In vitro and in vivo effects of an α3 neuronal nicotinic acetylcholine receptor antisense oligonucleotide

Molecular Brain Research

Volumn 129, Issue 1-2, 2004, Pages 67-79

  Adams, Monique R ^a   Nikkel, Arthur L ^a   Donnelly Roberts, Diana L ^a   Watt, Andrew T ^b   Johnston, Joseph F ^b   Cowsert, Lex M ^b   Butler, Mandeline ^b   Kroeger, Paul E ^a   Frost, Leigh ^a   Curzon, Peter ^a   Decker, Michael W ^a   Bitner, Robert Scott ^a  

^a ABBOTT LABORATORIES   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

Alpha3; Antisense; Epibatidine; Nicotine

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; EPIBATIDINE; ISIS 106567; MESSENGER RNA; NICOTINE; NICOTINIC RECEPTOR ALPHA3; PROTEIN C FOS; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HABENULA; HYPOTHERMIA; MALE; MICTURITION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PRIORITY JOURNAL; RAT; SEIZURE; THALAMUS;

ANIMALS; BEHAVIOR, ANIMAL; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CALCIUM; IN SITU HYBRIDIZATION; MALE; NEURONS; NICOTINIC AGONISTS; OLIGONUCLEOTIDES, ANTISENSE; PC12 CELLS; PROTEIN SUBUNITS; PROTO-ONCOGENE PROTEINS C-FOS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; RNA, MESSENGER;

MAMMALIA;

EID: 4644254846     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2004.06.019     Document Type: Article

References (35)

