Infectious complications and outcomes after allogeneic hematopoietic stem cell transplantation in Korea

Bone Marrow Transplantation

Volumn 34, Issue 6, 2004, Pages 497-504

  Yoo, J H ^a,b   Lee, D G ^a   Choi, S M ^a   Choi, J H ^a   Park, Y H ^a   Kim, Y J ^a   Kim, H J ^a   Lee, S ^a   Kim, D W ^a   Lee, J W ^a   Min, W S ^a   Shin, W S ^a   Kim, C C ^a  

^a The Catholic University of Korea   (South Korea)

^b Holy Family Hospital   (South Korea)

Author keywords

Fever; HSCT; Infection; Korea

Indexed keywords

ACICLOVIR; BUSULFAN; CIPROFLOXACIN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTARABINE; ETHAMBUTOL; FLUCONAZOLE; GANCICLOVIR; ISONIAZID; MELPHALAN; METHOTREXATE; PYRAZINAMIDE; RIFAMPICIN; ROXITHROMYCIN; THIOTEPA;

ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; AUTOPSY; BACTERIAL INFECTION; CAUSE OF DEATH; CONFIDENCE INTERVAL; CYTOMEGALOVIRUS INFECTION; FEMALE; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HUMAN; INCIDENCE; INFECTION COMPLICATION; INFECTION SENSITIVITY; KOREA; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; MORTALITY; MOULD; MYCOSIS; PNEUMOCYSTIS PNEUMONIA; PRIORITY JOURNAL; RECIPIENT; RETROSPECTIVE STUDY; REVIEW; SIBLING; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; TUBERCULOSIS; VARICELLA ZOSTER VIRUS; VIRUS INFECTION; YEAST;

ADOLESCENT; ADULT; BACTERIAL INFECTIONS; FEMALE; HUMANS; INFECTION; KOREA; LEUKEMIA; LYMPHOMA; MALE; MIDDLE AGED; MYCOSES; MYELODYSPLASTIC SYNDROMES; RETROSPECTIVE STUDIES; STEM CELL TRANSPLANTATION; SURVIVAL ANALYSIS; TREATMENT OUTCOME; VIRUS DISEASES;

EID: 4644312366     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1704636     Document Type: Review

References (56)

