Localization of the NO-cGMP signaling pathway molecules, NOS III-phosphorylation sites, ERK1/2 and Akt/PKB in osteoclasts

Journal of Periodontology

Volumn 75, Issue 8, 2004, Pages 1119-1125

  Korkmaz, Yüksel ^a   Baumann, Michael A ^b   Schröder, Hannsjörg ^b   Behrends, Sönke ^c   Addicks, Klaus ^b   Raab, Wolfgang H M ^a   Bloch, Wilhelm ^b,d  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

^d GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

Animal studies; Guanylase cyclose; Nitric acid; Nitric oxide synthase; Osteoclasts; Phosphorylation

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME ANTIBODY; GUANYLATE CYCLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SERINE; THREONINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BONE DEMINERALIZATION; CELL ACTIVATION; CELL FUNCTION; CELL SUBPOPULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; FROZEN SECTION; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERMETHOD COMPARISON; MALE; MOLAR TOOTH; NONHUMAN; OSTEOCLAST; PERFUSION; PERIODONTIUM; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STAINING; TISSUE FIXATION; TISSUE SECTION;

ALVEOLAR PROCESS; ANIMALS; CYCLIC GMP; GUANYLATE CYCLASE; IMMUNOENZYME TECHNIQUES; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OSTEOCLASTS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; SECOND MESSENGER SYSTEMS;

EID: 4644227876     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2004.75.8.1119     Document Type: Article

References (26)

1. Teitelbaum SL. Bone resorption by osteoclasts. Science 2000;289:1504-1508.
2. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and veins is nitric oxide. Proc Natl Acad Sci (USA) 1987;84:9265-9269.
3. Van't RJ, Ralston S. Nitric oxide and bone. Immunology 2001;103:255-261.
4. Evans DM, Ralston SH. Nitric oxide and bone. J Bone Min Res 1996;11:300-305.
5. Griffith OW, Stuehr D. Nitric oxide synthases: Properties and catalytic mechanism. Annu Rev Physiol 1995; 57:707-736.
6. Nathan C, Xie Q-W. Nitric oxide synthases: Roles, tools and controls. Cell 1994;78:915-918.
7. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase by Akt-dependent phosphorylation. Nature 1999;399:601-605.
8. Bernier SG, Haldar S, Michel T. Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase. J Biol Chem 2000;275:30707-30715.
9. 2+/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res 2001;88:E68-E75.
10. Ignarro LJ. Heme-dependent activation of guanylate cyclase by nitric oxide: A novel signal transduction mechanism. Blood Vessels 1991;28:67-73.
11. Murad F. Regulation of cytosolic guanylyl cyclase by nitric oxide: The NO-cyclic GMP signal transduction system. Adv Pharmacol 1994;26:19-33.
12. Denninger JW, Marietta MA. Guanylate cyclase and the NO/cGMP signaling pathway. Biochim Biophys Acta 1999;1411:334-350.
13. Russwurm M, Behrends S, Harteneck C, Koesling D. Functional properties of a naturally occurring isoform of soluble guanylyl cyclase. Biochem J 1998;335:125-130.
14. Behrends S, Harteneck C, Schultz G, Koesling D. A variant of soluble guanylyl cyclase contains an insert homologous to adenylyl cyclase and functions as a dominant negative protein. J Biol Chem 1995;270: 21109-21113.
15. Inoue A, Hiruma Y, Hirose S, et al. Stimulation by C-type natriuretic peptide of the differentiation of clonal osteoblastic MC3T3-E1 cells. Biochem Biophys Res Commun 1996;221:703-707.
16. Hagiwara H, Inoue A, Yamaguchi A, et al. cGMP produced in response to ANP and CNP regulates proliferation and differentiation of osteoblastic cells. Am J Physiol 1996;270: C1311-C1318.
17. Inoue A, Hiruma Y, Hirose S, Yamagucchi A, Hagiwara A. Reciprocal regulation by cyclic nucleotides of the differentiation of rat osteoblast-like cells and mineralization of nodules. Biochem Biophs Res Commun 1995;215: 1104-1110.
18. Behrends S, Kempfert J, Mietens A, Koglin M, Scholz H, Middendorff R. Developmental changes of nitric oxide-sensitive guanylyl cyclase expression in pulmonary arteries. Biochem Biophys Res Commun 2001;283:883-887.
19. 2 subunit. J Clin Endocrinol Metab 2001;86:909-912.
20. Brandi ML, Hukkanen M, Umeda T, et al. Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms. Proc Natl Acad Sci (USA) 1995;92:2954-2958.
21. MacIntyre I, Zaidi M, Towhidul AASM, et al. Osteoclast inhibition: An action of nitric oxide not mediated by cyclic GMP. Proc Natl Acad Sci (USA) 1991;88:2936-2940.
22. Kasten TP, Collin-Osdoby P, Patel N, et al. Potentiation of osteoclastic bone resorbing activity by inhibition of nitric oxide synthase. Proc Natl Acad Sci (USA) 1994;91: 3569-3573.
23. Mancini L, Moradi-Bidhendi N, Brandi ML, MacIntyre I. Nitric oxide superoxide and peroxynitrite modulate osteoclast activity. Biochem Biophys Res Commun 1998;243: 785-790.
24. Dong SS, Williams JP, Jordan SE, Cornwell T, Blair HC. Nitric oxide regulation of cGMP production in osteoclasts. J Cell Biochem 1999;73:478-487.
25. Holliday LS, Dean AD, Lin RH, Greenwald JE, Gluck SL. Low NO concentrations inhibit osteoclast formation in mouse marrow cultures by cGMP-dependent mechanism. Am J Physiol 1997;272:F283-F291.
26. Storey E. The nature of tooth movement. Am J Orthod 1973;63:292-314.