Evaluation of the cumulative irritation potential of tretinoin: Review of 2 clinical studies

Cosmetic Dermatology

Volumn 15, Issue 7, 2002, Pages 33-36

  Nyirady, Judit ^a   Grossman, Rachel ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID;

ADULT; ARTICLE; CLINICAL TRIAL; CREAM; DRUG DOSAGE FORM; DRUG EFFICACY; DRUG SAFETY; HUMAN; HYPERPIGMENTATION; PRESCRIPTION; SKIN IRRITATION; WRINKLE;

EID: 4644306780     PISSN: 10413766     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Kligman AM, Grove GL, Hirose R, Leyden JJ. Topical tretinoin for photoaged skin. J Am Acad Dermatol. 1986;15:836-859.
2. Weiss JS, Ellis CN, Headington JT, et al. Topical tretinoin improves photoaged skin: a double-blind vehicle-controlled study. JAMA. 1988;259:527-532.
3. Leyden JJ, Grove GL, Grove MJ, et al. Treatment of photodamaged facial skin with topical tretinoin. J Am Acad Dermatol. 1989;21:638-644.
4. Lever L, Kumar P, Marks R. Topical retinoic acid for treatment of solar damage. Br J Dermatol. 1990;122:91-98.
5. Weinstein GD, Nigra TP, Pochi PE, et al. Topical tretinoin for treatment of photodamaged skin: a multicenter study. Arch Dermatol. 1991;127:659-665.
6. Olsen EA, Katz HI, Levine N, et al. Tretinoin emollient cream: a new therapy for photodamaged skin. J Am Acad Dermatol. 1992;26:215-224.
7. Data on file. Ortho Dermatological, Skillman, NJ.
8. Griffiths CE, Kang S, Ellis CN, et al. Two concentrations of topical tretinoin (retinoic acid) cause similar improvement in photoaging but different degrees of irritation: a double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams. Arch Dermatol. 1995;131:1037-1044.
9. Quigley JW, Bucks DA. Reduced skin irritation with tretinoin containing polyolprepolymer-2, a new topical tretinoin delivery system: a summary of preclinical and clinical investigations. J Am Acad Dermatol. 1998;38:S5-S10.
10. Mills OH, Berger RS. Irritation potential of a new topical tretinoin formulation and a commercially-available tretinoin formulation as measured by patch testing in human subjects. J Am Acad Dermatol. 1998;38:S11-S16.
11. Nyirady J, Bergfeld W, Ellis C, et al. Tretinoin cream 0.02% for the treatment of photodamaged facial skin: a review of 2 double-blind clinical studies. Cutis. 2001;68:135-142.