Genetic analysis of reelin gene (RELN) SNPs: No association with autism spectrum disorder in the Indian population

Neuroscience Letters

Volumn 441, Issue 1, 2008, Pages 56-60

  Dutta, Shruti ^a   Sinha, Swagata ^a   Ghosh, Saurabh ^b   Chatterjee, Anindita ^a   Ahmed, Shabina ^c   Usha, Rajamma ^a  

^a Manovikas Kendra Rehabilitation and Research Institute for the Handicapped   (India)

^b INDIAN STATISTICAL INSTITUTE   (India)

^c Assam Autism Foundation   (India)

Author keywords

Autism; Case control analysis; Family based analyses; Linkage disequilibrium; PDD NOS

Indexed keywords

REELIN;

ARTICLE; AUTISM; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GENE AMPLIFICATION; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; INDIAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCREENING; SINGLE NUCLEOTIDE POLYMORPHISM;

AUTISTIC DISORDER; CELL ADHESION MOLECULES, NEURONAL; DNA MUTATIONAL ANALYSIS; EXTRACELLULAR MATRIX PROTEINS; FAMILY HEALTH; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INDIA; LINKAGE DISEQUILIBRIUM; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; SERINE ENDOPEPTIDASES; TRINUCLEOTIDE REPEATS;

EID: 46349098939     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.06.022     Document Type: Article

References (33)