1. R.S. Bitner, A.L. Nikkel, P. Curzon, S.P. Arneric, A.W. Bannon, and M.W. Decker Role of the nucleus raphe magnus in antinociception produced by ABT-594: immediate early gene responses possibly linked to neuronal nicotinic acetylcholine receptors on serotonergic neurons J. Neurosci. 18 1998 5426 5432
2. R.S. Bitner, A.L. Nikkel, P. Curzon, D.L. Donnelly-Roberts, P.S. Puttfarcken, M. Namovic, I.C. Jacobs, M.D. Meyer, and M.W. Decker Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat Brain Res. 871 2000 66 74
3. J. Boulter, J. Connolly, E. Deneris, D. Goldman, S. Heinemann, and J. Patrick Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family Proc. Natl. Acad. Sci. U. S. A. 84 1987 7763 7767
4. W. Brysch The design of appropriate control experiments to ensure specificity in antisense oligonucleotide function R.A. Leslie A.J. Hunter H.A. Robertson Antisense technology in the central nervous system 1999 Oxford University Press Oxford 21 40
5. S.A. Bustin Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays J. Mol. Endocrinol. 25 2000 169 193
6. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal. Biochem. 162 1987 156 159
7. K.H. Cox, D.V. DeLeon, L.M. Angerer, and R.C. Angerer Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes Dev. Biol. 101 1984 485 502
8. M.I. Damaj, S.P. Welch, and B.R. Martin In vivo pharmacological effects of dihydro-beta-erythroidine, a nicotinic antagonist, in mice Psychopha rmacology (Berl.) 117 1995 67 73
9. M.I. Damaj, W. Glassco, M. Dukat, and B.R. Martin Pharmacological characterization of nicotine-induced seizures in mice J. Pharmacol. Exp. Ther. 291 1999 1284 1291
10. M.W. Decker, J.D. Brioni, A.W. Bannon, and S.P. Arneric Diversity of neuronal nicotinic acetylcholine receptors: lessons from behavior and implications for CNS therapeutics Life Sci. 56 1995 545 570
11. C.M. Flores, R.M. DeCamp, S. Kilo, S.W. Rogers, and K.M. Hargreaves Neuronal nicotinic receptor expression in sensory neurons of the rat trigeminal ganglion: demonstration of alpha3beta4, a novel subtype in the mammalian nervous system J. Neurosci. 16 1996 7892 7901
12. D. Franceschini, A. Orr-Urtreger, W. Yu, L.Y. Mackey, R.A. Bond, D. Armstrong, J.W. Patrick, A.L. Beaudet, and M. De Biasi Altered baroreflex responses in alpha7 deficient mice Behav. Brain Res. 113 2000 3 10
13. R.C. Hogg, and D. Bertrand Regulating the regulators: the role of nicotinic acetylcholine receptors in human epilepsy Drug News Perspect. 16 2003 261 266
14. T.A. Kuntzweiler, S.P. Arneric, and D.L. Donnelly-Roberts Rapid assessment of ligand actions with nicotinic acetylcholine receptors using calcium dynamics and FLIPR Drug Dev. Res. 44 1998 14 20
15. I. Lebedeva, and C.A. Stein Antisense oligonucleotides: promise and reality Annu. Rev. Pharmacol. Toxicol. 41 2001 403 419
16. N. Le Novere, M. Zoli, and J.P. Changeux Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain Eur. J. Neurosci. 8 1996 2428 2439
17. N. Le Novere, M. Zoli, C. Lena, R. Ferrari, M.R. Picciotto, E. Merlo-Pich, and J.P. Changeux Involvement of alpha6 nicotinic receptor subunit in nicotine-elicited locomotion, demonstrated by in vivo antisense oligonucleotide infusion NeuroReport 10 1999 2497 2501
18. L.M. Marubio, M. del Mar Arroyo-Jimenez, M. Cordero-Erausquin, C. Lena, N. Le Novere, A. de Kerchove d'Exaerde, M. Huchet, M.I. Damaj, and J.P. Changeux Reduced antinociception in mice lacking neuronal nicotinic receptor subunits Nature 398 1999 805 810
19. J.M. McIntosh, S. Gardner, S. Luo, J.E. Garrett, and D. Yoshikami Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function Eur. J. Pharmacol. 393 2000 205 208
20. K.M. Merchant, D.J. Dobie, and D.M. Dorsa Expression of the proneurotensin gene in the rat brain and its regulation by antipsychotic drugs Ann. N. Y. Acad. Sci. 668 1992 54 69
21. A.L. Nikkel, R.S. Bitner, P. Curzon, and M.W. Decker Differentiation of peripheral versus central nicotinic acetylcholine receptor antagonism in the rat Soc. Neurosci. Abstr. 25 1999 2239
22. R. Paylor, M. Nguyen, J.N. Crawley, J. Patrick, A. Beaudet, and A. Orr-Urtreger Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice Learn. Mem. 5 1998 302 316
23. M.R. Picciotto, M. Zoli, R. Rimondini, C. Lena, L.M. Marubio, E.M. Pich, K. Fuxe, and J.P. Changeux Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine Nature 391 1998 173 177
24. D. Platika, M.H. Boulos, L. Baizer, and M.C. Fishman Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells Proc. Natl. Acad. Sci. U. S. A. 82 1985 3499 3503
25. T.P. Prakash, A.M. Kawasaki, A.S. Fraser, G. Vasquez, and M. Manoharan Synthesis of 2′-O-[2-[(N,N-dimethylamino)oxy]ethyl] modified nucleosides and oligonucleotides J. Org. Chem. 67 2002 357 369
26. P.S. Puttfarcken, A.M. Manelli, S.P. Arneric, and D.L. Donnelly-Roberts Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells J. Neurochem. 69 1997 930 938
27. P.S. Puttfarcken, I. Jacobs, and C.R. Faltynek Characterization of nicotinic acetylcholine receptor-mediated [(3)H]-dopamine release from rat cortex and striatum Neuropharmacology 39 2000 2673 2680
28. T. Ren, and S.M. Sagar Induction of c-fos immunostaining in the rat brain after the systemic administration of nicotine Brain Res. Bull. 29 1992 589 597
29. I.P. Stolerman Behavioural pharmacology of nicotine: implications for multiple brain nicotinic receptors Ciba Found. Symp. 152 1990 3 16 (discussion 16â€"22)
30. E. Wada, K. Wada, J. Boulter, E. Deneris, S. Heinemann, J. Patrick, and L.W. Swanson Distribution of alpha 2, alpha 3, alpha 4, and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat J. Comp. Neurol. 284 1989 314 335
31. K. Watanabe, K. Hashimoto, T. Nishimura, K. Tsunashima, and Y. Minabe Expression of fos protein in rat brain following administration of a nicotinic acetylcholine receptor agonist epibatidine Brain Res. 797 1998 135 142
32. P. Whiteaker, M. Jimenez, J.M. McIntosh, A.C. Collins, and M.J. Marks Identification of a novel nicotinic binding site in mouse brain using [(125)I]-epibatidine Br. J. Pharmacol. 131 2000 729 739
33. P. Whiteaker, J.M. McIntosh, S. Luo, A.C. Collins, and M.J. Marks 125I-alpha-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain Mol. Pharmacol. 57 2000 913 925
34. P. Whiteaker, C.G. Peterson, W. Xu, J.M. McIntosh, R. Paylor, A.L. Beaudet, A.C. Collins, and M.J. Marks Involvement of the alpha3 subunit in central nicotinic binding populations J. Neurosci. 22 2002 2522 2529
35. W. Xu, S. Gelber, A. Orr-Urtreger, D. Armstrong, R.A. Lewis, C.N. Ou, J. Patrick, L. Role, M. De Biasi, A.L. Beaudet, and K. Dineley-Miller Megacystis, mydriasis, and ion channel defect in mice lacking the alpha3 neuronal nicotinic acetylcholine receptor Proc. Natl. Acad. Sci. U. S. A. 96 1999 5746 5751