Lindera strychnifolia is protective against post-ischemic myocardial dysfunction through scavenging hydroxyl radicals and opening the mitochondrial KATP channels in isolated rat hearts

American Journal of Chinese Medicine

Volumn 32, Issue 4, 2004, Pages 587-598

  Wang, Ningyuan ^a   Minatoguchi, Shinya ^a   Arai, Masazumi ^a   Uno, Yoshihiro ^a   Hashimoto, Kazuaki ^a   Xue Hai, Chen ^a   Fukuda, Kazunori ^a   Akao, Seigo ^a   Takemura, Genzou ^a   Fujiwara, Hisayoshi ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cardiac function; Hydroxyl radicals; Lindera strychnifolia; Mitochondrial KATP channel; Myocardial dysfunction

Indexed keywords

5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE; CARBON DIOXIDE; GENTISIC ACID; HYDROXYL RADICAL; LACTATE DEHYDROGENASE; LACTIC ACID; LINDERA STRYCHNIFOLIA EXTRACT; OXYGEN; PLANT EXTRACT; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOSE RESPONSE; HEART DISEASE; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MITOCHONDRION; HEART MUSCLE ISCHEMIA; HEART PACING; HEART PERFUSION; HEART PROTECTION; ISOLATED HEART; JAPAN; KIDNEY DISEASE; LINDERA; MALE; NONHUMAN; PLANT ROOT; RAT; REPERFUSION INJURY; RHEUMATIC DISEASE; SCAVENGING SYSTEM;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENTISATES; HEART; HYDROXYL RADICAL; L-LACTATE DEHYDROGENASE; LINDERA; MALE; MEMBRANE PROTEINS; MYOCARDIAL ISCHEMIA; PLANT PREPARATIONS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FUNCTION, LEFT;

EID: 4644261163     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X04002223     Document Type: Article

References (10)

1. Bergmyer, H.U. Methods of Enzymatic Analysis. Academic Press Inc., New York, 1974, pp. 1446-1451.
2. Blaustein, A.S., L. Schine, W.W. Brooks, B.L. Fanburg and O.H.L. Bing. Influence of exogenously generated oxidant species on myocardial function. Am. J. Physiol. 250: H595-599, 1986.
3. Bolli, R. Oxygen-derived free radicals and postischemic myocardial dysfunction ("stunned myocardium"). J. Am. Coll. Cardiol. 12: 239-249, 1988.
4. Burton, K.P., J.M. McCord and G. Ghai. Myocardial alterations due to free radical generation. Am. J. Physiol. 246: H776-783, 1984.
5. Ferranti, R., M.M. da Silva and A.J. Kowaltowski. Mitochondrial ATP-sensitive K+ channel opening decreases reactive oxygen species generation. FEBS Lett. 536: 51-55, 2003.
6. Floyd, R.A., J.J. Watson and P.K. Wong. Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products. J. Biochem. Biophys. Methods 10: 221-235, 1984.
7. Grootvelt, M. and B. Halliwell. Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo: identification of hydroxylated derivatives of salicylate in human body fluid. Biochem. J. 237: 499-504, 1986.
8. Liu, Y., T. Sato, B. O'Rourke and E. Marban. Mitochondrial ATP-dependent potassium channels, novel effectors of cardioprotection? Circulation 97: 2463-2469, 1998.
9. Ozcan, C., M. Bienengraeber, P.P. Dzeja and A. Terzic. Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation. Am. J. Physiol. Heart Circ. Physiol. 282: H531-539, 2002.
10. Wang, Y., K. Hirai and M. Ashraf. Activation of mitochondrial ATP-sensitive K(+) channel for cardiac protection against ischemic injury is dependent on protein kinase C activity. Circ. Res. 85: 731-741, 1999.