A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental mouse model

Infection and Immunity

Volumn 72, Issue 10, 2004, Pages 6157-6159

  Lee, Young Rae ^a   Park, Kwang Hyun ^a   Lin, Zhao Zhen ^a   Kho, Young Jong ^a   Park, Jin Woo ^a   Rho, Hye Won ^a   Koo, Bon Sun ^a   Kim, Hyung Rho ^a   Song, Eun Kyung ^a   Yu, Hong Nu ^a   Han, Myung Kwan ^a   Lee, Seung Ok ^a   Jhee, Eun Chung ^b   Kim, Jong Suk ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALMODULIN; CYTOLYSIN; TETRACYCLINE; TRIFLUOPERAZINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; GRAM NEGATIVE INFECTION; LETHALITY; LUNG EDEMA; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; VIBRIO VULNIFICUS;

ALBUMINS; ANIMALS; CALCIUM; CALMODULIN; CAPILLARY PERMEABILITY; CELL LINE; CYTOTOXINS; ENDOTHELIAL CELLS; MICE; MODELS, ANIMAL; PROTEIN TRANSPORT; TRIFLUOPERAZINE; VIBRIO VULNIFICUS;

EID: 4644300375     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.10.6157-6159.2004     Document Type: Article

References (19)

1. Blake, P. A., M. H. Merson, R. E. Weaver, D. G. Hollis, and P. C. Heublein. 1979. Disease caused by a marine Vibrio. Clinical characteristics and epidemiology. N. Engl. J. Med. 300:1-5.
2. Chiang, S. R., and Y. C. Chuang. 2003. Vibrio vulnificus infection: clinical manifestations, pathogenesis, and antimicrobial therapy. J. Microbiol. Immunol. Infect. 36:81-88.
3. Fan, J.-J., C.-P. Shao, Y.-C. Ho, C.-K. Yu, and L.-I. Hor. 2001. Isolation and characterization of a Vibrio vulnificus mutant deficient in both extracellular metalloprotease and cytolysin. Infect. Immun. 69:5943-5948.
4. Gray, L. D., and A. S. Kreger. 1987. Mouse skin damage caused by cytolysin from Vibrio vulnificus and by V. vulnificus infection. J. Infect. Dis. 155:236-241.
5. Gray, L. D., and A. S. Kreger. 1989. Detection of anti-Vibrio vulnificus cytolysin antibodies in sera from mice and a human surviving V. vulnificus disease. Infect. Immun. 51:964-965.
6. Gray, L. D., and A. S. Kreger. 1989. Detection of Vibrio vulnificus cytolysin in V. vulnificus-infected mice. Toxicon 27:439-464.
7. Hollis, D. G., R. E. Weaver, C. N. Baker, and C. Thornsberry. 1976. Halophilic Vibrio species isolated from blood cultures. J. Clin. Microbiol. 3:425-431.
8. Kim, B. S., and J. S. Kim. 2002. Vibrio vulnificus cytolysin induces hyperadhesiveness of pulmonary endothelial cells for neutrophils through endothelial P-selectin: a mechanism for pulmonary damage by Vibrio vulnificus cytolysin. Exp. Mol. Med. 34:308-312.
9. Linkous, D. A., and J. D. Oliver. 1999. Pathogenesis of Vibrio vulnificus. FEMS Microbiol. Lett. 174:207-214.
10. McPherson, V. L., J. A. Watts, L. M. Simpson, and J. D. Oliver. 1991. Physiological effects of the lipopolysaccharide of Vibrio vulnificus on mice and rats. Microbios 67:141-149.
11. Osborn, M., and K. Weber. 1980. Damage of cellular functions by trifluoperazine, a calmodulin-specific drug. Exp. Cell Res. 130:484-488.
12. Park, J.-W., S.-N. Ma, E.-S. Song, C.-H. Song, M.-R. Chae, B.-H. Park, H.-W. Rho, S.-D. Park, and H.-R. Kim. 1996. Pulmonary damage by Vibrio vulnificus cytolysin. Infect. Immun. 64:2873-2876.
13. Park, S. D., H. S. Shon, and N. J. Joh. 1991. Vibrio vulnificus septicemia in Korea: clinical and epidemiologic findings in seventy patients. J. Am. Acad. Dermatol. 24:397-403.
14. Rho, H. W., M. J. Choi, J. N. Lee, J. W. Park, J. S. Kim, B. H. Park, H. S. Sohn, and H. R. Kim. 2002. Cytotoxic mechanism of Vibrio vulnificus cytolysin in CPAE cells. Life Sci. 70:1923-1934.
15. Shao, C.-P., and L.-I. Hor. 2000. Metalloprotease is not essential for Vibrio vulnificus virulence in mice. Infect. Immun. 68:3569-3573.
16. Suttorp, N., T. Hessz, W. Seeger, A. Wilke, R. Koob, F. Lutz, and D. Drenckhahn. 1988, Bacterial exotoxins and endothelial permeability for water and albumin in vitro. Am. J. Physiol, 255:C368-C376.
17. 2 and lysophospholipase produced by Vibrio vulnificus. Infect. Immun. 45:458-463.
18. Weiss, B., and R. M. Levin. 1978. Mechanism for selectively inhibiting the activation of cyclic nucleotide phosphodiesterase and adenylate cyclase by antipsychotic agents. Adv. Cyclic Nucleotide Res. 9:285-303.
19. Wright, A. C., and J. G. Morris, Jr. 1991. The extracellular cytolysin of Vibrio vulnificus: inactivation and relationship to virulence in mice. Infect. Immun. 59:192-197.