Synthesis and anti-influenza virus activity of ethyl 6-bromo-5- hydroxyindole-3-carboxylate derivatives

Chinese Chemical Letters

Volumn 15, Issue 9, 2004, Pages 1039-1042

  Zhao, Yan Fang ^a   Dong, Jin Hua ^a   Gong, Ping ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti influenza virus activity; Ethyl 6 bromo 5 hydroxyindole 3 carboxylate derivatives; Synthesis

Indexed keywords

ANTIVIRUS AGENT; CARBOXYLIC ACID DERIVATIVE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; INFLUENZA VIRUS; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

EID: 4644291274     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. I. D. Gust, A. W. Hampson, D. Lavanchy, Rev. Med. Virol., 2001, 11, 59.
2. R. G. Glushkov, Drugs of Fut., 1992, 17 (12), 1079.
3. This article has been recepted by Chin.Chem.Lett. to be published.
4. S. A. Clickman, A. C. Cope, J. Am. Chem. Soc., 1946, 67, 1017.
5. S. A. Monti, J. Org. Chem., 1966, 31, 2669.
6. A. N. Grinev, G. N. Pershin, WO 9008135, 1990.
7. 1H NMR: δppm: 1.06 (m, 2 H), 1.09 (t, 3 H, J=7.1 Hz), 1.23 (m, 2 H), 3.12 (m, 1 H), 3.99 (q, 2 H, J=7.1 Hz), 4.67 (s, 2 H), 5.78 (s, 2 H), 7.13 (m, 2 H), 7.33 (m, 2 H), 7.42 (s, 1 H), 7.59 (s, 1 H), 7.92 (s, 1 H), 8.83 (s, 1 H), 9.35 (s, 1 H), 14.61 (brs, 1 H).