Stemucronatoside K, a novel C21 steroidal glycoside from Stephanotis mucronata, inhibited the cellular and humoral immune response in mice

International Immunopharmacology

Volumn 8, Issue 9, 2008, Pages 1231-1238

  Ye, Yiping ^a   Chen, Fengyang ^a   Sun, Hongxiang ^b   Li, Xiaoyu ^a   Xu, Shifang ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Antibody; Cytokine; Immunosuppressive; Proliferation; Stemucronatoside K; Stephanotis mucronata

Indexed keywords

ANTIBODY; CARBON; CONCANAVALIN A; CYCLOSPORIN A; CYTOKINE; GAMMA INTERFERON; GLYCOSIDE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2B ANTIBODY; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MITOGENIC AGENT; OVALBUMIN; PLANT EXTRACT; STEMUCRONATOSIDE K; STEPHANOTIS MUCRONATA EXTRACT;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CHINESE HERB; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG ISOLATION; DRUG STRUCTURE; FEMALE; HUMORAL IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; MEDICINAL PLANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SPECTROSCOPY; SPLEEN CELL; STEPHANOTIS MUCRONATA;

ANIMALS; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; APOCYNACEAE; CELL PROLIFERATION; FEMALE; IMMUNITY, CELLULAR; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; INDICATORS AND REAGENTS; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-4; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED ICR; MITOGENS; OVALBUMIN; PLANT ROOTS; SAPONINS; SPLEEN;

EID: 46349101711     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.04.014     Document Type: Article

References (25)

1. Ye Y.P., Li X.Y., Sun H.X., Chen F.Y., and Pan Y.J. Immunomodulating steroidal glycosides from the roots of Stephanotis mucronata. Helv Chim Acta 87 9 (2004) 2378-2384
2. Ye Y.P., Sun H.X., Li X.Y., Chen F.Y., Qin F., and Pan Y.J. Four new C-21 steroidal glycosides from the roots of Stephanotis mucronata and their immunological activities. Steroids 70 12 (2005) 791-797
3. Ye Y.P., Chen F.Y., Sun H.X., Li X.Y., and Pan Y.J. Two novel immunosuppressive pregnane glycosides from the roots of Stephanotis mucronata. Bioorg Med Chem Lett 16 (2006) 4586-4591
4. Li X.Y., Sun H.X., Ye Y.P., Chen F.Y., and Pan Y.J. C-21 steroidal glycosides from the roots of Cynanchum chekiangense and their immunosuppressive activities. Steroids 71 1 (2006) 61-66
5. 21 steroidal glycoside compounds from the roots of Stephanotis mucronata and their immunological activities. PhD Thesis. Zhejiang University, Zhejiang, China; 2006. p.86.
6. 3H-thymidin incorporation assay. Vet Immunol Immunophathol 70 (1999) 151-159
7. Zhu Y.N., Zhao W.M., and Yang Y.F. Periplocoside E, an effective compound from Periploca sepium Bge, inhibited T cell activation in vitro and vivo. J Pharmacol Exp Ther 316 (2006) 662-669
8. Yoshikawa K., Okada N., Kann Y., and Arihara S. Steroidal glycosides from the fresh stem of Stephanotis lutchuensis var. japonica (Asclepiadaceae). Chemical structures of stephanosides A---J. Chem Pharm Bull 44 (1996) 1790-1796
9. Waldmann H. The new immunosuppression. Curr Opin Chem Biol 7 (2003) 476-480
10. Wong S.H.Y. Therapeutic drug monitoring for immunosuppressants. Clin Chim Acta 313 (2003) 241-253
11. Kahan B.D., Keown P., Levy G.A., and Johnston A. Therapeutic drug monitoring of immunosuppressant drugs in clinical practice. Clin Ther 24 (2002) 330-350
12. Serkova N., Brand A., Christians U., and Leibfritz D. Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy. Biochim Biophys Acta 1314 (1996) 93-104
13. Rezaeipoor R., Saeidnia S., and Kamalinejad M. Immunosuppressive activity of Achillea talagonica on humoral immune responses in experimental animals. J Ethnopharmacol 65 (1999) 273-276
14. Rezaeipoor R., Saeidnia S., and Kamalinejad M. The effect of Plantago ovata on humoral immune responses in experimental animals. J Ethnopharmacol 72 (2000) 283-286
15. Mehrotra S., Mishra K.P., Maurya R., Srimal R.C., and Singh V.K. Immunomodulation by ethanolic extract of Boerhaavia diffusa roots. Int Immunopharmacol 2 (2002) 987-996
16. Mehrotra S., Mishra K.P., Maurya R., Srimal R.C., Yadav V.S., Pandey R., et al. Anticellular and immunosuppressive properties of ethanolic extract of Acorus calamus rhizome. Int Immunopharmacol 3 (2003) 53-61
17. Sun H.X., Qin F., and Pan Y.J. In vitro and in vivo immunosuppressive activity of Spica Prunellae ethanol extract on the immune responses in mice. J Ethnopharmacol 101 (2005) 31-36
18. Qin F., and Sun H.X. Immunosuppressive activity of Pollen Typhae ethanol extract on the immune responses in mice. J Ethnopharmacol 102 (2005) 424-429
19. Sun H.X., and Wang H. Immunosuppressive activity of the ethanol extract of Siegesbeckia orientalis on the immune responses to ovalbumin in mice. Chem Biodivers 3 (2006) 754-761
20. Soares M.B.P., Brustolim D., Santos L.A., Bellintani M.C., Paiva F.P., Ribeiro Y.M., et al. Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection. Int Immunopharmacol 6 (2006) 408-414
21. Marciani D.J., Press J.B., Reynolds R.C., Pathak A.K., Pathak V., Gundy L.E., et al. Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity. Vaccine 18 (2000) 3141-3151
22. Finkelman F.D., Holmes J., Katona I.M., Urban Jr. J.F., Beckmann M.P., Park L.S., et al. Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 8 (1990) 303-333
23. Coffman R.L., and von der Weid T. Multiple pathways for the initiation of T helper 2 (Th2) responses. J Exp Med 185 (1997) 373-375
24. Begley C.G., and Nicola N.A. Resolving conflicting signals: cross inhibition of cytokine signaling pathways. Blood 93 (1999) 1443-1447
25. Farrar J.D., Asnagli H., and Murphy K.M. T helper subset development: roles of instruction, selection, and transcription. J Clin Invest 109 (2002) 431-435