acta Orthop Scand 72:150-159
2. Choong PF, Akerman M, Willen H, Andersson C, Gustafson P, Baldetorp B, Ferno M, Alvegard T, Rydholm A (1994) Prognostic value of Ki-67 expression in 182 soft tissue sarcomas. Proliferation - a marker of metastasis? APMIS 102:915-924
3. Coindre JM, Terrier P, Bui NB, Bonichon F, Collin F, Le Doussal V, Mandard AM, Vilain MO, Jacquemier J, Duplay H, Sastre X, Barlier C, Henry-Amar M, Mace-Lesech J, Contesso G (1996) Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group. J Clin Oncol 14:869-877
4. Dan'ura T, Kawai A, Morimoto Y, Naito N, Yoshida A,Inoue H (2002) Apoptosis and expression of its regulatory proteins in soft tissue sarcomas. Cancer Lett 178:167-174
5. Deyrup AT, Haydon RC, Huo D, Ishikawa A, Peabody TD, He TC, Montag AG (2003) Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases. Cancer 98:805-813
6. Drobnjak M, Latres E, Pollack D, Karpeh M, Dudas M, Woodruff JM, Brennan MF, Cordon-Cardo C (1994) Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas. J Natl Cancer Inst 86:549-554
7. Engellau J, Akerman M, Anderson H, Domanski HA, Rambech E, Alvegard TA, Nilbert M (2001) Tissue microarray technique in soft tissue sarcoma: immunohistochemical Ki-67 expression in malignant fibrous histiocytoma. Appl Immunohistochem Mol Morphol 9:358-363
8. Fletcher CD (1992) Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma. Am J Surg Pathol 16:213-228
9. Fletcher CD, Gustafson P, Rydholm A, Willen H, Akerman M (2001) Clinicopathologic re-evaluation of 100 malignant fibrous histiocytomas: prognostic relevance of subclassification. J Clin Oncol 19:3045-3050
10. Fletcher CDM, Unni KK, Mertens FE (2002) Pathology and genetics of tumours of soft tissue and bone. World Health Organisation classification of tumours. Fletcher CDM, Unni KK, Mertens F (ed) IARC Press, Lyon
11. Gustafson P (1994) Soft tissue sarcoma. Epidemiology and prognosis in 508 patients. Acta Orthop Scand Suppl 259:1-31
12. Gustafson P, Akerman M, Alvegard TA, Coindre JM, Fletcher CD, Rydholm A, Willen H (2003) Prognostic information in soft tissue sarcoma using tumour size, vascular invasion and microscopic tumour necrosis-the SIN-system. Eur J Cancer 39:1568-1576
13. Hasegawa T, Yokoyama R, Lee YH, Shimoda T, Beppu Y,Hirohashi S (2000) Prognostic relevance of a histological grading system using MIB-1 for adult soft-tissue sarcoma. Oncology 58:66-74
14. Hasegawa T, Yamamoto S, Yokoyama R, Umeda T, Matsuno Y, Hirohashi S (2002) Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer 95:843-851
15. Heslin MJ, Cordon-Cardo C, Lewis JJ, Woodruff JM, Brennan MF (1998) Ki-67 detected by MIB-1 predicts distant metastasis and tumor mortality in primary, high grade extremity soft tissue sarcoma. Cancer 83:490-497
16. Hoos A, Stojadinovic A, Mastorides S, Urist MJ, Polsky D, Di Como CJ, Brennan MF, Cordon-Cardo C (2001) High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomas. Cancer 92:869-874
17. Hoos A, Urist MJ, Stojadinovic A, Mastorides S, Dudas ME, Leung DH, Kuo D, Brennan MF, Lewis JJ, Cordon-Cardo C (2001) Validation of tissue microarrays for immunohistochemical profiling of cancer specimens using the example of human fibroblastic tumors. Am J Pathol 158:1245-1251
18. Huuhtanen RL, Blomqvist CP, Bohling TO, Wiklund TA, Tukiainen EJ, Virolainen M, Tribukait B,Andersson LC (1999) Expression of cyclin A in soft tissue sarcomas correlates with tumor aggressiveness. Cancer Res 59:2885-2890
19. Jensen V, Sorensen FB, Bentzen SM, Ladekarl M, Nielsen OS, Keller J, Jensen OM (1998) Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas: a retrospective immunohistological study including 216 soft tissue sarcomas. Histopathology 32:536-546
20. Kahara N, Ozaki T, Doi T, Nishida K, Kawai A, Shibahara M,Inoue H (2000) CD44 expression in soft tissue sarcomas. Virchows Arch 436:574-578
21. Kallioniemi OP, Wagner U, Kononen J, Sauter G (2001) Tissue microarray technology for high-throughput molecular profiling of cancer. Hum Mol Genet 10:657-662
22. Kempson RL, Evans HL, Hendrickson MR, Sibley RK (2001) Tumors of the soft tissues. Vol. Third series. Armed Forces Institute of Pathology, Washington D.C.
