Parameterizing matrix-assisted laser desorption/ionization: Effect of solvents and co-additives on analyte peak intensities

European Journal of Mass Spectrometry

Volumn 10, Issue 4, 2004, Pages 487-493

  Bashir, S ^a,b   Mutter, R ^a,c   Derrick, P J ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b TEXAS A AND M UNIVERSITY KINGSVILLE   (United States)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Absorbance; Co additives; Excited state; Gas phase; MALDI; MALDI ToF; Matrix; Matrix intermediate; Radicals; Solvents

Indexed keywords

5 METHOXYSALICYLIC ACID; BETA CYCLODEXTRIN; N,N DIMETHYLFORMAMIDE; SOLVENT; SUBSTANCE P; BETA CYCLODEXTRIN DERIVATIVE;

ABSORPTION; ARTICLE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR INTERACTION; CHEMISTRY; INSTRUMENTATION; MASS SPECTROMETRY; METHODOLOGY;

BETA-CYCLODEXTRINS; SOLVENTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTANCE P;

EID: 4644223527     PISSN: 14690667     EISSN: None     Source Type: Journal    
DOI: 10.1255/ejms.645     Document Type: Article

References (37)

1. S. Bashir, R. Mutter and P.J. Derrick, "Matrix-assisted laser desorption/ionization mass spectrometry with re-engineered 2,5-dihydroxybenzoic acid derivative", Analyst 128, 1452 (2003).
2. H.-J. Hsiu and J. Shiea, "Detection of Polystyrene Molecules with Molecular Weight up to 3.9 Million Daltons by MALDI Mass Spectrometry", J. Am. Soc. Mass Spectrom. 6S, 49S, WPC 127 (2000).
3. R.C. Beavis and B.T. Chait, "High-accuracy molecular mass determination of proteins using matrix-assisted laser desorption mass-spectrometry", Anal. Chem. 62, 1836 (1990).
4. F. Hillenkamp and M. Karas, "Mass-spectrometry of peptides and proteins by matrix-assisted ultraviolet-laser desorption ionization", Methods Enzymol. 193, 280 (1990).
5. M.C. Huberty, J.E. Vath, W. Yu and S.A. Martin, "Site-specific carbohydrate identification in recombinant proteins using MALD-TOF MS", Anal. Chem. 65, 2791 (1993).
6. K. Tang, S.L. Allman and C.H. Chen, "Mass-spectrometry of laser-desorbed oligonucleotides", Rapid Commun. Mass Spectrom. 6, 365 (1992).
7. B.S. Larsen, W.J. Simonsick Jr and C.N. McEwen, "The fundamentals of applying electrospray-ionization mass-spectrometry to low-mass poly(methyl methacrylate) polymers", J. Am. Soc. Mass Spectrom. 7, 287 (1996).
8. M.W.F. Nielen, "Maldi time-of-flight mass spectrometry of synthetic polymers", Mass Spectrom. Rev. 18, 309 (1999).
9. D.J. Harvey, "Matrix-assisted laser desorption/ionization mass spectrometry of carbohydrates", Mass Spectrom. Rev. 18, 349 (1999).
10. R. Zenobi and R. Knochenmuss, "Ion formation in MALDI mass spectrometry", Mass Spectrom. Rev. 17, 337 (1998).
11. H. Ehring, M. Karas and F. Hillenkamp, "Role of photoionization and photochemistry in ionization processes of organic-molecules and relevance for matrix-assisted laser desorption ionization mass-spectrometry", Org. Mass Spectrom. 27, 472 (1992).
12. R.C. Beavis T. Chaudhary and B.T. Chait, "alpha-cyano-4- hydroxycinnamic acid as a matrix for matrix-assisted laser desorption mass-spectrometry", Org. Mass Spectrom. 27, 156 (1992).
13. M.E. Gimon, L.M. Preston, T. Solouki, M.A. White and D.H. Russell, "Are proton-transfer reactions of excited-states involved in UV laser desorption ionization?", Org. Mass Spectrom. 27, 827 (1992).
14. K. Tanaka, H. Waki, Y. Ido, S. Akita, Y. Yoshida and T. Yoshida, "Protein and Polymer Analyses up to m/z 100 000 by Laser Ionization Time-of-Flight Mass Spectrometry", Rapid Commun. Mass Spectrom. 2, 151 (1988).
15. R.C. Beavis and B.T. Chait, "Matrix-assisted laser-desorption mass spectrometry using 355 nm radiation", Rapid Commun. Mass Spectrom. 3, 436 (1989).
16. K. Strupat, M. Karas and F. Hillenkamp, "2,5-dihydroxybenzoic acid - a new matrix for laser desorption ionization mass-spectrometry", Int. J. Mass Spectrom. Ion Processes. 111, 89 (1991).
17. M. Karas, H. Ehring, E. Nordhoff, B. Stahl, K. Strupat, F. Hillenkamp, M, Grehl and B. Krebs, "Matrix-assisted laser-desorption ionization mass-spectrometry with additives to 2,5-dihydroxybenzoic acid", Org. Mass Spectrom. 28, 1476 (1993).
