P2Y 2-receptor-mediated activation of a contralateral, lanthanide-sensitive calcium entry pathway in the human airway epithelium

British Journal of Pharmacology

Volumn 143, Issue 1, 2004, Pages 91-98

  Bahra, Parmjit ^a   Mesher, Jonathan ^a,b   Su, Li ^a   Poll, Christopher T ^a   Danahay, Henry ^a  

^a Novartis Institutes for Biomedical Research   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Airway epithelium; Cation channel; Econazole; Gd 3+; Mucociliary clearance; Receptor mediated calcium entry; Signal transduction; SKF96365

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; CALCIUM ION; ECONAZOLE; FURA 2; GADOLINIUM; LANTHANIDE; NICKEL; PURINE P2Y2 RECEPTOR; RUTHENIUM RED; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE; VERAPAMIL; 1 (2 (3 (4 METHOXYPHENYL)PROPOXY) 4 METHOXYPHENYLETHYL) 1H IMIDAZOLE; 1-(2-(3-(4-METHOXYPHENYL)PROPOXY)-4-METHOXYPHENYLETHYL)-1H-IMIDAZOLE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL STIMULATING AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FLUORESCENT DYE; IMIDAZOLE DERIVATIVE; PURINE P2 RECEPTOR;

ARTICLE; BASOLATERAL MEMBRANE; BRONCHUS MUCOSA; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONTROLLED STUDY; EPITHELIUM CELL; FLUORESCENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; AREA UNDER THE CURVE; CALCIUM SIGNALING; CELL CULTURE; DOSE RESPONSE; DRUG EFFECT; METABOLISM; RESPIRATORY TRACT MUCOSA;

AREA UNDER CURVE; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM SIGNALING; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FLUORESCENT DYES; FURA-2; IMIDAZOLES; INDICATORS AND REAGENTS; LANTHANOID SERIES ELEMENTS; RECEPTORS, PURINERGIC P2; RESPIRATORY MUCOSA; URIDINE TRIPHOSPHATE;

EID: 4644225254     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705913     Document Type: Article

References (33)

