In vitro drug release studies from the polymeric hydrogels based on HEA and HPMA using 4-{(E)-[(3Z)-3-(4-(acryloyloxy)benzylidene)-2-hexylidene]methyl} phenyl acrylate as a crosslinker

Biomaterials

Volumn 26, Issue 10, 2005, Pages 1185-1193

  Arun, A ^a   Reddy, B S R ^a  

^a CENTRAL LEATHER RESEARCH INSTITUTE   (India)

Author keywords

Copolymer; Drug release; Hydrogel; Monomer

Indexed keywords

ABSORPTION; BIOSYNTHESIS; CHARACTERIZATION; CROSSLINKING; DRUG PRODUCTS; MONOMERS; PH EFFECTS; ULTRAVIOLET SPECTROMETERS;

CROSSLINKING AGENTS; CROSSLINKING DENSITY; POLYMERIC HYDROGELS;

HYDROGELS;

2',4 DICHLORO 5' FLUORO 1 ENE 2 (4 HYDROXYPHENYL)PHENONE; 4 [[3 (4 ACRYLOYLOXYBENZYLIDENE) 2 HEXYLIDENE]METHYL]PHENYLACRYLATE; ACRYLIC ACID 2 HYDROXYETHYL ESTER; ACRYLIC ACID DERIVATIVE; CHLORIDE; CYCLOHEXANONE DERIVATIVE; KETONE DERIVATIVE; METHACRYLIC ACID 2 HYDROXYPROPYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CROSS LINKING; DRUG MONITORING; DRUG RELEASE; DRUG SYNTHESIS; HYDROGEL; IN VITRO STUDY; INFRARED SPECTROSCOPY; MICROSCOPY; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCANNING ELECTRON MICROSCOPY; SPECTROMETER;

BIOCOMPATIBLE MATERIALS; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ETHYLENE GLYCOLS; HYDROCARBONS, HALOGENATED; HYDROGELS; HYDROGEN-ION CONCENTRATION; MATERIALS TESTING; METHACRYLATES; PARTICLE SIZE; POLYMERS; SURFACE PROPERTIES;

EID: 4644324015     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2004.04.023     Document Type: Article

References (17)

1. Arun A., Reddy B.S.R., Rajkumar M. Polymeric drug for antimicrobial activity studies. synthesis, characterization J Bio Active Compat Polym. 18:2003;219
2. Duncan A.C., Boughner D., Campbell G., Wan W.K. Preparation and characterization of a poly(2-hydroxyethyl methacrylate) biomedical hydrogel. Eur Polym J. 37(9):2001;1821
3. Katime I., Novoa R., Zuluaga F. Swelling kinetics and release studies of theophylline and aminophylline from acrylic acid/n-alkyl methacrylate hydrogels. Eur Polym J. 37(7):2001;1465
4. Brazel C.S., Peppas N.A. Mechanisms of solute and drug transport in relaxing, swellable, hydrophilic glassy polymers. Polymer. 40(12):1999;3383
5. Chiu H.C., Wu A.T., Lin Y.F. Synthesis and characterization of acrylic acid containing dextrane release. Polymer. 42:2001;1471
6. Kidchob T., Kimura S., Imanishi Y. Degradation and release profile of microcapsules made of poly[L-lactic acid-co-L-lysin(Z)]. J Controll Rel. 54:1998;283
7. Pradas M.M., Ribelles J.L.G., Aroca A.S., Ferrer G.G., Anton J.S., Pissis P. Porous poly(2-hydroxyethyl acrylate). Polymer. 42:2001;4667
8. Hill D.J.T., Moss N.G., Pomery P.J., Whittaker A.K. Copolymer hydrogels of 2-hydroxyethyl methacrylate with n-butyl methacrylate and cyclohexyl methacrylate. synthesis, characterization and uptake of water Polymer. 41:2000;1287
9. Okay O., Gurun C. Synthesis and formation mechanism of porous 2-hydroxy ethyl methacrylate-ethylene glycol dimethacrylate copolymer beads. J Appl Polym Sci. 46:1992;401
10. Schraufstattel E., Bernt H. Antimicrobial action of curcumin and related compound. Nature. 164:1949;456
11. Arun A., Reddy B.S.R. Influence of the comonomers (styrene and methyl acrylate) on the rate of photocrosslinking of 4-{[-3-(4-hydroxybenzylidene)-2 oxocyclohexylidene]methyl}phenyl acrylate. J Appl Polym Sci. 92(4):2004;2494
12. Juni K., Ogata J., Nakano M., Ichihara T., Mori K., Akagi M. Preparation and evaluation invitro and invivo of poly lactic acid microspheres containing doxorubicin. Chem Pharm Bull. 33:1985;313
13. Scranton A.B., Mikos A.G., Scranton L.C., Peppas N.A. The physical mechanism for the production of hydrophilic polymer microparticles from aqueous suspension. J Appl Polym Sci. 40:1990;997
14. Langer R, Siegel R, Brown L, Leong L, Kost J, Edelman E. In: Tirrel DA, Donaruma LG, Turek AB, editors, Drugs and carriers for biologically active materials. New York: Academy of Sciences; 1984. p. 1.
15. Gallardo A., Parejio C., Roman J.S. NSAID bound to methacrylic carriers. microstructural characterization and invitro release analysis J Controll Rel. 71:2001;127
16. Davaran S., Hanace J., Khosravi A. Release of 5-amino-salicylic acid from acrylic type polymeric prodrugs designed for colon-specific drug delivary. J Controll Rel. 58:1999;279
17. Peppas NA, Lustig Charles SR. In: Tirrel DA, Donaruma LG, Turek AB, editors, Drugs and carriers for biologically active materials. New York: Academy of Sciences; 1984. p. 26.