Thio arsenosugars identified as natural constituents of mussels by liquid chromatography-mass spectrometry

Chemical Communications

Volumn , Issue 16, 2004, Pages 1824-1825

  Schmeisser, Ernst ^a   Raml, Reingard ^a   Francesconi, Kevin A ^a   Kuehnelt, Doris ^a   Lindberg, Anna Lena ^b   Sörös, Csilla ^c   Goessler, Walter ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b KAROLINSKA INSTITUTE   (Sweden)

^c BKAE University   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC DERIVATIVE; ARSENOBETAINE; CACODYLIC ACID; CARBOHYDRATE DERIVATIVE; ORGANOARSENIC DERIVATIVE; PROPIONIC ACID DERIVATIVE; THIO ARSENOSUGAR; TRIMETHYLARSONIOPROPIONATE; UNCLASSIFIED DRUG;

ALGA; ARTICLE; BIOTRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLLUSC; MUSSEL; NONHUMAN;

EID: 4644244384     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b406917j     Document Type: Article

References (12)

1. J. S. Edmonds, K. A. Francesconi, J. R. Cannon, C. L. Raston, B. W. Skelton and A. H. White, Tetrahedron Lett., 1977, 18, 1543-1546.
2. K. A. Francesconi and J. S. Edmonds, Adv. Inorg. Chem., 1997, 44, 147-189.
3. M. S. Ma and X. C. Le, Clin. Chem., 1998, 44, 539-550.
4. K. A. Francesconi, R. Tanggaard R, C. J. McKenzie and W. Goessler, Clin. Chem., 2002, 48, 92-101.
5. -1 and 10 μl or 20 μl injection volumes were used in all cases. Selective arsenic detection was performed with ICP MS (Agilent 4500 or 7500c) at m/z 75.
6. -1 dry mass) with water (5.0 ml) overnight. The liquor (neat, untreated) was also analysed and showed the same pattern of arsenic species.
7. 2 (20 μl, 30% solution) was added to 300 μl of the extract.
8. H. R. Hansen, R. Pickford, J. Thomas-Oates, M. Jaspars and J. Feldmann, Angew. Chem., Int. Ed., 2004, 43, 337-340.
9. 2S was bubbled for several minutes through an aqueous solution containing arsenosugar 1 (30 μg As in 10 ml) or arsenosugar 2 (1 μg As in 1 ml), which resulted in essentially quantitative conversion to the respective thio compounds (as determined by HPLC-ICP MS).
10. -1 and injection volume was 10 μl. Electrospray ionisation and mass detection was performed in positive ion mode with an Agilent G1946D single quadrupole MS.
11. Optimised fragmenter voltages for standard thio arsenicals 3 and 4 for protonated molecular ions and product ions were: m/z 345 & 347, 499 & 501 (100 V); 253 & 255 (150 V); 107 (250 V) 91 (400 V).
12. D. Kuehnelt, W. Goessler and K. A. Francesconi, Rapid Commun. Mass Spectrom., 2002, 17, 654-659.