23. Kindblom LG, Widehn S, Meis-Kindblom JM (2003) The role of electron microscopy in the diagnosis of pleomorphic sarcomas of soft tissue. Semin Diagn Pathol 20:72-81
24. Kononen J, Bubendorf L, Kallioniemi A, Barlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP (1998) Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 4:844-847
25. Levine EA, Holzmayer T, Bacus S, Mechetner E, Mera R, Bolliger C, Roninson IB, Das Gupta TK (1997) Evaluation of newer prognostic markers for adult soft tissue sarcomas. J Clin Oncol 15:3249-3257
26. Maula S, Huuhtanen RL, Blomqvist CP, Wiklund TA, Laurila P, Ristamaki R (2001) The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas. Br J Cancer 84:244-252
27. Meis-Kindblom JM, Bjerkehage B, Bohling T, Domanski H, Halvorsen TB, Larsson O, Lilleng P, Myhre-Jensen O, Stenwig E, Virolainen M, Willen H, Akerman M, Kindblom LG (1999) Morphologic review of 1000 soft tissue sarcomas from the Scandinavian Sarcoma Group (SSG) Register. The peer-review committee experience. Acta Orthop Scand Suppl 285:18-26
28. Mentzel T, Calonje E, Wadden C, Camplejohn RS, Beham A, Smith MA, Fletcher CD (1996) Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. Am J Surg Pathol 20:391-405
29. Miettinen M (2003) Diagnostic soft tissue pathology, 1st edn. Churchill Livingstone, Philadelphia
30. Miettinen M, Sarlomo-Rikala M,Kovatich AJ (1998) Cell-type- and tumour-type-related patterns of bcl-2 reactivity in mesenchymal cells and soft tissue tumours. Virchows Arch 433:255-260
31. Nakanishi H, Myoui A, Ochi T,Aozasa K (1997) P-glycoprotein expression in soft-tissue sarcomas. J Cancer Res Clin Oncol 123:352-356
32. Nielsen TO, Hsu FD, O'Connell JX, Gilks CB, Sorensen PH, Linn S, West RB, Liu CL, Botstein D, Brown PO, van de Rijn M (2003) Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology. Am J Pathol 163:1449-1456
33. Noguchi T, Dobashi Y, Minehara H, Itoman M, Kameya T (2000) Involvement of cyclins in cell proliferation and their clinical implications in soft tissue smooth muscle tumors. Am J Pathol 156:2135-2147
34. Oda Y, Tamiya S, Oshiro Y, Hachitanda Y, Kinukawa N, Iwamoto Y, Tsuneyoshi M (2002) Reassessment and clinicopathological prognostic factors of malignant fibrous histiocytoma of soft parts. Pathol Int 52:595-606
35. Pakos EE, Ioannidis JP (2003) The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis. Cancer 98:581-589
36. Pezzi CM, Rawlings MS Jr, Esgro JJ, Pollock RE, Romsdahl MM (1992) Prognostic factors in 227 patients with malignant fibrous histiocytoma. Cancer 69:2098-2103
37. Pisters PW, Pollock RE (1999) Staging and prognostic factors in soft tissue sarcoma. Semin Radiat Oncol 9:307-314
38. Reid AH, Tsai MM, Venzon DJ, Wright CF, Lack EE, O'Leary TJ (1996) MDM 2 amplification, P53 mutation, and accumulation of the P53 gene product in malignant fibrous histiocytoma. Diagn Mol Pathol 5:65-73
39. Salo JC, Lewis JJ, Woodruff JM, Leung DH, Brennan MF (1999) Malignant fibrous histiocytoma of the extremity. Cancer 85:1765-1772
40. Stojadinovic A, Leung DH, Allen P, Lewis JJ, Jaques DP, Brennan MF (2002) Primary adult soft tissue sarcoma: time-dependent influence of prognostic variables. J Clin Oncol 20:4344-4352
41. Weiss SW, et al. (2001) Enzinger and Weiss's soft tissue tumors, 4th edn. Strauss M. (ed) C.V. Mosby Co, St. Louis
42. Wurl P, Meye A, Lautenschlager C, Schmidt H, Bache M, Kalthoff H, Schonfelder M, Rath FW, Taubert H (1999) Clinical relevance of pRb and p53 co-overexpression in soft tissue sarcomas. Cancer Lett 139:159-165
43. Yang P, Hirose T, Hasegawa T, Seki K, Sano T, Hizawa K (1995) Prognostic implication of the p53 protein and Ki-67 antigen immunohistochemistry in malignant fibrous histiocytoma. Cancer 76:618-625
44. Zagars GK, Ballo MT, Pisters PW, Pollock RE, Patel SR, Benjamin RS, Evans HL (2003) Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy: an analysis of 225 patients. Cancer 97:2530-2543