In vitro studies on the evaluation of mycotoxin detoxifying agents for their efficacy on deoxynivalenol and zearalenone

Archives of Animal Nutrition

Volumn 58, Issue 4, 2004, Pages 311-324

  Doll S ^a   Danicke S ^a   Valenta, H ^a   Flachowsky, G ^a  

^a INSTITUTE FOR EPIDEMIOLOGY AND PATHOGEN DIAGNOSTICS   (Germany)

Author keywords

Adsorbents; Deoxynivalenol; Detoxification; In vitro; Mycotoxins; Zearalenone

Indexed keywords

ACTIVATED CARBON; ALUMINUM DERIVATIVE; BENTONITE; COLESTYRAMINE; FOOD ADDITIVE; MYCOTOXIN; VOMITOXIN; ZEARALENONE;

ADSORPTION; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETOXIFICATION; GASTROINTESTINAL TRACT; INTESTINE TRANSIT TIME; NONHUMAN; PH; REACTION TIME; SENSITIVITY ANALYSIS; STATISTICAL ANALYSIS; SWINE; TEMPERATURE; TOXIN ANALYSIS;

ADSORPTION; ALUMINUM SILICATES; ANIMAL FEED; ANIMALS; ANION EXCHANGE RESINS; BUFFERS; CHARCOAL; CHOLESTYRAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGENS, NON-STEROIDAL; FOOD ADDITIVES; FOOD CONTAMINATION; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; MYCOTOXINS; SWINE; TIME FACTORS; TREATMENT OUTCOME; TRICHOTHECENES; ZEARALENONE;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 4644242292     PISSN: 1745039X     EISSN: None     Source Type: Journal    
DOI: 10.1080/00039420412331273268     Document Type: Article

References (28)

