[1,2-bis(2,6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II) complexes, compounds for the endocrine therapy of breast cancer - Mode of action II: Contribution of drug inactivation, cellular drug uptake and sterical factors in the drug-target interaction to the antitumor activity

Archiv der Pharmazie

Volumn 337, Issue 6, 2004, Pages 349-359

  Schertl, Sabine ^a   Hartmann, Rolf W ^b   Batzl Hartmann, Christine ^b   Bernhardt, Günther ^a   Spruß, Thilo ^a   Beckenlehner, Karin ^a   Koch, Marion ^a   Krauser, Rudolf ^a   Schlemmer, Richard ^a   Gust, Ronald ^c   Schönenberger, Helmut ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Anti breast cancer activity; Drug accumulation; Inactivation kinetics; Reactivity

Indexed keywords

[1,2 BIS(2,6 DIFLUORO 3 HYDROXYPHENYL)ETHYLENEDIAMINE]PLATINUM; [1,2 BIS(4 FLUOROPHENYL)ETHYLENEDIAMINE]PLATINUM; AQUA[1,2 BIS(2,6 DIFLUORO 3 HYDROXYPHENYL)ETHYLENEDIAMINE]SULFATOPLATINUM; CARBOPLATIN; CISPLATIN; DNA; ESTROGEN; GUANINE; PLASMA PROTEIN; PLATINUM COMPLEX; UNCLASSIFIED DRUG; (1,2 BIS(2, 6 DIFLUORO 3 HYDROXYPHENYL)ETHYLENE DIAMINE)PLATINUM(II); (1,2-BIS(2, 6-DIFLUORO-3-HYDROXYPHENYL)ETHYLENE-DIAMINE)PLATINUM(II); ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; DRUG UPTAKE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; ABSORPTION; ANIMAL; CELL DEATH; CHEMISTRY; COMPARATIVE STUDY; EXPERIMENTAL NEOPLASM; FEMALE; METABOLISM; NEOPLASM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ABSORPTION; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CELL DEATH; CELL LINE, TUMOR; DNA, NEOPLASM; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; NEOPLASMS, HORMONE-DEPENDENT; ORGANOPLATINUM COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4644235983     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.200300856     Document Type: Article

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