1. Einsele H, Bertz H, Beyer J et al. Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies. Ann Hematol 2003; 82: s175-s185.
2. Ninin E, Milpied N, Moreau P et al. Longitudinal study of bacterial, viral and fungal infections in adult recipients of bone marrow transplants. Clin Infect Dis 2001; 33: 41-47.
3. Salutari P, Sica S, Bernardini A et al. Incidence of sepsis after peripheral blood progenitor cells transplant: analysis of 66 consecutive onco-hematological patients. Leak Lymphoma 1998; 30: 193-197.
4. Dykewicz CA. Summary of the guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. Clin Infect Dis 2001; 33: 139-144.
5. Weaver CH, Schwaftzberg LS, Hainsworth J et al. Treatment-related mortality in 1,000 consecutive patients receiving high-dose chemotherapy and peripheral blood progenitor cell transplantation in community cancer centers. Bone Marrow Transplant 1997; 19: 671-678.
6. Kolbe K, Domkin D, Derigs HG et al. Infectious complications during neutropenia subsequent to peripheral blood stem cell transplantation. Bone Marrow Transplant 1997; 19: 143-147.
7. Leather HL, Pharm B, Wingard JR. Infections following hematopoietic stem cell transplantation. Infect Dis Clin NA 2001; 15: 483-520.
8. Rubin RH. Infection in transplantation. Infect Dis Clin NA 1995; 9: 823-1043.
9. Kim DJ, Kim CC, Kim BK et al. Allogeneic bone marrow transplantation in Korea: 1983-1992. Bone Marrow Transplant 1994; 13: 717-719.
10. Choi JY, Shin WS, Yoo JH et al. Changing trend of infection after allogeneic bone marrow transplantation - comparison between 1983-1988 and 1989-1992. Kor J Antimicrob Chemother 1993; 11: 132-139 (in Korean).
11. Shin WS, Choi JH, Yoo JH et al. Infectious complications after bone marrow transplantation: experience of Catholic hematopoietic stem cell transplantation center from 1993 to 1996. Kor J Hematopoietic Stem Cell Transplant 1998; 3: 87-98 (in Korean).
12. Hughes WT, Armstrong D, Bodey GP et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Inject Dis 2002; 34: 730-751.
13. Ascioglu S, Rex JH, de Pauw B et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis 2002; 34: 7-14.
14. Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Cin Infect Dis 2002; 34: 1094-1097.
15. Thomas ED, Storb R, Clift RA et al. Bone marrow transplantation (second of two parts). N Engl J Med 1975; 292: 895-902.
16. Sullivan KM, Shulman HM, Storb R et al. Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression. Blood 1981; 57: 267-276.
17. Engels EA, Ellis CA, Supran SE et al. Early infection in bone marrow transplantation: quantitative study of clinical factors that affect risk. Clin Infect Dis 1999; 28: 256-266.
18. Akiyama H, Kurosu T, Sakashita C et al. Adenovirus is a key pathogen in hemorrhagic cystitis associated with bone marrow transplantation. Clin Infect Dis 2001; 32: 1325-1330.
19. Bedi A, Miller CB, Hanson JL et al. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol 1995; 13: 1103-1109.
20. Azzi A, Cesaro S, Laszlo D et al. Human polyomavirus BK (BKV) load and haemorrhagic cystitis in bone marrow transplantation patients. J Clin Virol 1999; 14: 79-86.
21. Baddley JW, Stroud TP, Salzman D et al. Invasive mold infections in allogeneic bone marrow transplant recipients. Clin Infect Dis 2001; 32: 1319-1324.
22. Wald A, Leisenring W, van Burik JA, Bowden RA. Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation. J Infect Dis 1997; 175: 1459-1466.
23. Winston DJ, Maziarz RT, Chandrasekar PH et al. Intravenous and oral itraconazole versus intravenous and oral fluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-cell transplant recipients. Ann Intern Med 2003; 138: 705-713.
24. Marr KA, Seidel K, Slavin MA et al. Prolonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial. Blood 2000; 96: 2055-2061.
25. Comely OA, Ullmann AJ, Karthaus M. Evidence-based assessment of primary antifungal prophylaxis in patients with hematologic malignancies. Blood 2003; 101: 3365-3372.
26. Wingard JR. Antifungal chemoprophylaxis after blood and marrow transplantation. Clin Infect Dis 2002; 34: 1386-1390.
27. van Delden C, Lew DP, Chapuis B et al. Antifungal prophylaxis in severely neutropenic patients: how much fluconazole is necessary? Clin Microbiol Infect 1995; 1: 24-30.
28. Philpott-Howard JN, Wade JJ, Mufti GJ et al. Randomized comparison of oral fluconazole vs oral polyene for the prevention of fungal infection in patients at risk of neutropenia. Multicentre Study Group. J Antimicrob Chemother 1993; 31: 973-984.
29. Kanda Y, Yamamoto R, Chizuka A et al. Prophylactic action of oral fluconazole against fungal infection in neutropenic patients: a meta-analysis of 16 randomized, controlled trials. Cancer 2000; 89: 1611-1625.
30. Safdar A, van Rhee F, Henslee-Downey JP et al. Candida glabrata and Candida krusei fungemia after high-risk allogeneic marrow transplantation: no adverse effect of low-dose fluconazole prophylaxis on incidence and outcome. Bone Marrow Transplant 2001; 28: 873-887.
