메뉴 건너뛰기




Volumn 2, Issue 3, 2004, Pages 143-155

Aerosols for macromolecule delivery: Design challenges and solutions

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA INTERFERON; ANTIASTHMATIC AGENT; BETA INTERFERON; CALCITONIN; CYCLOSPORIN; DIMETHYL SULFOXIDE; DORNASE ALFA; EXCIPIENT; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH HORMONE; HEPARIN; INSULIN; INTERLEUKIN 2; INTERLEUKIN 4 ANTAGONIST; LEUPRORELIN; LUNG SURFACTANT; MACROGOL; PARATHYROID HORMONE; PLASMID DNA; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE DERIVATIVE;

EID: 4644232980     PISSN: 11759038     EISSN: None     Source Type: Journal    
DOI: 10.2165/00137696-200402030-00001     Document Type: Review
Times cited : (14)

References (83)
  • 2
    • 0027528677 scopus 로고
    • Lower respiratory tract structure of laboratory animals and humans: Dosimetry implications
    • Miller FJ, Mercer RR, Crapo JD. Lower respiratory tract structure of laboratory animals and humans: dosimetry implications. Aerosol Sci Technol 1993; 18: 257-71
    • (1993) Aerosol. Sci. Technol. , vol.18 , pp. 257-271
    • Miller, F.J.1    Mercer, R.R.2    Crapo, J.D.3
  • 3
    • 0014260277 scopus 로고
    • Morphology of the bronchial tree in man
    • Horsfield K, Cummings G. Morphology of the bronchial tree in man. J Appl Physiol 1968; 24:373-91
    • (1968) J. Appl. Physiol. , vol.24 , pp. 373-391
    • Horsfield, K.1    Cummings, G.2
  • 4
    • 0019223334 scopus 로고
    • Models of human lung airways and their application to inhaled particle deposition
    • Yeh H, Schum GM. Models of human lung airways and their application to inhaled particle deposition. Bull Math Biol 1980; 42:461-80
    • (1980) Bull Math. Biol. , vol.42 , pp. 461-480
    • Yeh, H.1    Schum, G.M.2
  • 5
    • 0017879956 scopus 로고
    • The normal human lung: Ultrastructure and morphometric estimation of diffusion capacity
    • Gehr P, Bachofen M, Weibel ER. The normal human lung: ultrastructure and morphometric estimation of diffusion capacity. Respir Physiol 1978; 32: 121-40
    • (1978) Respir. Physiol. , vol.32 , pp. 121-140
    • Gehr, P.1    Bachofen, M.2    Weibel, E.R.3
  • 6
    • 0028856079 scopus 로고
    • Alveolar lining layer is thin and continuous: Low temperature scanning electron microscopy of rat lung
    • Bastacky J, Lee CY, Goerke J, et al. Alveolar lining layer is thin and continuous: low temperature scanning electron microscopy of rat lung. J Appl Physiol 1995; 7: 1615-28
    • (1995) J. Appl. Physiol. , vol.7 , pp. 1615-1628
    • Bastacky, J.1    Lee, C.Y.2    Goerke, J.3
  • 7
    • 0020146129 scopus 로고
    • Cell number and cell characteristics of normal human lung
    • Crapo JD, Barry BE, Gehr P, et al. Cell number and cell characteristics of normal human lung. Am Rev Respir Dis 1983; 125: 332-7
    • (1983) Am. Rev. Respir. Dis. , vol.125 , pp. 332-337
    • Crapo, J.D.1    Barry, B.E.2    Gehr, P.3
  • 8
    • 0026634773 scopus 로고
    • The pharmacokinetics of pulmonary delivered insulin: A comparison of intra-tracheal and aerosol administration to the rabbit
    • Colthorpe P, Farr SJ, Taylor G, et al. The pharmacokinetics of pulmonary delivered insulin: a comparison of intra-tracheal and aerosol administration to the rabbit. Pharm Res 1992; 9: 765-8
    • (1992) Pharm. Res. , vol.9 , pp. 765-768
    • Colthorpe, P.1    Farr, S.J.2    Taylor, G.3
  • 9
    • 0028931388 scopus 로고
    • The influence of regional deposition on the pharmacokinetics of pulmonary-delivered human growth hormone in rabbits
    • Colthorpe P, Farr SJ, Smith IJ, et al. The influence of regional deposition on the pharmacokinetics of pulmonary-delivered human growth hormone in rabbits. Pharm Res 1995; 12: 356-9
    • (1995) Pharm. Res. , vol.12 , pp. 356-359
    • Colthorpe, P.1    Farr, S.J.2    Smith, I.J.3
  • 11
    • 33745255214 scopus 로고
    • Uber inhalation von insulin
    • Gänsslen M. Uber inhalation von insulin. Klin Wochenschr 1925; 4: 71-2
    • (1925) Klin. Wochenschr. , vol.4 , pp. 71-72
    • Gänsslen, M.1
  • 12
    • 0020961251 scopus 로고
    • Measurements of pulmonary epithelial permeability in vivo
    • Effros RM, Mason GR. Measurements of pulmonary epithelial permeability in vivo. Am Rev Respir Dis 1983; 127: S59-65
    • (1983) Am. Rev. Respir. Dis. , vol.127
    • Effros, R.M.1    Mason, G.R.2
  • 13
    • 0020589977 scopus 로고