1. Ashley-Koch A.E., Jaworski J., Ma D.Q., Mei H., Ritchie M.D., Skaar D.A., Robert D.G., Worley G., Abramson R.K., Wright H.H., Cuccaro M.L., Gilbert J.R., Martin E.R., and Pericak-Vance M.A. Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk. Psychiatr. Genet. 17 (2007) 221-226
2. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), (DSM IV), American Psychiatric Association, Washington, DC
3. Bailey A., Le C.A., Gottesman I., Bolton P., Simonoff E., Yuzda E., and Rutter M. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol. Med. 25 (1995) 63-77
4. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
5. Bonora E., Beyer K.S., Lamb J.A., Parr J.R., Klauck S.M., Benner A., Paolucci M., Abbott A., Ragoussis I., Poustka A., Bailey A.J., and Monaco A.P. International molecular genetic study of autism (IMGSAC) analysis of reelin as a candidate gene for autism. Mol. Psych. 8 (2003) 885-892
6. Chakrabarti S., and Fombonne E. Pervasive developmental disorders in preschool children: confirmation of high prevalence. Am. J. Psychiatr. 162 (2005) 1133-1141
7. D'Arcangelo G., Miao G.G., Chen S.C., Soares H.D., Morgan J.I., and Curran T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature 374 (1995) 719-723
8. Devlin B., Bennett P., Dawson G., Figlewicz D.A., Grigorenko E.L., McMahon W., Minshew N., Pauls D., Smith M., Spence M.A., Rodier P.M., and Stodgell C. The CPEA genetics network, G.D. Schellenberg, Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 126B (2004) 46-50
9. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet. Epidemiol. 25 (2003) 115-121
10. Dutta S., Das S., Guhathakurta S., Sen B., Sinha S., Chatterjee A., Ghosh S., Ahmed S., Ghosh S., and Usha R. Glutamate receptor 6 gene (Glur6 or GRIK2) polymorphisms in the Indian population: a genetic association study on autism spectrum disorder. Cell Mol. Neurobiol. 27 (2007) 1035-1047
11. Dutta S., Guhathakurta S., Sinha S., Chatterjee A., Ahmed S., Ghosh S., Gangopadhyay P.K., Singh M., and Usha R. Reelin gene polymorphisms in Indian population: family-based evidence for association of 5'UTR CGG-repeat with autism. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 144 B (2007) 106-112
12. Fatemi S.H., Earle J.A., and McMenomy T. Reduction in reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol. Psychiatr. 57 (2000) 654-663
13. Fatemi S.H., Stary J.M., and Egan E.A. Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorder. Cell Mol. Neurobiol. 22 (2002) 139-152
14. Fatemi S.H., Stary J.M., Halt A.R., and Realmuto G.R. Dysregulation of reelin and bcl-2 proteins in autistic cerebellum. J. Autism Dev. Disord. 31 (2001) 529-535
15. Guhathakurta S., Ghosh S., Sinha S., Chatterjee A., Ahmed S., RoyChowdhury S., Gangopadhyay P.K., Singh M., and Usha R. Serotonin transporter promoter variants: analysis in Indian autistic and control population. Brain Res. 1092 (2006) 28-35
16. Hong S.E., Shugart Y.Y., Huang D.T., Shahwan S.A., Grant P.E., Hourihane J.O.B., Martin N.D.T., and Walsh C.A. Autosomal recessive lissencephaly with cerebellar hypoplasiais associated with human reelin mutations. Nat. Genet. 26 (2000) 93-96
17. Impagnatiello F., Guidotti A.R., Pesold C., Dwivedi Y., Caruncho H., and Pisu M.G. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 15718-15723
18. International Molecular Genetic Study of Autism Consortium (IMGSAC), Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q, Hum. Mol. Genet. 10 (2001) 973-982.
19. Krebs M.O., Betancur C., Leroy S., Bourdel M.C., Gillberg C., and Leboyer M. PARIS Study, Absence of association between a polymorphic GGC repeat in the 5' untranslated region of the reelin gene and autism. Mol. Psych. 7 (2002) 801-804
20. Li J., Nguyen L., Gleason C., Lotspeich L., Spiker D., Risch N., and Myers R.M. Lack of evidence for an association between WNT2 and RELN polymorphisms and autism. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 126B (2004) 51-57
21. A.M. Persico, L. D'Agruma, M. Maiorano, A. Totaro, R. Militerni, C. Bravaccio, T.H. Wassink for the CLSA, C. Schneider, R. Melmed, S. Trillo, F. Montecchi, M. Palermo, T. Pascucci, S. Puglisi-Allegra, K.L. Reichelt, M. Conciatori, R. Marino, C.C. Quattrocchi, A. Baldi, L. Zelante, P. Gasparini, F. Keller, Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder, Mol. Psychiatr. 6 (2001) 150-159.
22. Purcell S., Cherny S.S., and Sham P.C. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19 (2003) 149-150
23. Rice D.S., and Curran T. Role of the reelin signaling pathway in central nervous system development. Annu. Rev. Neurosci. 24 (2001) 1005-1039
24. Sambrook J., and Russell D.W. Isolation of High Molecular Weight DNA from Mammalian Cells using Proteinase K and Phenol. Molecular Cloning: A Laboratory Manual vol. 1 (2001), Cold Spring Laboratory Press, New York pp. 6.0-6.64
25. Schopler E., Reichler R.J., and Renner B.R. The Childhood Autism Rating Scale for Diagnostic Screening and Classification of Autism (1986), Irvington, New York
26. Serajee F.J., Zhong H., and Mahbubul H.A.H. Association of reelin gene polymorphisms with autism. Genomics 87 (2006) 75-83
27. Sham C.P., and Curtis D. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann. Hum. Genet. 59 (1995) 323-336
28. Sham P.C., and Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann. Hum. Genet. 59 (1995) 97-105
29. Skaar D.A., Shao Y., Haines J.L., Stenger J.E., Jaworski J., Martin E.R., Delong G.R., Moore J.H., McCauley J.L., Sutcliffe J.S., Ashley-Koch A.E., Cuccaro M.L., Folstein S.E., Gilbert J.R., and Pericak-Vance M.A. Analysis of the RELN gene as a genetic risk factor for autism. Mol. Psych. 10 (2005) 563-571
30. Terwilliger J.D., and Ott J. A haplotype-based 'Haplotype Relative Risk' approach to detecting allelic associations. Hum. Hered. 42 (1992) 337-346
31. Xu J., Zwaigenbaum L., Szatmari P., and Scherer S.W. Molecular cytogenetics of autism, invited reviews. Curr. Genomics 5 (2004) 347-364
32. Yeh F.C., and Boyle T.J.B. Population genetic analysis of co-dominant and dominant markers and quantitative traits. Belgian J. Bot. 129 (1997) 157
33. Zhang H., Liu X., Zhang C., Mundo E., Macciardi F., Grayson D.R., Guidotti A.R., and Holden J.J.A. Reelin gene alleles and susceptibility to autism spectrum disorders. Mol. Psychiatr. 7 (2002) 1012-1017