Analytical product study of germanium-containing medicine by different ICP-MS applications

Journal of Trace Elements in Medicine and Biology

Volumn 18, Issue 1, 2004, Pages 9-16

  Krystek, Petra ^a   Ritsema, Rob ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Beta carboxyethylgermanium sesquioxide; Ge 132; ICP MS; Inductively coupled plasma mass spectrometry; Organo germanium

Indexed keywords

CARBOXYETHYLGERMANIUM SESQUIOXIDE; GEC 2100; GERMANIUM; GERMANIUM LACTATE CITRATE; ISOTOPE; NIOBIUM; NIOBIUM 93; ORGANOGERMANIUM COMPOUND; RUBIDIUM; RUBIDIUM 85; SPIROGERMANIUM; STRONTIUM; STRONTIUM 88; UNCLASSIFIED DRUG; YTTRIUM; YTTRIUM 89; ZIRCONIUM; ZIRCONIUM 90;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CANCER; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DILUTION; DRUG DETERMINATION; DRUG TOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

EID: 4644280140     PISSN: 0946672X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtemb.2004.04.003     Document Type: Article

References (15)

1. Tao S-H, Bolger PM. Hazard assessment of germanium supplements. Regul Toxicol Pharmacol 1997;25:211-9.
2. Lück BE, Mann H, Melzer H, Dunemann L, Begerow J. Renal and other organ failure caused by germanium intoxication. Nephrol Dial Transplant 1999;14:2464-8.
3. Gerber GB, Leonard A. Mutagenicity, carcinogenicity and teratogenicity of germanium compounds. Mutat Res Rev Mutat Res 1997;387:141-6.
4. Lin CH, Chen TJ, Hsieh YL, Jiang SJ, Chen SS. Kinetics of germanium dioxide in rats. Toxicology 1999;132:147-53.
5. Krapf R, Schaffner T, Iten PX. Abuse of germanium associated with fatal lactic acidosis. Nephron 1992;62:351-6.
6. Schauss AG. Nephrotoxicity and neurotoxicity in humans from organogermanium compounds and germanium dioxide. Biol Trace Elem Res 1991;29:267-80.
7. Loren K. Life flow one, the solution for heart disease. 3rd ed., 1998. Published on the web, URL: http://www.karlloren.com.
8. Grüter UM, Kresimon J, Hirner AV. A new HG/LT-GC/ICP-MS multi-element speciation technique for real samples in different matrices. Fresenius J Anal Chem 2000;368:67-72.
9. Tseng CM, Amouroux D, Brindle ID, Donard OFX. Field cryofocussing hydride generation applied to the simultaneous multi-elemental determination of alkylmetal(loid) species in natural waters using ICP-MS detection. J Environ Monit 2000;2:603-12.
10. Riley CM, Monnot EA, Stobaugh JF, Slavik M. Determination of spirogermanium (2-aza-8-germanspiro [4.5]-decane-2-propanamine-8,8-diethyl-N,N- dimethyl dichloride) by fluorometric ion-pair extraction. Application to the uniformity of content of solutions for intravenous injection. J Pharmaceut Biomed Anal 1989;7:385-92.
11. Chen Q-C, Mou S-F, Yan Y, Ni Y-M. Separation and determination of inorganic germanium and beta-carboxyethylgermanium sesquioxide by high-performance ion-exclusion chromatography. J Chromatogr A 1997;789:403-12.
12. Zhang D-q, Ni Z-m. Separation and determination of trace inorganic germanium in beta-carboxethylgermanium sesquioxide by filtration chromatography and hydride generation-graphite furnace atomic absorption spectrometry. Analyt Chim Acta 1996;330:53-8.
13. Zomer, B. RIVM, 2001. Personal communication.
14. Giessmann U, Greb U. High resolution ICP-MS - a new concept for elemental mass spectrometry. Fresenius J Anal Chem 1994;350:186-93.
15. Moens L, Jakubowski N. Double-focusing mass spectrometers in ICPMS. Anal Chem 1998;70:A251-6.