18. (a) G. Micera, L.S. Erre, P. Piu, F. Cariati, G. Cariati and A. Sironi, "Interaction of metal-ions with humic-like models. 7. Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes of 2,5-dihydroxybenzoic acid", Inorg. Chim. A-Bioinorg. 107, 223 (1985);
19. (b) T. Glowiak, H. Kozlowski, L.S. Erre, G. Micera and B. Gulinati, "Crystal-structure of a polymeric complex of lead(II) with 2,6-dihydroxybenzoic acid", Inorg. Chim. Acta 202, 43 (1992).
20. G. Smith, M.C. Coyne and J.M. White, "Molecular co-crystals of aromatic carboxylic acids with 1,1-diethylurea: Synthesis and the crystal structures of a series of nitro-substituted analogues", Aust. J. Chem. 53, 203 (2000).
21. V. Karbach and R. Knochenmuss, "Do single matrix molecules generate primary ions in ultraviolet matrix-assisted laser desorption/ionization?", Rapid Commun. Mass Spectrom. 12, 968 (1998).
22. M. Wilming and K. Johnsson, "Spontaneous formation of the bioactive form of the tuberculosis drug isoniazid", Angew. Chem. Int. Ed. 38, 2588 (1999).
23. A. Vertes and R.D. Levine, "Sublimation versus fragmentation in matrix-assisted laser desorption", Chem. Phys. Lett. 171, 284 (1990).
24. T.J.D. Jorgensen, G. Bojesen and H. Rahbek-Nielsen, "The proton affinities of seven matrix-assisted laser desorption/ionization matrices correlated with the formation of multiply-charged ions", Eur. Mass Spectrom. 4, 39 (1998).
25. L.M. Preston-Schaffter, G.R. Kinsel and D.H. Russell, "Effects of heavy-atom substituents on matrices used for matrix-assisted laser-desorption ionization mass-spectrometry", J. Am. Soc. Mass Spectrom. 5, 800 (1994).
26. D. M. Price, S. Bashir and P.J. Derrick, "Sublimation properties of x,y-dihydroxybenzoic acid isomers as model matrix assisted laser desorption ionisation (MALDI) matrices", Thermochim. Acta 327, 167 (1999).
27. M. Mormann, S. Bashir, D. Kuck and P.J. Derrick, "Gas-phase basicities of the isomeric dihydroxybenzoic acids and gas-phase acidities of their radical cations", J. Am. Soc. Mass Spectrom. 11, 544 (2000).
28. R.J.J.M. Steenvoorden, K. Breuker and R. Zenobi, "The gas-phase basicities of matrix-assisted laser desorption/ionization matrices", Eur. Mass Spectrom. 3, 339 (1997).
29. H.C. Ludemann, F. Hillenkamp and R.W. Redmond, "Photoinduced hydrogen atom transfer in salicylic acid derivatives used as matrix-assisted laser desorption/ionization (MALDI) matrices", J. Phy. Chem. A 104, 3884 (2000).
30. B. Spengler, "Post-source decay analysis in matrix-assisted laser desorption/ionization mass spectrometry of biomolecules", J. Mass Spectrom. 32, 1019 (1997).
31. P.C. Liao and J. Allison, "Ionization processes in matrix-assisted laser-desorption ionization mass-spectrometry-matrix-dependent formation of [M + H](+) Vs [M + Na](+) ions of small peptides and some mechanistic comments", J. Mass Spectrom. 30, 408 (1995).
32. C.M. Land and G.R. Kinsel, "Investigation of the mechanism of intracluster proton transfer from sinapinic acid to biomolecular analytes", J. Am. Soc. Mass Spectrom. 9, 1060 (1998).
33. C.T.J. Scott, C. Kosmidis, W.J. Jia, W.D. Ledingham and R.P. Singhal, "Formation of atomic-hydrogen in matrix-assisted laser-desorption ionization", Rapid Commun. Mass Spectrom. 8, 829 (1994).
34. H. Ehring and B.U.R. Sundqvist, "Studies of the MALDI process by luminescence spectroscopy", J. Mass Spectrom. 30, 1303 (1995).
35. C.D. Mowry and M.V. Johnston, "Simultaneous detection of ions and neutrals produced by matrix-assisted laser-desorption", Rapid Commun. Mass Spectrom. 7, 569 (1993).
36. (a) R. Knochenmuss, V. Karbach, U. Wiesli, K. Breuker and R. Zenobi, "The matrix suppression effect in matrix-assisted laser desorption/ionization: Application to negative ions and further characteristics", Rapid Commun. Mass Spectrom. 12, 529 (1998);
37. (b) T.W.D Chan, A.W. Colburn, P.J. Derrick, D.J. Gardiner and M. Bowden, "Suppression of matrix ions in ultraviolet-laser desorption-scanning electron-microscopy and Raman-spectroscopy of the solid samples", Org. Mass Spectrom. 27, 188 (1992).