    • Relation between molecular weight and pulmonary absorption rate of lipid-insoluble compounds in neonatal and adult rats
    • Schanker LS, Hemberger JA. Relation between molecular weight and pulmonary absorption rate of lipid-insoluble compounds in neonatal and adult rats. Biochem Pharmacol 1983; 32: 2599-601
    • (1983) Biochem. Pharmacol. , vol.32 , pp. 2599-2601
    • Schanker, L.S.1    Hemberger, J.A.2
  • 14
    • 0022577075 scopus 로고
    • Species comparison of drug absorption from the lung after aerosol inhalation or intratracheal injection
    • Schanker LS, Mitchell EW, Brown RA. Species comparison of drug absorption from the lung after aerosol inhalation or intratracheal injection. Drug Metab Dispos 1986; 14: 79-88
    • (1986) Drug Metab. Dispos. , vol.14 , pp. 79-88
    • Schanker, L.S.1    Mitchell, E.W.2    Brown, R.A.3
  • 15
    • 0025339348 scopus 로고
    • Permeability of the respiratory tract to different-sized macromolecules after intratracheal instillation in young and adult rats
    • Folkesson HG, Westrom BR, Karlsson BW. Permeability of the respiratory tract to different-sized macromolecules after intratracheal instillation in young and adult rats. Acta Physiol Scand 1990; 139: 347-54
    • (1990) Acta Physiol. Scand. , vol.139 , pp. 347-354
    • Folkesson, H.G.1    Westrom, B.R.2    Karlsson, B.W.3
  • 16
    • 0028965126 scopus 로고
    • Pulmonary absorption of peptides and proteins
    • Wall DA. Pulmonary absorption of peptides and proteins. Drug Deliv 1995; 2: 1-20
    • (1995) Drug Deliv. , vol.2 , pp. 1-20
    • Wall, D.A.1
  • 17
    • 0031454495 scopus 로고    scopus 로고
    • Pulmonary drug delivery: Physiologic and mechanistic aspects
    • Yu J, Chien YW. Pulmonary drug delivery: physiologic and mechanistic aspects. Crit Rev Ther Drug Carrier Syst 1997; 14: 395-453
    • (1997) Crit. Rev. Ther. Drug Carrier Syst. , vol.14 , pp. 395-453
    • Yu, J.1    Chien, Y.W.2
  • 18
    • 0031910009 scopus 로고    scopus 로고
    • Breathing life into protein drugs
    • Patton JS. Breathing life into protein drugs. Nat Biotechnol 1998; 16: 141-3
    • (1998) Nat. Biotechnol. , vol.16 , pp. 141-143
    • Patton, J.S.1
  • 19
    • 0028087664 scopus 로고
    • Drug delivery via the respiratory tract
    • Byron PR, Patton JS. Drug delivery via the respiratory tract. J Aerosol Med 1994; 7: 49-75
    • (1994) J. Aerosol. Med. , vol.7 , pp. 49-75
    • Byron, P.R.1    Patton, J.S.2
  • 21
    • 0343058935 scopus 로고    scopus 로고
    • Mechanisms of macromolecule absorption by the lungs
    • Patton JS. Mechanisms of macromolecule absorption by the lungs. Adv Drug Deliv Rev 1996; 19: 3-36
    • (1996) Adv. Drug Deliv. Rev. , vol.19 , pp. 3-36
    • Patton, J.S.1
  • 22
    • 0035963943 scopus 로고    scopus 로고
    • Caveolae as potential macromolecule trafficking compartments within alveolar epithelium
    • Gumbleton M. Caveolae as potential macromolecule trafficking compartments within alveolar epithelium. Adv Drug Deliv Rev 2001; 49: 281-300
    • (2001) Adv. Drug Deliv. Rev. , vol.49 , pp. 281-300
    • Gumbleton, M.1
  • 23
    • 0001778198 scopus 로고
    • Pulmonary absorption of proteins: Influence of deposition site and competitive elimination processes
    • Dalby RN, Byron PR, Peart J, et al., editors. Buffalo Grove (IL): Interpharm Press
    • Taylor G, Colthorpe P, Farr SJ. Pulmonary absorption of proteins: influence of deposition site and competitive elimination processes. In: Dalby RN, Byron PR, Peart J, et al., editors. Respiratory drug delivery IV. Buffalo Grove (IL): Interpharm Press, 1994: 25-37
    • (1994) Respiratory Drug Delivery IV , pp. 25-37
    • Taylor, G.1    Colthorpe, P.2    Farr, S.J.3
  • 25
    • 0031045338 scopus 로고    scopus 로고
    • The intrapulmonary half-life and safety of aerosolized alphal-protease inhibitor in normal volunteers
    • Vogelmeier C, Kirlath I, Warrington S, et al. The intrapulmonary half-life and safety of aerosolized alphal-protease inhibitor in normal volunteers. Am J Respir Crit Care Med 1997; 155: 536-41
    • (1997) Am. J. Respir. Crit. Care Med. , vol.155 , pp. 536-541
    • Vogelmeier, C.1    Kirlath, I.2    Warrington, S.3
  • 26
    • 0034744066 scopus 로고    scopus 로고
    • Inhalation of [123I]alpha 1-protease inhibitor: Toward a new therapeutic concept of alphal-protease inhibitor deficiency?
