Health effects of dental amalgam exposure: A retrospective cohort study

International Journal of Epidemiology

Volumn 33, Issue 4, 2004, Pages 894-902

  Bates, Michael N ^a,b   Fawcett, Jackie ^a,c   Garrett, Nick ^a,d   Cutress, Terry ^c   Kjellstrom, Tord ^e,f  

^a INSTITUTE OF ENVIRONMENTAL SCIENCE AND RESEARCH   (New Zealand)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d AUCKLAND UNIVERSITY OF TECHNOLOGY   (New Zealand)

^e UNIVERSITY OF AUCKLAND   (New Zealand)

^f The Australian National University   (Australia)

Author keywords

Chronic fatigue syndrome; Cohort studies; Dental amalgam; Kidney diseases; Mercury; Multiple sclerosis; New Zealand

Indexed keywords

DENTAL ALLOY;

HEALTH IMPACT;

ADOLESCENT; ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CHRONIC FATIGUE SYNDROME; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA ANALYSIS; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HUMAN; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MILITARY SERVICE; MORBIDITY; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NEW ZEALAND; OCCUPATIONAL DISEASE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; PARKINSON DISEASE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; STATISTICAL MODEL; TOOTH FILLING;

ADOLESCENT; ADULT; AGED; ALZHEIMER DISEASE; DENTAL AMALGAM; FATIGUE SYNDROME, CHRONIC; FEMALE; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PARKINSON DISEASE;

EID: 4644305487     PISSN: 03005771     EISSN: None     Source Type: Journal    
DOI: 10.1093/ije/dyh164     Document Type: Article

References (33)

1. Clarkson TW. The toxicology of mercury. Crit Rev Clin Lab Sci 1997; 34:369-403.
2. Satoh H. Occupational and environmental toxicology of mercury and its compounds. Ind Health 2000;38:153-64.
3. Abraham JE, Svare CW, Frank CW. The effect of dental amalgam restorations on blood mercury levels. J Dent Res 1984;63:71-73.
4. Snapp KR, Boyer DB, Peterson LC, Svare CW. The contributions of dental amalgam to mercury in blood. J Dent Res 1989;68:780-85.
5. Vimy MJ, Lorscheider FL. Dental amalgam mercury daily dose estimated from intra-oral vapor measurements: a predictor of mercury accumulations in human tissues. J Trace Elem Exp Med 1990;3:111-23.
6. Weiner JA, Nylander M, Berglund F. Does mercury from amalgam restorations constitute a health hazard? Sci Total Environ 1990;99:1-22.
7. DHHS (Department of Health and Human Services). Public Health Service. Dental amalgam: a scientific review and recommended Public Health Service strategy for research, education and regulation. Final report of the Subcommittee on Risk management of the Committee to Co-ordinate Environmental Health and Related Programs. 1993.
8. Cutress TW. Dental amalgam and human health, current situation - a New Zealand review. In: Mjor IA, Pakomov GN (eds). Dental Amalgam and Alternative Direct Restorative Materials. Geneva: World Health Organization, 1997, pp. 63-71.
9. Craelius W. Comparative epidemiology of multiple sclerosis and dental caries. J Epidemiol Community Health 1978;32:155-65.
10. Saxe SR, Wekstein MW, Kryscio RJ et al. Alzheimer's disease, dental amalgam and mercury. J Am Dent Assoc 1999;130:191-99.
11. Seidler A, Hellenbrand W, Robra B-P et al. Possible environmental, occupational, and other etiologic factors for Parkinson's disease: a case-control study in Germany. Neurology 1996;46:1275-84.
12. Stejskal VD, Danersund A, Lindvall A et al. Metal-specific lymphocytes: biomarkers of sensitivity in man. Neuroendocrinol Lett 1999;20:289-98.
13. Fawcett J, Garrett N, Bates MN. Follow-up methods for retrospective cohort studies in New Zealand. A N Z J Public Health 2002;26:256-61.
14. Cox DR. Regression Models and Life-Tables. J R Statist Soc B 1972;34:187-220.
15. Factor-Litvak P, Hasselgren G, Jacobs D et al. Mercury derived from dental amalgams and neuropsychologic function. Environ Health Perspect 2003;111:719-23.
16. Ahlqwist M, Bengtsson C, Lapidus L. Number of amalgam fillings in relation to cardiovascular disease, diabetes, cancer and early death in Swedish women. Community Dent Oral Epidemiol 1993;21:40-44.
17. Ahlqwist M, Bengtsson C, Lapidus L, Bergdahl IA, Schütz A. Serum mercury concentration in relation to survival, symptoms, and diseases: results from the prospective population study of women in Gothenburg, Sweden. Acta Odontol Scand 1999;57:168-74.
18. Ahlqwist M, Bengtsson C, Furunes B, Hollender L, Lapidus L. Number of amalgam fillings in relation to subjectively experienced symptoms in a study of Swedish women. Community Dent Oral Epidemiol 1988; 16:227-31.
19. Malt UF, Nerdrum P, Oppedal B, Gundersen R, Holte M, Löne J. Physical and mental problems attributed to dental amalgam fillings: a descriptive study of 99 self-referred patients compared with 272 controls. Psychosomatic Med 1997;59:32-41.
20. Bratel J, Haraldson T, Meding B, Yontchev E, Ohman SC, Ottosson JO. Potential side effects of dental amalgam restorations: (1) An oral and medical investigation. Eur J Oral Sci 1997;105:234-43.
21. Bratel J, Haraldson T, Ottoson J-O. Potential side effects of dental amalgam restorations: (2) No relation between mercury levels in the body and mental disorders. Eur J Oral Sci 1997;105:244-50.
22. Melchart D, Wühr E, Weidenhammer W, Kremers L. A multi-center survey of amalgam fillings and subjective complaints in non-selected patients in the dental practice. Eur J Oral Sci 1998;106:770-77.
23. Gauss C, Gottwald B, Traencker I et al. Relation between mercury concentrations in saliva, blood, and urine in subjects with amalgam restorations. Clin Oral Investig 2000;4:206-11.
24. Bailer J, Rist F, Rudolf A et al. Adverse health effects related to mercury exposure from dental amalgam fillings: toxicological or psychological causes? Psychol Med 2001;31:255-63.
25. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology 1990;1:43-46.
26. Ingalls TH. Epidemiology, etiology, and prevention of multiple sclerosis. Hypothesis and fact. Am J Forensic Med Pathol 1983;4:55-60.
27. Kurtzke JF. Geography in multiple sclerosis. J Neurol 1977;215:1-26.
28. McMichael AJ, Hall AJ. Multiple sclerosis and ultraviolet radiation: time to shed more light. Neuroepidemiology 2001;20:165-67.
29. Van der Mei IAF, Ponsonby AL, Blizzard L, Dwyer T. Regional variation in multiple sclerosis prevalence in Australia and its association with ambient ultraviolet radiation. Neuroepidemiology 2001;20:168-74.
30. Bangsi D, Ghadirian P, Dudic S et al. Dental amalgam and multiple sclerosis: a case-control study in Montreal, Canada. Int J Epidemiol 1998;27:667-71.
31. McGrother CW, Dugmore C, Phillips MJ, Raymond NT, Garrick P, Baird WO. Multiple sclerosis, dental caries and fillings: a case-control study. Br Dent J 1999;187:261-64.
32. Casetta I, Ivernizzi M, Granieri E. Multiple sclerosis and dental amalgam: case-control study in Ferrara, Italy. Neuroepidemiology 2001;20:134-37.
33. Peduzzi P, Concato J, Feinstein AR, Holford TR. Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol 1995;48:1503-10.