Stereoselective synthesis of the γ-lactam hydrolysate of the thiopeptide cyclothiazomycin

Organic Letters

Volumn 6, Issue 19, 2004, Pages 3401-3404

  Bagley, Mark C ^a   Xiong, Xin ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; CYCLOTHIAZOMYCIN;

ARTICLE; CHEMICAL REACTION; CHIRALITY; DRUG SYNTHESIS; PURIFICATION; RACEMIZATION; STEREOCHEMISTRY;

ANTI-BACTERIAL AGENTS; CATALYSIS; INDICATORS AND REAGENTS; LACTAMS; MOLECULAR STRUCTURE; PEPTIDES; PEPTIDES, CYCLIC; STEREOISOMERISM; THIAZOLES;

EID: 4644285613     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0485870     Document Type: Article

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25. We are grateful to Masahiro Aoki (Chugai Pharmaceutical Co., Ltd., Japan) and Prof. Haruo Seto (Institute of Applied Microbiology, The University of Tokyo, Japan) for further details.
26. f0.64 on silica, eluting with nBuOH-AcOH-water (3:1:1).
27. max (MeOH) 234 nm (ε 12 400), 314 nm (ε 17 000). See Supporting Information for more experimental details and spectroscopic data.
28. max (MeOH) 230 nm (ε 12 200), 321 nm (ε 14 400). See Supporting Information for more experimental details and spectroscopic data.