    • Kropp J, Wencker M, Hotze A, et al. Inhalation of [123I]alpha 1-protease inhibitor: toward a new therapeutic concept of alphal-protease inhibitor deficiency? J Nucl Med 2001; 42: 744-51
    • (2001) J. Nucl. Med. , vol.42 , pp. 744-751
    • Kropp, J.1    Wencker, M.2    Hotze, A.3
  • 27
    • 0032821440 scopus 로고    scopus 로고
    • Influence of the technological parameters of ultrasonic nebulisation on the nebulisation quality of alphal protease inhibitor (alpha1PI)
    • Flament MP, Leterme P, Gayot A. Influence of the technological parameters of ultrasonic nebulisation on the nebulisation quality of alphal protease inhibitor (alpha1PI). Int J Pharm 1999; 189: 197-204
    • (1999) Int. J. Pharm. , vol.189 , pp. 197-204
    • Flament, M.P.1    Leterme, P.2    Gayot, A.3
  • 28
    • 0030463020 scopus 로고    scopus 로고
    • Opportunities for the use of aerosolized alpha 1-antitrypsin for the treatment of cystic fibrosis
    • Allen ED. Opportunities for the use of aerosolized alpha 1-antitrypsin for the treatment of cystic fibrosis. Chest 1996; 110: 256S-60S
    • (1996) Chest , vol.110
    • Allen, E.D.1
  • 29
    • 0037695175 scopus 로고    scopus 로고
    • Deoxyribonuclease inhalation
    • Adjei AL, Gupta PK, editors. New York: Marcel Dekker Inc
    • Gonda I. Deoxyribonuclease inhalation. In: Adjei AL, Gupta PK, editors. Inhalation delivery of therapeutic peptides and proteins. New York: Marcel Dekker Inc., 1997: 355-65
    • (1997) Inhalation Delivery of Therapeutic Peptides and Proteins , pp. 355-365
    • Gonda, I.1
  • 30
    • 0036708205 scopus 로고    scopus 로고
    • Dornase alfa in early cystic fibrosis lung disease
    • Robinson PJ. Dornase alfa in early cystic fibrosis lung disease. Pediatr Pulmonol 2002; 34: 237-41
    • (2002) Pediatr. Pulmonol. , vol.34 , pp. 237-241
    • Robinson, P.J.1
  • 31
    • 0038311930 scopus 로고    scopus 로고
    • Current status of gene therapy for inherited lung diseases
    • Driskell RA, Engelhardt JF. Current status of gene therapy for inherited lung diseases. Annu Rev Physiol 2003; 65: 585-612
    • (2003) Annu. Rev. Physiol. , vol.65 , pp. 585-612
    • Driskell, R.A.1    Engelhardt, J.F.2
  • 32
    • 0037027911 scopus 로고    scopus 로고
    • Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis
    • Ferrari S, Geddes DM, Alton EW. Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis. Adv Drug Deliv Rev 2002; 54: 1373-93
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1373-1393
    • Ferrari, S.1    Geddes, D.M.2    Alton, E.W.3
  • 33
    • 0034003204 scopus 로고    scopus 로고
    • Physical stability and in-vitro gene expression efficiency of nebulised lipid-peptide-DNA complexes
    • Birchall JC, Kellaway IW, Gumbleton M. Physical stability and in-vitro gene expression efficiency of nebulised lipid-peptide-DNA complexes. Int J Pharm 2000; 197: 221-31
    • (2000) Int. J. Pharm. , vol.197 , pp. 221-231
    • Birchall, J.C.1    Kellaway, I.W.2    Gumbleton, M.3
  • 34
    • 0029815814 scopus 로고    scopus 로고
    • Plasmid DNA molecules complexed with cationic liposomes are protected from degradation by nucleases and shearing by aerosolisation
    • Crook K, McLachlan G, Stevenson BJ, et al. Plasmid DNA molecules complexed with cationic liposomes are protected from degradation by nucleases and shearing by aerosolisation. Gene Ther 1996; 3: 834-9
    • (1996) Gene Ther. , vol.3 , pp. 834-839
    • Crook, K.1    McLachlan, G.2    Stevenson, B.J.3
  • 35
    • 0036363610 scopus 로고    scopus 로고
    • Jet nebulization of PEI/DNA polyplexes: Physical stability and in vitro gene delivery efficiency
    • Rudolph C, Muller RH, Rosenecker J. Jet nebulization of PEI/DNA polyplexes: physical stability and in vitro gene delivery efficiency. J Gene Med 2002; 4: 66-74
    • (2002) J. Gene Med. , vol.4 , pp. 66-74
    • Rudolph, C.1    Muller, R.H.2    Rosenecker, J.3
  • 36