1. ATHERTON, H.C., JONES, G. & DANAHAY, H. (2003). IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am. J. Physiol. Lung Cell Mol. Physiol., 285, L730-L739.
2. BARNARD, E.A., BURNSTOCK, G. & WEBB, T.E. (1994). G protein coupled receptors for ATP and other nucleotides: a new receptor family. Trends Pharmacol. Sci., 8, 280-281.
3. 2+ signalling requirements. Biochem. J., 337, 153-169.
4. BERTRAND, C.A., DANAHAY, H., POLL, C.T., LABOISSE, C., HOPFER, U. & BRIDGES, R.J. (2004). Niflumic acid inhibits ATP-stimulated exocytosis in a mucin-secreting epithelial cell line. Am. J. Physiol. Cell Physiol., 286, 247-255.
5. 2+ redistribution. Cell Calcium, 30, 361-371.
6. 2+ entry mechanism in rat A7r5 smooth muscle cells stimulated with low concentrations of vasopressin. J. Physiol., 517, 121-134.
7. CLAPHAM, D.E. (1995). Calcium signaling. Cell, 80, 259-268.
8. 2+ influx. Two independently regulated mechanisms of influx stimulation coexist in neurosecretory PC12 cells. J. Biol. Chem., 267, 2164-2172.
9. COMMUNI, D., PAINDAVOINE, P., PLACE, G.A., PARMENTIER, M. & BOEYNAEMS, J.M. (1999). Expression of P2Y receptors in cell lines derived from the human lung. Br. J. Pharmacol., 127, 562-568.
10. CONWAY, J.D, BARTOLOTTA, T., ABDULLAH, L.H. & DAVIS, C.W. (2003). Regulation of mucin secretion from human bronchial epithelial cells grown in murine hosted xenografts. Am. J. Physiol. Lung Cell Mol. Physiol., 284, 945-954.
11. DANAHAY, H., ATHERTON, H., JONES, G., BRIDGES, R.J. & POLL, C.T. (2002). Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol., 282, L226-L236.
12. DAVIS, C.W., DOWELL, M.L., LETHEM, M. & VAN SCOTT, M. (1992). Goblet cell degranulation in isolated canine tracheal epithelium: response to exogenous ATP, ADP, and adenosine. Am. J. Physiol., 262, 1313-1323.
13. + absorption in wild-type and DeltaF508 CFTR-expressing human bronchial epithelia. Am. J. Physiol., 276, 827-837.
14. DONALDSON, S.H., LAZAROWSKI, E.R., PICHER, M., KNOWLES, M.R., STUTTS, M.J. & BOUCHER, R.C. (2000). Basal nucleotide levels, release, and metabolism in normal and cystic fibrosis airways. Mol. Meth., 6, 969-982.
15. 2+ entry is exaggerated in fresh preglomerular vascular smooth muscle cells of SHR. Kidney Int., 61, 2132-2141.
16. GLOSSMANN, H. & STRIESSNIG, J. (1990). Molecular properties of calcium channels. Rev. Physiol. Biochem. Pharmacol., 114, 1-105.
17. HALLER, T., ORTMAYR, J., FRIEDRICH, F., VOLKL, H. & DIETL, P. (1998). Dynamics of surfactant release in alveolar type II cells. Proc. Natl. Acad. Sci. U.S.A., 95, 1579-1584.
18. + channel in human airway Calu-3 cells. Am. J. Respir. Cell Mol. Biol., [Epub ahead of print].
19. KELLERMAN, D.J. (2002). P2Y(2) receptor agonists: a new class of medication targeted at improved mucociliary clearance. Chest, 121, 201-205.
20. 2+-entry in polarized human bronchial and colonic epithelial cells. Cell Calcium, 26, 253-260.
21. 2+ and cAMP. Am. J. Physiol., 263, 232-242.
22. LAZAROWSKI, E.R., BOUCHER, R.C. & HARDEN, T.K. (2000). Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations. J. Biol. Chem., 275, 31061-31068.
23. 2+ influx channels in leukocytes: a therapeutic target? Trends Pharmacol. Sci., 23, 63-70.
24. 2+ release. J. Biochem., 122, 498-505.
25. 2+ channel ECaCl. Br. J. Pharmacol., 134, 453-462.
26. 2+ release and influx in polarized epithelia. Nature, 377, 643-646.
27. 2+ transport and beyond. J. Physiol., 551, 729-740.
28. PETERSEN, O.H., BURDAKOV, D. & TEPIKIN, A.V. (1999). Polarity in intracellular calcium signaling. Bioessays, 21, 851-860.
29. PUTNEY JR, J.W. & MCKAY, R.R. (1999). Capacitative calcium entry channels. Bioessays, 21, 38-46.
30. - secretion in normal and cystic fibrosis human airway epithelia. In: Cilia and Mucus: From Development to Respiratory Defense, ed. Salathe M. pp. 303-314.
31. RIBEIRO, C.M., PARADISO, A.M., LIVRAGHI, A. & BOUCHER, R.C. (2003). The mitochondrial barriers segregate agonist-induced calcium-dependent functions in human airway epithelia. J. Gen. Physiol., 122, 377-387.
32. TOMINAGA, M., CATERINA, M.J., MALMBERG, A.B., ROSEN, T.A., GILBERT, H., SKINNER, K., RAUMANN, B.E., BASBAUM, A.I. & JULIUS, D. (1998). The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron, 21, 531-543.
33. ZSEMBERY, A., BOYCE, A.T., LIANG, L., PETI-PETERDI, J., BELL, P.D. & SCHWIEBERT, E.M. (2003). Sustained calcium entry through P2X nucleotide receptor channels in human airway epithelial cells. J. Biol. Chem., 278, 13398-13408.