Rilmenidine sympatholytic activity preserves mental and orthostatic sympathetic response and epinephrine secretion;La rilménidine préserve les réponses sympathiques au stress mental expérimental et à l'orthostatisme

Archives des Maladies du Coeur et des Vaisseaux

Volumn 97, Issue 7-8, 2004, Pages 786-792

  Esler, M ^b   Lux, A ^b   Jennings, G ^b   Hastings, J ^b   Socratous, F ^b   Lambert, G ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; IMIDAZOLINE DERIVATIVE; NORADRENALIN; PLACEBO; RILMENIDINE;

ADRENAL FUNCTION; ADRENAL MEDULLA; ADRENALIN RELEASE; ADULT; AGED; ARTICLE; BLOOD PRESSURE; BRAIN STEM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG CLEARANCE; DRUG MECHANISM; DRUG METABOLISM; EXPERIMENTAL ANIMAL; FEMALE; HEAD TILTING; HUMAN; MALE; MENTAL STRESS; PHYSICAL ACTIVITY; RANDOMIZED CONTROLLED TRIAL; REST; SUPINE POSITION; SYMPATHETIC TONE;

ADULT; AGED; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; OXAZOLES; PLACEBOS; STRESS, PSYCHOLOGICAL; SYMPATHETIC NERVOUS SYSTEM; TILT-TABLE TEST;

EID: 4644244052     PISSN: 00039683     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

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3. Tibirica EJ, Feldman C, Mermet C, Monassier F, Gonon F, Bousquet P. Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline-preferring receptors. Eur J Pharmacol 1991; 209: 213-21.
4. Roegel JC, Yannoulis N, De Jong W, Feldman J, Bousquet P. Preventive effect of rilmenidine on the occurrence of neurogenic ventricular arrhythmias in rabbits. J Hypertens 1998; 16 (Suppl. 3): S39-S43.
5. Medvedev OS, Esler MD, Angus JA, Cox HS, Eisenhofer G. Simultaneous determination of plasma noradrenaline and adrenaline kinetics: responses to nitroprusside-induced hypotension and 2-deoxyglucose-induced glucopenia in the rabbit. Naunyn Schmiedebergs Arch Pharmacol 1990; 341: 192-9.
6. Esler M, Jennings G, Lambert G, Meredith I, Horne M, Eisenhofer G. Overflow of catecholamine neurotransmitters to the circulation: Source, fate and functions. Physiol Rev 1990; 70: 963-85.
7. Wallin BG, Esler M, Dorward P et al. Simultaneous measurements of cardiac norepinephrine spillover and sympathetic outflow to skeletal muscle in humans. J Physiol (Lond) 1992; 453: 45-56.
8. Meredith IT, Eisenhofer G, Lambert GW, Jennings GL, Esler MD. Plasma noradrenaline responses to head-up tilt are misleading in autonomic failure. Hypertension 1992; 19: 628-33.
9. Schlaich MP, Kaye DM, Lambert E, Sommerville M, Sactratous F, Esler MD. Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy. Circulation 2003; 108: 560-5.
10. Reid J. Update on rilmenidine: Clinical benefits on sympathetic nervous system, 11 imidazoline receptors, hypertension and metabolic disorders. Am J Hypertens 2001; 14: 322S-324S.