    • 0036632415 scopus 로고    scopus 로고
    • Preparation of dry powder dispersions for non-viral gene delivery by freeze-drying and spray-drying
    • Seville PC, Kellaway IW, Birchall JC. Preparation of dry powder dispersions for non-viral gene delivery by freeze-drying and spray-drying. J Gene Med 2002; 4: 428-37
    • (2002) J. Gene Med. , vol.4 , pp. 428-437
    • Seville, P.C.1    Kellaway, I.W.2    Birchall, J.C.3
  • 37
    • 0036451139 scopus 로고    scopus 로고
    • Aerosolization of lipoplexes using AERx pulmonary delivery system
    • [abstract]
    • Deshpande D, Blanchard J, Srinivasan S, et al. Aerosolization of lipoplexes using AERx pulmonary delivery system [abstract] AAPS PharmSci 2002; 4: E13
    • (2002) AAPS Pharm. Sci. , vol.4
    • Deshpande, D.1    Blanchard, J.2    Srinivasan, S.3
  • 40
    • 0010495811 scopus 로고    scopus 로고
    • Technical development of AERx diabetes management system: Essential characteristics for diabetes treatment with pulmonary insulin
    • Dalby RN, Byron PR, Peart J, et al., editors. Raleigh (NC): Davis Horwood International Publishing
    • Farr S, Reynolds D, Nat A, et al. Technical development of AERx diabetes management system: essential characteristics for diabetes treatment with pulmonary insulin. In: Dalby RN, Byron PR, Peart J, et al., editors. Respiratory drug delivery VIII. Raleigh (NC): Davis Horwood International Publishing, 2002: 51-9
    • (2002) Respiratory Drug Delivery VIII , pp. 51-59
    • Farr, S.1    Reynolds, D.2    Nat, A.3
  • 41
    • 0344712991 scopus 로고    scopus 로고
    • Feasibility studies with recombinant human granulocyte colony-stimulating factor
    • Adjei AL, Gupta PK, editors. New York: Marcel Dekker Inc
    • Niven RW. Feasibility studies with recombinant human granulocyte colony-stimulating factor. In: Adjei AL, Gupta PK, editors. Inhalation delivery of therapeutic peptides and proteins. New York: Marcel Dekker Inc., 1997: 413-52
    • (1997) Inhalation Delivery of Therapeutic Peptides and Proteins , pp. 413-452
    • Niven, R.W.1
  • 42
    • 0028332576 scopus 로고
    • Protein nebulization: I. Stability of lactate dehydrogenase and recombinant granulocyte-colony stimulating factor to air-jet nebulization
    • Niven RW, Ip AY, Mittelman SD, et al. Protein nebulization: I. Stability of lactate dehydrogenase and recombinant granulocyte-colony stimulating factor to air-jet nebulization, Int J Pharm 1994; 109: 17-26
    • (1994) Int. J. Pharm. , vol.109 , pp. 17-26
    • Niven, R.W.1    Ip, A.Y.2    Mittelman, S.D.3
  • 43
    • 0029914615 scopus 로고    scopus 로고
    • Protein nebulization: II. Stabilization of G-CSF to air-jet nebulization and the role of protectants
    • Niven RW, Prestrelski SJ, Treuheit MJ, et al. Protein nebulization: II. Stabilization of G-CSF to air-jet nebulization and the role of protectants. Int J Pharm 1996; 1127: 191-201
    • (1996) Int. J. Pharm. , vol.1127 , pp. 191-201
    • Niven, R.W.1    Prestrelski, S.J.2    Treuheit, M.J.3
  • 45
    • 0031780284 scopus 로고    scopus 로고
    • Effect of spray-drying and subsequent processing conditions on residual moisture content and physical/biochemical stability of protein inhalation powders
    • Ma YF, Nguyen PA, Andya JD, et al. Effect of spray-drying and subsequent processing conditions on residual moisture content and physical/biochemical stability of protein inhalation powders. Pharm Res 1998; 15: 768-75
    • (1998) Pharm. Res. , vol.15 , pp. 768-775
    • Ma, Y.F.1    Nguyen, P.A.2    Andya, J.D.3
  • 46
    • 0031008878 scopus 로고    scopus 로고
    • Spray-dried powders and powder blends of recombinant human deoxyribonuclease (rhDNase) for aerosol delivery
    • Chan HK, Clark A, Gonda I, et al. Spray-dried powders and powder blends of recombinant human deoxyribonuclease (rhDNase) for aerosol delivery. Pharm Res 1997; 14: 431-7
    • (1997) Pharm. Res. , vol.14 , pp. 431-437
