Flunarizine effects on oxidative stress in migraine patients

Cephalalgia

Volumn 24, Issue 7, 2004, Pages 528-532

  Ciancarelli, I ^a   Tozzi Ciancarelli, M G ^a   Di Massimo, C ^a   Marini, C ^a   Carolei, A ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Flunarizine; Lipid peroxidation by products; Migraine; Nitric oxide

Indexed keywords

ANTIMIGRAINE AGENT; FLUNARIZINE; NITRATE; NITRIC OXIDE; NITRITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG EFFECT; FEMALE; HUMAN; LIPID PEROXIDATION; MALE; MIGRAINE; OXIDATIVE STRESS; URINALYSIS; URINE LEVEL; VASODILATATION;

ADULT; FEMALE; FLUNARIZINE; HUMANS; MALE; MIDDLE AGED; MIGRAINE WITHOUT AURA; NITRIC OXIDE; OXIDATIVE STRESS; STATISTICS, NONPARAMETRIC; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 4644334245     PISSN: 03331024     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1468-2982.2003.00705.x     Document Type: Article

References (35)

1. Silberstein SD, Goadsby PJ. Migraine: preventive treatment. Cephalalgia 2002; 22:491-512.
2. Goadsby PJ, Lipton RB, Ferrari MD. Migraine - current understanding and treatment. N Engl J Med 2002; 346:257-70.
3. Ayajiki K, Okamura T, Toda N. Flunarizine, an antimigraine agent impairs nitroxidergic nerve function in cerebral arteries. Eur J Pharmacol 1997; 329:49-53.
4. 2+ channel blockers lidoflazide and flunarizine. Neurosci Lett 1993; 158:97-100.
5. Olesen J, Jansen-Olesen I. Nitric oxide mechanisms in migraine. Pathol Biol (Paris) 2000; 48:648-57.
6. Olesen J, Thomsen LL, Iversen HK. Nitric oxide is a key molecule in migraine and other vascular headaches. Trends Pharmacol Sci 1994; 15:149-53.
7. Goadsby PJ, Edvinsson L. The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol 1993; 33:48-56.
8. Bredt DS. Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radic Res 1999; 31:577-96.
9. Strassman AM, Raymond SA, Burstein R. Sensitization of meningeal sensory neurons and the origin of headaches. Nature 1996; 384:560-4.
10. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87:1620-4.
11. Wei EP, Kontos HA, Beckman JS. Mechanisms of cerebral vasodilation by superoxide, hydrogen peroxide, and peroxynitrite. Am J Physiol 1996; 271:H1262-6.
12. Halliwell B. Reactive oxygen species and the central nervous system. J Neurochem 1992; 59:1609-23.
13. Kontos HA. Oxygen radicals in cerebral ischemia. The 2001 Willis Lecture. Stroke 2001; 32:2712-6.
14. Welch KM, Nagesh V, Aurora SK, Gelman N. Periaque-ductal gray matter dysfunction in migraine: cause or the burden of illness? Headache 2001; 41:629-37.
15. Ciancarelli I, Tozzi-Ciancarelli MG, Di Massimo C, Marini C, Carolei A. Urinary nitric oxide metabolites and lipid peroxidation by-products in migraine. Cephalalgia 2003; 23:39-42.
16. Benkusky NA, Lewis SJ, Kooy NW. Attenuation of vascular relaxation after development of tachyphylaxis to peroxynitrite. Am J Physiol 1998; 275:H501-8.
17. Kubo K, Yoshitake I, Kumada Y, Shuto K, Nakamizo N. Radical scavenging action of flunarizine in rat brain in vitro. Arch Int Pharmacodyn Ther 1984; 272:283-95.
18. Somova L, Dashev G, Kirilov G, Nikolov R, Doncheva M, Vassileva M. Streptozotocin-induced diabetes in rat. Antioxidant protection of vascular complications by flunarizine and aligeron. Meth Find Exp Clin Pharmacol 1989; 11:607-12.
19. Takei M, Hiramatsu M, Mori A. Inhibitory effects of calcium antagonists on mitochondrial swelling induced by lipid peroxidation or arachidonic acid in the rat brain. Neurochem Res 1994; 19:1199-206.
20. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998; 50:466-70.
21. Kurioka S, Koshimura K, Sugitani M, Murakami Y, Nishiki M, Kato Y. Analysis of urinary nitric oxide metabolites in healthy subjects. Endocrine J 1999; 46:421-8.
22. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias, and facial pain. Cephalalgia 1988; 8 (Suppl. 7):1-96.
23. Ciancarelli I, Di Massimo C, Tozzi-Ciancarelli MG, De Matteis G, Marini C, Carolei A. Helicobacter pylori infection and migraine. Cephalalgia 2002; 22:222-5.
24. Suntres ZE, Omri A, Shek PN. Pseudomonas aeruginosa-induced lung injury: role of oxidative stress. Microb Pathog 2002; 32:27-34.
25. Wang J, Brown MA, Tam SH, Chan MC, Whitworth JA. Effects of diet on measurement of nitric oxide metabolites. Clin Exp Pharmacol Physiol 1997; 24:418-20.
26. Grisham MB, Johnson GG, Lancaster JR Jr. Quantitation of nitrate and nitrite in extracellular fluids. Methods Enzymol 1996; 268:237-16.
27. Misko TP, Schilling RJ, Salvemini D, Moore WM, Currie MG. A fluorometric assay for the measurement of nitrite in biological samples. Anal Biochem 1993; 214:11-6.
28. Meydani M, Evans WJ, Handelman G, Biddle L, Fielding RA, Meydani SN et al. Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults. Am J Physiol 1993; 264:R992-8.
29. 2+ channel blokers: multiple sites of action. Nippon Yakurigaku Zasshi 1992; 100:239-17.
30. Wauquier A, Ashton D, Marrannes R. The effects of flunarizine in experimental models related to the pathogenesis of migraine. Cephalalgia 1985; 5:119-23.
31. Akerman S, Williamson DJ, Kaube H, Goadsby PJ. The effect of anti-migraine compounds on nitric oxide-induced dilation of durai meningeal vessels. Eur J Pharmacol 2002; 452:223-8.
32. Hladovec J, De Clerck F. Protection by flunarizine against endothelial cell injury in vivo. Angiology 1981; 32:448-62.
33. Iqbal A, Vanhoutte PM. Flunarizine inhibits endothelium-dependent hypoxic facilitation in canine coronary arteries through an action on vascular smooth muscle. Br J Pharmacol 1988; 95:789-94.
34. Goncalves T, Carvalho AP, Oliveira CR. Antioxidant effect of calcium antagonists on microsomal membranes isolated from different brain areas. Eur J Pharmacol 1991; 204:315-22.
35. Aruoma OI, Smith C, Cecchini R, Evans PJ, Halliwell B. Free radical scavenging and inhibition of lipid peroxidation by beta-blokers and by agents that interfere with calcium metabolism. A physiologically-significant process? Biochem Pharmacol 1991; 42:735-13.