Retrospective review of tizanidine (zanaflex®) overdose

Journal of Toxicology - Clinical Toxicology

Volumn 42, Issue 5, 2004, Pages 593-596

  Spiller, Henry A ^a   Bosse, George M ^a,b   Adamson, Larry A ^c  

^a KENTUCKY REGIONAL POISON CENTER   (United States)

^b University of Louisville School of Medicine   (United States)

^c UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Muscle relaxant; Overdose; Poisoning; Tizanidine

Indexed keywords

CLONIDINE; HYPERTENSIVE FACTOR; MUSCLE RELAXANT AGENT; NALOXONE; TIZANIDINE;

ADOLESCENT; ADULT; AGED; AGITATION; AROUSAL; BRADYCARDIA; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; COMA; CONFUSION; DOSE RESPONSE; DRUG MECHANISM; DRUG OVERDOSE; DRUG STRUCTURE; FEMALE; HEALTH CARE FACILITY; HOSPITALIZATION; HUMAN; HYPOTENSION; INTUBATION; LETHARGY; MALE; MEDICAL DOCUMENTATION; MENTAL DISEASE; MENTAL HEALTH; OUTCOMES RESEARCH; PALLIATIVE THERAPY; POISON CENTER; RETROSPECTIVE STUDY; REVIEW; TABLET; VOMITING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIDOTES; CHARCOAL; CHILD; CHILD, PRESCHOOL; CLONIDINE; FEMALE; HUMANS; INFANT; KENTUCKY; MALE; MIDDLE AGED; MUSCLE RELAXANTS, CENTRAL; OVERDOSE; POISON CONTROL CENTERS; RESPIRATION, ARTIFICIAL; RETROSPECTIVE STUDIES;

EID: 4644229614     PISSN: 07313810     EISSN: None     Source Type: Journal    
DOI: 10.1081/CLT-200026978     Document Type: Review

References (10)

1. Luciani A, Brugioni L, Serra L, Graziina A. Sinoatrial and atrio-ventricular node dysfunction in a case of tizanidine overdose. Vet Hum Toxicol 1995; 37:556-557.
2. Chu J, Nelson LS, Hoffman RS. Hypotesion in an unintentional overdose with tizanidine. J Toxicol Clin Toxicol 2001; 39:283 Abstract.
3. Goldfrank L, et al. Goldfrank's Toxicologic Emergencies. 7th ed. McGraw-Hill: New York, 2002; inside front cover.
4. Coward DM. Tizanidine: neuropharmacology and mechanism of action. Neurology 1994; 44(11 suppl. 9):S6-S10.
5. Product Information. Zanaflex®. Athena Neurosciences: San Francisco, CA, 1999.
6. Muramtsu I, Kigoshi S. Tizanidine may discriminaate between imodazoline-receptors and alpha 2-adrenoreceptors. Jpn J Pharmacol 1992; 59:457-459.
7. Klein-Schwartz W. Trends and toxic effects from pediatric clonidine exposures. Arch Pediatr Adloesc Med 2002; 156:392-396.
8. Conner CS, Watanabe AS. Clonidine overdose: a review. Am J Hosp Pharm 1979; 36:906-911.
9. Miettinen TJ, Kanto JH, Salonen MA, Scheinin M. The sedative and sympatholytic effects of oral tizanidine in healthy voluteers. Anesth Analg 1996; 82:817-820.
10. Wiley JF, Wiley CC, Torrey SB, Henretig FM. Clonidine poisoning in young children. J Pediatr 1990; 116:654-658.