    • Chan, H.K.1    Clark, A.2    Gonda, I.3
  • 47
    • 0007841187 scopus 로고    scopus 로고
    • Size reduction of peptides and proteins by jet-milling
    • Dalby RN, Byron PR, Farr SJ, editors. Buffalo Grove (IL): Interpharm Press
    • Phillips E, Allsopp E, Christensen T, et al. Size reduction of peptides and proteins by jet-milling. In: Dalby RN, Byron PR, Farr SJ, editors. Respiratory drug delivery VI. Buffalo Grove (IL): Interpharm Press, 1998: 161-8
    • (1998) Respiratory Drug Delivery VI , pp. 161-168
    • Phillips, E.1    Allsopp, E.2    Christensen, T.3
  • 48
    • 0035925635 scopus 로고    scopus 로고
    • A powder formulation of measles vaccine for aerosol delivery
    • LiCalsi C, Maniaci MJ, Christensen T, et al. A powder formulation of measles vaccine for aerosol delivery. Vaccine 2001; 19: 2629-36
    • (2001) Vaccine , vol.19 , pp. 2629-2636
    • LiCalsi, C.1    Maniaci, M.J.2    Christensen, T.3
  • 49
    • 0347689976 scopus 로고    scopus 로고
    • Clinical evaluation of inhaled insulin stabilized with trehalose
    • Dalby RN, Byron PR, Peart J, et al., editors. Raleigh (NC): Davis Horwood International Publishing
    • Hardy JG, Crew P, Osborne P, et al. Clinical evaluation of inhaled insulin stabilized with trehalose. In: Dalby RN, Byron PR, Peart J, et al., editors. Respiratory drug delivery VIII. Raleigh (NC): Davis Horwood International Publishing, 2002: 415-7
    • (2002) Respiratory Drug Delivery VIII , pp. 415-417
    • Hardy, J.G.1    Crew, P.2    Osborne, P.3
  • 50
    • 0031914743 scopus 로고    scopus 로고
    • Spray-drying of air-liquid interface sensitive recombinant human growth hormone
    • Ma YF, Nguyen PA, Hsu SW. Spray-drying of air-liquid interface sensitive recombinant human growth hormone. J Pharm Sci 1998; 87: 152-9
    • (1998) J. Pharm. Sci. , vol.87 , pp. 152-159
    • Ma, Y.F.1    Nguyen, P.A.2    Hsu, S.W.3
  • 51
    • 0032734092 scopus 로고    scopus 로고
    • Formulation and physical characterization of large porous particles for inhalation
    • Vanbever R, Mintzes JD, Wang J, et al. Formulation and physical characterization of large porous particles for inhalation. Pharm Res 1999; 16: 1735-42
    • (1999) Pharm. Res. , vol.16 , pp. 1735-1742
    • Vanbever, R.1    Mintzes, J.D.2    Wang, J.3
  • 53
    • 0345701503 scopus 로고    scopus 로고
    • Supercritical fluid processing of proteins: Lysozyme precipitation from aqueous solution
    • Moshashaee S, Bisrat M, Forbes RT, et al. Supercritical fluid processing of proteins: lysozyme precipitation from aqueous solution. J Pharm Pharmacol 2003; 55: 185-92
    • (2003) J. Pharm. Pharmacol. , vol.55 , pp. 185-192
    • Moshashaee, S.1    Bisrat, M.2    Forbes, R.T.3
  • 54
    • 0034495097 scopus 로고    scopus 로고
    • Generation of micro-particles of proteins for aerosol delivery using high pressure modified carbon dioxide
    • Bustami RT, Chan HK, Dehghani F, et al. Generation of micro-particles of proteins for aerosol delivery using high pressure modified carbon dioxide. Pharm Res 2000; 17: 1360-6
    • (2000) Pharm. Res. , vol.17 , pp. 1360-1366
    • Bustami, R.T.1    Chan, H.K.2    Dehghani, F.3
  • 55
    • 0346352236 scopus 로고    scopus 로고
    • Pulmonary delivery of novel insulin microspheres
    • Dalby RN, Byron PR, Peart J, et al., editors. Raleigh (NC): Davis Horwood International Publishing
    • Brown LR, Rasbba-Step J, Scott T, et al. Pulmonary delivery of novel insulin microspheres. In: Dalby RN, Byron PR, Peart J, et al., editors. Respiratory drug delivery VIII. Raleigh (NC): Davis Horwood International Publishing, 2002: 431-3
    • (2002) Respiratory Drug Delivery VIII , pp. 431-433
    • Brown, L.R.1    Rasbba-Step, J.2    Scott, T.3
  • 56
    • 4644313858 scopus 로고    scopus 로고
    • Development of a novel spray-drying technique to produce particles for aerosol delivery
    • Dalby RN, Byron PR, Peart J, et al., editors. Raleigh (NC): Davis Horwood International Publishing
