Pharmacokinetics and dose proportionality of extended-release metformin following administration of 1000, 1500, 2000 and 2500 mg in healthy volunteers

Biopharmaceutics and Drug Disposition

Volumn 25, Issue 6, 2004, Pages 261-263

  Cullen, Edward ^a,b   Liao, James ^a,b   Lukacsko, Peter ^a,b   Niecestro, Robert ^a,b   Friedhoff, Lawrence ^a,b  

^a Aura Laboratories Inc   (United States)

^b NONE

Author keywords

Dose proportionality; Extended release formulation; Metformin; Pharmacokinetics; Tolerability

Indexed keywords

METFORMIN;

AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG EXPOSURE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; VOLUNTEER;

ADMINISTRATION, ORAL; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METFORMIN;

EID: 4644237685     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.407     Document Type: Article

References (8)

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