31. Locksley RM, Flournoy N, Sullivan KM, Meyers JD. Infection with varicella zoster virus after marrow transplantation. J Infect Dis 1985; 152: 1172-1181.
32. Koc Y, Miller KB, Schenkein DP et al. Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. Biol Blood Marrow Transplant 2000; 6: 44-49.
33. Yoo JH, Kim YR, Shin WS et al. Five cases of cytomegalovirus infection detected by in situ hybridization and anti-genemia assay. Korean J Med Sci 1994; 9: 507-512.
34. Boeckh M, Leisenring W, Riddell SR et al. Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity. Blood 2003; 101: 407-414.
35. Nguyen Q, Champlin R, Giralt S et al. Late cytomegalovirus pneumonia in adult allogeneic blood and marrow transplant recipients. Clin Infect Dis 1999; 28: 618-623.
36. Goodrich JM, Mori M, Gleaves CA et al. Early treatment with ganciclovir to prevent cytomegalovirus disease after allogeneic bone marrow transplantation. N Engl J Med 1991; 325: 1601-1607.
37. Einsele H, Ehninger G, Hebart H et al. Polymerase chain reaction monitoring reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation. Blood 1995; 86: 2815-2820.
38. Ljungman P, Aschan J, Lewensohn-Fuchs I et al. Results of different strategies for reducing cytomegalovirus-associated mortality in allogeneic stem cell transplant recipients. Transplantation 1998; 66: 1330-1334.
39. Zaia JA, Gallez-Hawkins GM, Tegtmeier BR et al. Late cytomegalovirus disease in marrow transplantation is predicted by virus load in plasma. J Infect Dis 1997; 176: 782-785.
40. Roy V, Weisdorf D. Mycobacterial infections following bone marrow transplantation: a 20 year retrospective review. Bone Marrow Transplant 1997; 19: 467-470.
41. Aljurf M, Gyger M, Alrajhi A et al. Mycobacterium tuberculosis infection in allogeneic bone marrow transplantation patients. Bone Marrow Transplant 1999; 24: 551-554.
42. de la Camara R, Martino R, Granados E et al. Tuberculosis after hematopoietic stem cell transplantation: incidence, clinical characteristics and outcome. Spanish group on infectious complications in hematopoietic transplantation. Bone Marrow Transplant 2000; 26: 291-298.
43. Ku SC, Tang JL, Hsueh PR et al. Pulmonary tuberculosis in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2001; 27: 1293-1297.
44. Budak-Alpdogan T, Tangun Y, Kalayoglu-Besisik S et al. The frequency of tuberculosis in adult allogeneic stem cell transplant recipients in Turkey. Biol Blood Marrow Transplant 2000; 6: 370-374.
45. Hong YP, Kim SJ, Lew WJ et al. The seventh nationwide tuberculosis prevalence survey in Korea, 1995. J Tuberc Lung Dis 1998; 2: 27-36.
46. Lee J, Lee MH, Kim WS et al. Tuberculosis in hematopoietic stem cell transplant recipients in Korea. Int J Hematol 2004; 79: 185-188.
47. Saito T, Seo S, Kanda Y et al. Early onset Pneumocystis carinii pneumonia after allogeneic peripheral blood stem cell transplantation. Am J Hematol 2001; 67: 206-209.
48. Tuan IZ, Dennision D, Weisdorf DJ. Pneumocystis carinii pneumonitis following bone marrow transplantation. Bone Marrow Transplant 1992; 10: 267-272.
49. Lyytikainen O, Ruutu T, Volin L et al. Late onset Pneumocystis carinii pneumonia following allogeneic bone marrow transplantation. Bone Marrow Transplant 1996; 17: 1057-1059.
50. Machado CM, Goncalves FB, Pannuti CS et al. Measles in bone marrow transplant recipients during an outbreak in Sao Paulo, Brazil. Blood 2002; 99: 83-87.
51. Na BK, Shin JM, Lee JY et al. Genetic and antigenic characterization of measles viruses that circulated in Korea during the 2000-2001 epidemic. J Med Virol 2003; 70: 649-654.
52. Weisdorf DJ, Anasetti C, Antin JH et al. Allogeneic bone marrow transplantation for chronic myelogenous leukemia: comparative analysis of unrelated vs matched sibling donor transplantation. Blood 2002; 99: 1971-1977.
53. Marks DI, Cullis JO, Ward KN et al. Allogeneic bone marrow transplantation for chronic myeloid leukemia using sibling and volunteer unrelated donors. A comparison of complications in the first 2 years. Ann Intern Med 1993; 119: 207-214.
54. Takenaka K, Gondo H, Tanimoto K et al. Increased incidence of cytomegalovirus (CMV) infection and CMV associated disease after allogeneic bone marrow transplantation from unrelated donors. Bone Marrow Transplant 1997; 19: 241-248.
55. de la Camara R, Fernandez-Ranada JM. Increased incidence of CMV infection after allogeneic bone marrow transplantation from unrelated donors but doubts about an increase in CMV-associated disease. Bone Marrow Transplant 1997; 20: 181.
56. Loberia Jr F. Reports on state of the art in blood and marrow transplantation - Part I of the IBMTR/ABMTR summary slides with guide. IBMTR/ABMTR Newsletter 2003; 10: 7-10. http://instruct.mcw.edu/IBMTR/BWebServer/summarysldset/summset.htm.