    • Bhat MG, Hughes ML, Dobbins MA, et al. Development of a novel spray-drying technique to produce particles for aerosol delivery. In: Dalby RN, Byron PR, Peart J, et al., editors. Respiratory drug delivery VIII. Raleigh (NC): Davis Horwood International Publishing, 2002: 427-9
    • (2002) Respiratory Drug Delivery VIII , pp. 427-429
    • Bhat, M.G.1    Hughes, M.L.2    Dobbins, M.A.3
  • 57
    • 0012165208 scopus 로고    scopus 로고
    • Sustained delivery of insulin via the lung using Solidose technology
    • Dalby RN, Byron PR, Peart J, et al., editors. Raleigh (NC): Davis Horwood International Publishing
    • Blair J, Coghlan D, Langner E, et al. Sustained delivery of insulin via the lung using Solidose technology. In: Dalby RN, Byron PR, Peart J, et al., editors. Respiratory drug delivery VIII. Raleigh (NC): Davis Horwood International Publishing, 2002: 411-3
    • (2002) Respiratory Drug Delivery VIII , pp. 411-413
    • Blair, J.1    Coghlan, D.2    Langner, E.3
  • 58
    • 0037467167 scopus 로고    scopus 로고
    • Release mechanism of insulin encapsulated in trehalose ester derivative microparticles delivered via inhalation
    • Davidson IG, Langner EJ, Plowman SV, et al. Release mechanism of insulin encapsulated in trehalose ester derivative microparticles delivered via inhalation. Int J Pharm 2003; 254: 211-22
    • (2003) Int. J. Pharm. , vol.254 , pp. 211-222
    • Davidson, I.G.1    Langner, E.J.2    Plowman, S.V.3
  • 59
    • 0037151331 scopus 로고    scopus 로고
    • Modifying the release of leuprolide from spray dried OED microparticles
    • Alcock R, Blair JA, O'Mahony DJ, et al. Modifying the release of leuprolide from spray dried OED microparticles. J Control Release 2002; 82: 429-40
    • (2002) J. Control Release , vol.82 , pp. 429-440
    • Alcock, R.1    Blair, J.A.2    O'Mahony, D.J.3
  • 60
    • 0025233547 scopus 로고
    • Solute absorption from the airways of the isolated rat lung: II. Effect of surfactants on absorption of fluorescein
    • Niven RW, Byron PR. Solute absorption from the airways of the isolated rat lung: II. Effect of surfactants on absorption of fluorescein. Pharm Res 1990; 7: 8-13
    • (1990) Pharm. Res. , vol.7 , pp. 8-13
    • Niven, R.W.1    Byron, P.R.2
  • 61
    • 0027965843 scopus 로고
    • Study on pulmonary delivery of salmon calcitonin in rats: Effects of protease inhibitors and absorption enhancers
    • Kobayashi S, Kondo S, Juni K. Study on pulmonary delivery of salmon calcitonin in rats: effects of protease inhibitors and absorption enhancers. Pharm Res 1994; 11: 1239-43
    • (1994) Pharm. Res. , vol.11 , pp. 1239-1243
    • Kobayashi, S.1    Kondo, S.2    Juni, K.3
  • 62
    • 0027955697 scopus 로고
    • Absorption enhancement of intrapulmonary administered insulin by various absorption enhancers and protease inhibitors in rats
    • Yamamoto A, Umemori S, Muranishi S. Absorption enhancement of intrapulmonary administered insulin by various absorption enhancers and protease inhibitors in rats. J Pharm Pharmacol 1994; 46: 14-8
    • (1994) J. Pharm. Pharmacol. , vol.46 , pp. 14-18
    • Yamamoto, A.1    Umemori, S.2    Muranishi, S.3
  • 63
    • 0036025088 scopus 로고    scopus 로고
    • Technosphere/insulin: A new approach for effective delivery of human insulin via the pulmonary route
    • Pfutzner A, Mann AE, Steiner SS. Technosphere/insulin: a new approach for effective delivery of human insulin via the pulmonary route. Diabetes Technol Ther 2002; 4: 589-94
    • (2002) Diabetes Technol. Ther. , vol.4 , pp. 589-594
    • Pfutzner, A.1    Mann, A.E.2    Steiner, S.S.3
  • 64
    • 0041928149 scopus 로고    scopus 로고
    • Pilot study with Technosphere/PTH (1-34): A new approach for effective pulmonary delivery of parathyroid hormone (1-34)
