Negative immunohistochemical staining of p53 protein does not always reflect wild-type p53 gene in cancer cells [1]

Journal of Gastroenterology

Volumn 39, Issue 8, 2004, Pages 801-803

  Horiuchi, Hideki ^a,b   Kawamata, Hitoshi ^a   Omotehara, Fumie ^a   Fujii, Shigehiko ^a   Fujimori, Takahiro ^a   Kuroda, Yoshikazu ^b  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

CANCER CELL; COLON CANCER; CONFORMATIONAL TRANSITION; DISEASE ASSOCIATION; DNA BINDING; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CODE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LETTER; MISSENSE MUTATION; MOUTH CARCINOMA; ONCOGENE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; ULCERATIVE COLITIS;

ADENOCARCINOMA; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; COLON; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LOSS OF HETEROZYGOSITY; MUTATION; MUTATION, MISSENSE; POINT MUTATION; PREDICTIVE VALUE OF TESTS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 4644270381     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00535-003-1378-2     Document Type: Letter

References (10)

1. Lane DP, Crawford LV. T antigen is bound to a host protein in SV40-transformed cells. Nature 1979;278:261-3.
2. Baker SJ, Fearon ER, Nigro JM, Hamilton SR, Preisinger AC, Jessup JM, et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 1989;244:217-21.
3. Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, et al. Mutations in the p53 gene occur in diverse human tumor types. Nature 1989;342:705-8.
4. Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997;387:296-9.
5. Whitesell L, Sutphin PD, Pulcini EJ, Martinez JD, Cook PH. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. Mol Cell Biol 1998;18:1517-24.
6. IARC TP53 Mutation database. http://www.iarc.fr/p53
7. Kressner U, Inganas M, Byding S, Blikstad I, Pahlman L, Glimelius B, et al. Prognostic value of p53 genetic changes in colorectal cancer. J Clin Oncol 1999;17:593-9.
8. Fujii S, Fujimori T, Chiba T. Usefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia. J Exp Clin Cancer Res 2003;22: 421-9.
9. Hoque MO, Kawamata H, Nakashiro K, Omotehara F, Hino S, Uchida D, et al. Dysfunction of the p53 tumor suppressor pathway in head and neck cancer. Int J Oncol 2002;21:119-26.
10. Shinagawa Y, Kawamata H, Omotehara F, Nakashiro K, Hoque MO, Furihata T, et al. Evaluation of the chemosensitivity of head and neck cancer cells based on the diverse function of mutated-p53. Int J Oncol 2003;22:383-9.