NS5A sequences of hepatitis C virus genotype 1 and interferon resistance: Where are we?

Journal of Infectious Diseases

Volumn 198, Issue 1, 2008, Pages 154-155

  Germanidis, Georgios ^a   Metallidis, Simeon ^b   Lazaraki, Georgia ^a,d   Pawlotsky, Jean Michel ^c   Nikolaidis, Paul ^b  

^a GHA 'Evangelismos'   (Greece)

^b AHEPA UNIVERSITY HOSPITAL   (Greece)

^c HENRI MONDOR HOSPITAL   (France)

^d NONE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN E2; JANUS KINASE; NONSTRUCTURAL PROTEIN 5A; PEGINTERFERON ALPHA; PROTEIN KINASE R; RIBAVIRIN;

AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; COMBINATION CHEMOTHERAPY; DRUG EFFICACY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNE RESPONSE; LETTER; MONOTHERAPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; TREATMENT FAILURE; VIRUS LOAD; VIRUS REPLICATION; VIRUS RESISTANCE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIVIRAL AGENTS; DRUG RESISTANCE, VIRAL; HEPACIVIRUS; HEPATITIS C; HUMANS; INTERFERON ALFA-2A; POLYETHYLENE GLYCOLS; SIGNAL TRANSDUCTION; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 46349102927     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/588709     Document Type: Letter

References (10)

1. Dal Pero F, Tang KH, Gerotto M, et al. Impact of NS5A sequences of hepatitis C virus genotype 1a on early viral kinetics during treatment with peginterferon-α2a plus ribavirin. J Infect Dis 2007; 196:998-1005.
2. Blindenbacher A, Duong FH, Hunziker L, et al. Expression of hepatitis C virus proteins inhibits interferon α signaling in the liver of transgenic mice. Gastroenterology 2003; 124:1465-75.
3. Polyak SJ, Paschal DM, McArdle S, Gale MJ Jr, Moradpour D, Gretch DR. Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication. Hepatology 1999;29:1262-71.
4. Gale MJ Jr, Korth MJ, Katze MG. Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance. Clin Diagn Virol 1998; 10:157-62.
5. Witherell GW, Beineke P. Statistical analysis of combined substitutions in nonstructural 5A region of hepatitis C virus and interferon response. J Med Virol 2001; 63:8-16.
6. Pawlotsky JM, Germanidis G, Neumann AU, Pellerin M, Frainais PO, Dhumeaux D. Interferon resistance of hepatitis C virus genotype 1b: relationship to nonstructural 5A gene quasispecies mutations. J Virol 1998; 72:2795-805.
7. François C, Duverlie G, Rebouillat D, et al. Expression of hepatitis C virus proteins interferes with the antiviral action of interferon independently of PKR-mediated control of protein synthesis. J Virol 2000; 74:5587-96.
8. Brillet R, Penin F, Hezode C, Chouteau P, Dhumeaux D, Pawlotsky JM. The nonstructural 5A protein of hepatitis C virus genotype 1b does not contain an interferon sensitivity-determining region. J Infect Dis 2007; 195:432-41.
9. Pilli M, Zerbini A, Penna A, et al. HCV-specific T-cell response in relation to viral kinetics and treatment outcome (DITTO-HCV project). Gastroenterology 2007; 133:1132-43.
10. Soler M, Pellerin M, Malnou CE, Dhumeaux D, Kean KM, Pawlotsky JM. Quasispecies heterogeneity and constraints on the evolution of the 5′ noncoding region of hepatitis C virus (HCV): relationship with HCV resistance to interferon-alpha therapy. Virology 2002; 298:160-73.