    • Pfutzner A, Flacke F, Pohl R, et al. Pilot study with Technosphere/PTH (1-34): a new approach for effective pulmonary delivery of parathyroid hormone (1-34). Horm Metab Res 2003; 35: 319-23
    • (2003) Horm. Metab. Res. , vol.35 , pp. 319-323
    • Pfutzner, A.1    Flacke, F.2    Pohl, R.3
  • 65
    • 0029059091 scopus 로고
    • Aerosol deposition in the human lung following administration from a microprocessor-controlled pressurised metered dose inhaler
    • Farr SJ, Rowe AM, Rubsamen R, et al. Aerosol deposition in the human lung following administration from a microprocessor-controlled pressurised metered dose inhaler. Thorax 1995; 50: 639-44
    • (1995) Thorax , vol.50 , pp. 639-644
    • Farr, S.J.1    Rowe, A.M.2    Rubsamen, R.3
  • 66
    • 0036381765 scopus 로고    scopus 로고
    • Pulmonary insulin administration using the AERx insulin diabetes system
    • Thipphawong J, Otulana B, Clauson P, et al. Pulmonary insulin administration using the AERx insulin diabetes system. Diabetes Technol Ther 2002; 4: 499-504
    • (2002) Diabetes Technol. Ther. , vol.4 , pp. 499-504
    • Thipphawong, J.1    Otulana, B.2    Clauson, P.3
  • 67
    • 0017250017 scopus 로고
    • Development of an aerosol dosage form containing insulin
    • Lee SW, Sciarra JJ. Development of an aerosol dosage form containing insulin. J Pharm Sci 1976; 65: 567-73
    • (1976) J. Pharm. Sci. , vol.65 , pp. 567-573
    • Lee, S.W.1    Sciarra, J.J.2
  • 68
    • 4644372481 scopus 로고    scopus 로고
    • Evaluation of pressurised metered dose inhalers for pulmonary delivery of proteins and peptides
    • [abstract]
    • Oliver MJ, McKenzie L, Pritchard Y. Evaluation of pressurised metered dose inhalers for pulmonary delivery of proteins and peptides [abstract]. J Aerosol Med 2001; 14: 394
    • (2001) J. Aerosol Med. , vol.14 , pp. 394
    • Oliver, M.J.1    McKenzie, L.2    Pritchard, Y.3
  • 69
    • 0035814836 scopus 로고    scopus 로고
    • Inhaled human insulin treatment in patients with type 2 diabetes mellitus
    • Cefalu WT, Skyler JS, Kourides IA, et al. Inhaled human insulin treatment in patients with type 2 diabetes mellitus. Ann Intern Med 2001; 134: 203-7
    • (2001) Ann. Intern. Med. , vol.134 , pp. 203-207
    • Cefalu, W.T.1    Skyler, J.S.2    Kourides, I.A.3
  • 70
    • 0035798916 scopus 로고    scopus 로고
    • Efficacy of inhaled human insulin in type 1 diabetes mellitus: A randomized proof-of-concept study
    • Skyler JS, Cefalu WT, Kourides IA, et al. Efficacy of inhaled human insulin in type 1 diabetes mellitus: a randomized proof-of-concept study. Lancet 2001; 357: 331-5
    • (2001) Lancet , vol.357 , pp. 331-335
    • Skyler, J.S.1    Cefalu, W.T.2    Kourides, I.A.3
  • 71
    • 0036245372 scopus 로고    scopus 로고
    • Treatment satisfaction in type 2 diabetes: A comparison between an inhaled insulin regimen and a subcutaneous insulin regimen
    • Cappelleri JG, Cefalu WT, Rosenstock J, et al. Treatment satisfaction in type 2 diabetes: a comparison between an inhaled insulin regimen and a subcutaneous insulin regimen. Clin Ther 2002; 24: 552-64
    • (2002) Clin. Ther. , vol.24 , pp. 552-564
    • Cappelleri, J.G.1    Cefalu, W.T.2    Rosenstock, J.3
  • 72
    • 0043145587 scopus 로고    scopus 로고
    • Re-establishing gene therapy by aerosol using transfection-efficient, low toxicity DNA-polymer constructs
    • Dalby RN, Byron PR, Peart J, et al, editors. Raleigh (NC): Davis Horwood International Publishing
    • Densmore CL, Gautam A, Waldrep JC, et al. Re-establishing gene therapy by aerosol using transfection-efficient, low toxicity DNA-polymer constructs. In: Dalby RN, Byron PR, Peart J, et al, editors. Respiratory drug delivery VIII. Raleigh (NC): Davis Horwood International Publishing, 2002: 25-32
    • (2002) Respiratory Drug Delivery VIII , pp. 25-32
    • Densmore, C.L.1    Gautam, A.2    Waldrep, J.C.3
  • 73
    • 0035807445 scopus 로고    scopus 로고
    • An assessment of jet and ultrasonic nebulisers for the delivery of lactate dehydrogenase solutions
