Micro parallel liquid chromatography: Enabling technology for discovery analytical chemistry

Assay and Drug Development Technologies

Volumn 2, Issue 4, 2004, Pages 389-395

  Lemmo, Anthony V ^a   Hobbs, Steve ^b,c   Patel, Paren ^b  

^a Entevis Inc   (United States)

^b Nanostream Inc   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

WATER;

ANALYTIC METHOD; ARTICLE; ASSAY; CHEMICAL ANALYSIS; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DRUG TARGETING; INSTRUMENTATION; LIQUID CHROMATOGRAPHY; MOLECULAR LIBRARY; PRODUCTIVITY; SAMPLE SIZE; SOLUBILITY;

CHEMISTRY, ANALYTICAL; CHROMATOGRAPHY, LIQUID;

EID: 4644345208     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2004.2.389     Document Type: Article

References (9)

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2. Lee MS: LC/MS Applications in Drug Development. Wiley Publishers, Hoboken, NJ, 2002.
3. Greig M. Use of automated HPLC-MS analysis for monitoring and improving the purity of combinational libraries. Am Lab 1999;31:28-32.
4. Lemmo AV, Olbert C, Haley S: Multiplex HPLC analysis in support of high-throughput combinatorial formulation development: keeping pace with 15,000 samples per week. 14th International Symposium on Pharmaceutical and Biomedical Analysis, Orlando, FL, September 16, 2003.
5. Wishnies SM, Olbert C, Nishimura M, Lemmo AV, Kohno Y: HPLC 2003, Nice, France, June 18, 2003.
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7. Mirrless MS, Moulton SJ, Murphy CT, Taylor PJ: Direct measurement of octanol water partition coefficients by high-pressure liquid chromatography. J Med Chem 1976; 19:615-619.
8. Lombardo F, Shalaeva MY, Tupper KA, Gao F, Abraham MH: ElogPoct: a tool for lipophilicity determination in drug discovery. J Med Chem 2000;43:2922-2928.
9. Valko K, Bevan C, Reynolds D: Chromatographic hydrophobicity index by fast-gradient RP-HPLC: a high-throughput alternative to log P/log D. Anal Chem 1997;69:2022-2029.