1. Abdelhamid, A.M., Elshawaf, I., Elayoty, S.A., Ali, M.M. and Gamil, T. (1990) Effect of low-level of dietary aflatoxins on Baladi rabbits. Arch. Anim. Nutr., 40, 517-537.
2. Avantaggiato, G., Havenaar, R. and Visconti, A. (2003) Assessing the zearalenone-binding activity of adsorbent materials during passage through a dynamic in vitro gastrointestinal model. Food Chem. Toxicol., 41, 1283-1290.
3. Biehl, M.L., Prelusky, D.B., Koritz, G.D., Hartin, K.E., Buck, W.B. and Trenholm, H.L. (1993) Biliary excretion and enterohepatic cycling of zearalenone in immature pigs. Toxicol. Appl. Pharm., 121, 152-159.
4. Bottalico, A. and Perrone, G. (2002) Toxigenic Fusarium species and mycotoxins associated with head blight in small-grain cereals in Europe. Eur. J. Plant Pathol., 108, 611-624.
5. Clemens, E.T., Stevens, C.E. and Southworth, M. (1975) Sites of organic acid production and pattern of digesta movement in the gastrointestinal tract of swine. J. Nutr., 105, 759-768.
6. Dänicke, S., Dusel, G., Jeroch, H. and Kluge, H. (1999) Factors affecting efficiency of NSP-degrading enzymes in rations for pigs and poultry. Agrobiol. Res., 52, 1-24.
7. Dänicke, S., Valenta, H. and Ueberschär, K.-H. (2000) Risikoabschätzung und Vermeidungsstrategien bei der Fütterung. In: Dänicke, S. und Oldenburg, E. (Eds.) Risikofaktoren für die Fusariumtoxinbildung und Vermeidungsstrategien bei der Futtermittelerzeugung und Fütterung. Landbauforsch. Völk. Sonderheft Nr. 216, pp. 35-139.
8. Dänicke, S., Gädeken, D., Ueberschär, K.-H., Meyer, U. and Scholz, H. (2002a) Effects of Fusarium toxin contaminated wheat and of a detoxifying agent on performance of growing bulls, on nutrient digestibility in wethers and on the carry over of zearalenone. Arch. Anim. Nutr., 56, 245-261.
9. Dänicke, S., Ueberschär, K.-H., Halle, I., Matthes, S., Valenta, H. and Flachowsky, G. (2002b) Effect of addition of a detoxifying agent to laying-hen diets containing uncontaminated or Fusarium toxin-contaminated maize in performance of hens and on carry-over of zearalenone. Poult. Sci., 81, 1671-1680.
10. Dänicke, S., Valenta, H. and Döll, S. (2004a) On the toxicokinetics and the metabolism of deoxynivalenol (DON) in the pig. Arch. Anim. Nutr., 58, 169-180.
11. Dänicke, S., Valenta, H., Döll, S., Ganter, M. and Flachowsky, G. (2004b) On the effectiveness of a detoxifying agent in preventing fusariotoxicosis in fattening pigs. Anim. Feed Sci. Technol., 114, 141-157.
12. Döll, S., Gericke, S., Dänicke, S., Raila, J., Ueberschär, K.-H., Valenta, H., Schnurrbusch, U., Schweigert, F.J. and Flachowsky, G. (2004) Effects of Fusarium toxin contaminated maize in diets for piglets and the efficacy of a modified alumosilicate as a detoxifying agent. J. Anim. Physiol. Anim. Nutr. (accepted).
13. D'Mello, J.P.F., Placinta, C.M. and Macdonald, A.M.C. (1999) Fusarium mycotoxins: a review of global implications for animal health, welfare and productivity. Anim. Feed Sci. Technol., 80, 183-205.
14. Fink-Gremmels, J. (1999) Mycotoxins: their implications for human and animal health. Vet. Q., 21, 115-120.
15. Karlovsky, P. (1999) Biological detoxification of fungal toxins and its use in plant breeding, feed and food production. Natural Toxins, 7, 1-23.
16. Lemke, S.L., Grant, P.G. and Phillips, T.D. (1998) Adsorption of zearalenone by organophilic montmorillonite clay. J. Agric. Food Chem., 46, 3789-3796.
17. Logrieco, A., Mule, G., Moretti, A. and Bottalico, A. (2002) Toxigenic Fusarium species and mycotoxins associated with maize ear rot in Europe. Eur. J. Plant Pathol., 108, 597-609.
18. Oldenburg, E., Valenta, H. and Sator, Ch. (2000) Risikoabschätzung und Vermeidungsstrategien bei der Futtermittelerzeugung. In: Dänicke, S. und Oldenburg, E. (Eds.) Risikofaktoren für die Fusariumtoxinbildung und Vermeidungsstrategien bei der Futtermittelerzeugung und Fütterung. Landbauforsch. Völk. Sonderheft Nr. 216, pp. 5-34.
19. Osweiler, G.D. (2000) Mycotoxins. Contemporary issues of food animal health and productivity. Vet. Clin. North Am. Food Anim Pract., 16, 511-530.
20. Ramos, A.J., Fink-Gremmels, J. and Hernandez, E. (1996a) Prevention of toxic effects of mycotoxins by means of nonnutritive adsorbent compounds. J. Food Protect., 59, 631-641.
21. Ramos, A.J., Hernandez, E., Pladelfina, J.M. and Merino, M. (1996b) Intestinal-absorption of zearalenone and in-vitro study of nonnutritive sorbent materials. Int. J. Pharm., 128, 129-137.
22. Sabater Vilar, M. (2003) Assessment and intervention of food- and feed-borne mycotoxicoses. PhD Thesis. Department of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, The Netherlands.
23. StatSoft Inc. (1994) Statistica for the Windows™ Operating System. Tulsa, OK (USA).
24. Stedronsky, E.R. (1994) Interaction of bile acids and cholesterol with non-systemic agents having hypocholesterolemic properties. Biochim. Biophys. Acta, 1210, 255-287.
25. Thimm, N., Schwaighofer, B., Ottner, F., Fröschl, H., Greifeneder, S. and Binder, E.M. (2001) Adsorbtion of mycotoxins. Mycotox. Res., 17A, 219-223.
26. Tomasevic-Canovic, M., Dankovic, A., Rottinghouse, G., Matijasevic, S. and Duricic, M. (2003) Surfactant modified zeolites - new efficient adsorbents for mycotoxins. Micropor. Mesopor. Mat., 61, 173-180.
27. Valenta, H. (1999) Zum Einfluß des Extraktionsmittels auf die Bestimmung von Zearalenon in Getreide. VDLUFA-Kongreßband 1999, Halle/Saale, VDLUFA-Schriftenreihe 52/1999, 429-432.
28. Valenta, H., Dänicke, S. and Wolff, J. (2002) Vergleich einer HPLC- und einer ELISA- Methode zur Bestimmung von Deoxynivalenol in Mühlenstäuben, Kleien und Getreide. VDLUFA-Kongreßband 2002, Leipzig, VDLUFA-Schriftreihe 58/2003, 675-679.