    • Khatri L, Taylor KM, Craig DQ, et al. An assessment of jet and ultrasonic nebulisers for the delivery of lactate dehydrogenase solutions. Int J Pharm 2001; 227: 121-31
    • (2001) Int. J. Pharm. , vol.227 , pp. 121-131
    • Khatri, L.1    Taylor, K.M.2    Craig, D.Q.3
  • 74
    • 0036935355 scopus 로고    scopus 로고
    • A widely available method for the assessment of aerosol delivery in cystic fibrosis
    • Kastelik JA, Wright GA, Aziz I, et al. A widely available method for the assessment of aerosol delivery in cystic fibrosis. Pulm Pharmacol Ther 2002; 15: 513-9
    • (2002) Pulm. Pharmacol. Ther. , vol.15 , pp. 513-519
    • Kastelik, J.A.1    Wright, G.A.2    Aziz, I.3
  • 75
  • 76
    • 4644226002 scopus 로고    scopus 로고
    • Development of the interferon gamma-1b (IFN-γ 1b)-AERx system
    • [abstract]
    • Mudumba S, Wu H, Ta S, et al. Development of the interferon gamma-1b (IFN-γ 1b)-AERx system [abstract]. J Aerosol Med 2003; 16: 189
    • (2003) J. Aerosol Med. , vol.16 , pp. 189
    • Mudumba, S.1    Wu, H.2    Ta, S.3
  • 77
    • 0034891605 scopus 로고    scopus 로고
    • Aerosolized protein delivery in asthma: Gamma camera analysis of regional deposition and perfusion
    • Sangwan S, Agosti JM, Bauer LA, et al. Aerosolized protein delivery in asthma: gamma camera analysis of regional deposition and perfusion. J Aerosol Med 2001; 14: 185-95
    • (2001) J. Aerosol Med. , vol.14 , pp. 185-195
    • Sangwan, S.1    Agosti, J.M.2    Bauer, L.A.3
  • 78
    • 0038132084 scopus 로고    scopus 로고
    • Bolus inhalation of rhDNase with the AERx system in subjects with cystic fibrosis
    • Geller D, Thipphawong J, Otulana B, et al. Bolus inhalation of rhDNase with the AERx system in subjects with cystic fibrosis. J Aerosol Med 2003; 16: 175-82
    • (2003) J. Aerosol Med. , vol.16 , pp. 175-182
    • Geller, D.1    Thipphawong, J.2    Otulana, B.3
  • 79
    • 0141562799 scopus 로고    scopus 로고
    • Absorption and metabolic effect of inhaled insulin: Intrapatient variability after inhalation via the Aerodose insulin inhaler in patients with type 2 diabetes
    • Perera AD, Kapitza C, Nosek L, et al. Absorption and metabolic effect of inhaled insulin: intrapatient variability after inhalation via the Aerodose insulin inhaler in patients with type 2 diabetes. Diabetes Care 2002; 12: 2276-81
    • (2002) Diabetes Care , vol.12 , pp. 2276-2281
    • Perera, A.D.1    Kapitza, C.2    Nosek, L.3
  • 80
    • 4644357463 scopus 로고    scopus 로고
    • TouchSpray technology: A preliminary in vitro evaluation of plasmid DNA of different size and topology
    • Dalby RN, Byron PR, Peart J, et al., editors. Raleigh (NC): Davis Horwood International Publishing
    • Smart J, Stangl R, Fritz E. TouchSpray technology: a preliminary in vitro evaluation of plasmid DNA of different size and topology. In: Dalby RN, Byron PR, Peart J, et al., editors. Respiratory drug delivery VIII. Raleigh (NC): Davis Horwood International Publishing, 2002: 529-31
    • (2002) Respiratory Drug Delivery VIII , pp. 529-531
    • Smart, J.1    Stangl, R.2    Fritz, E.3
  • 81
    • 0036367565 scopus 로고    scopus 로고
    • Aerosolization of protein solutions using thermal inkjet technology
    • Goodall S, Chew N, Chan K, et al. Aerosolization of protein solutions using thermal inkjet technology. J Aerosol Med 2002; 15: 351-7
    • (2002) J. Aerosol Med. , vol.15 , pp. 351-357
    • Goodall, S.1    Chew, N.2    Chan, K.3
  • 83
    • 0036373350 scopus 로고    scopus 로고
    • The role of particle properties in pharmaceutical powder inhalation formulations
    • Chew NY, Chan HK. The role of particle properties in pharmaceutical powder inhalation formulations. J Aerosol Med 2002; 15: 325-30
    • (2002) J. Aerosol Med. , vol.15 , pp. 325-330
    • Chew, N.Y.1    Chan, H.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.