Effects of in vitro brevetoxin exposure on apoptosis and cellular metabolism in a leukemic T cell line (Jurkat)

Marine Drugs

Volumn 6, Issue 2, 2008, Pages 291-307

  Walsh, Catherine J ^a   Leggett, Stephanie R ^a   Strohbehn, Kathryn ^a   Pierce, Richard H ^b   Sleasman, John W ^c  

^a CENTER FOR SHARK RESEARCH   (United States)

^b MOTE MARINE LABORATORY   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Brevetoxin; Immunotoxicity; Karenia brevis; Red tide

Indexed keywords

1 (4,5 DIMETHYLTHIAZOL 2 YL) 3,5 DIPHENYLFORMAZAN; BREVETOXIN; CASPASE 3; FORMAZAN; TRYPAN BLUE;

APOPTOSIS; ARTICLE; CELL METABOLISM; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DINOFLAGELLATE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOTOXICITY; IN VITRO STUDY; KARENIA BREVIS; LEUKEMIA CELL LINE; RED TIDE;

ALGAE; DINOPHYCEAE; KARENIA BREVIS;

EID: 46349094954     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md6020291     Document Type: Article

References (55)

1. Van Dolah, F.M. Marine Algal Toxins: Origins, Health Effects, and Their Increased Occurrence. Environ. Health Perspect. 2000, 108, 133-141.
2. Knap, A.; Dwailly, E.; Furgal, C.; Galvin, J.; Baden, D.; Bowen, R.E.; Depledge, M.; Duguay, L.; Fleming, L.E.; Ford, T.; Moser, F.; Owen, R., Suk; W.A.; Unluata, U. Indicators of Ocean Health and Human Health: Developing a Research and Monitoring Framework. Environ. Health Perspect. 2002, 110, 839-845.
3. Sandifer, P.A.; Holland, A.F.; Rowles, T.K.; Scott, G.I. The Oceans and Human Health. Environ. Health Perspect. 2004, 112(8), A454-455.
4. Tyson, F.L.; Rice, D.L.; Dearry, A. Connecting the Oceans and Human Health. Environ. Health Perspect. 2004, 112(8), A455-A456.
5. Pierce, R.H.; Henry, M.S.; Blum, P.C. Brevetoxin Abundance and Composition during ECOHAB-Florida Field Monitoring Cruises in the Gulf of Mexico. Continent. Shelf Res. 2008, 28, 45-58.
6. Cheng, Y.S.; Zhou, Y.; Irvin, C.M.; Pierce, R.H.; Naar, J.; Backer, L.C.; Fleming, L.E.; Kirkpatrick, B.; Baden, D.G. Characterization of Marine Aerosol for Assessment of Human Exposure to Brevetoxins. Environ. Health Perspect. 2005, 113(5), 638-643.
7. Bourdelais, J.; Jacobs, H.M.; Wright, J.L.C.; Bigwarf, P.M.; Baden, D.G. A New Polyether Ladder Compound Produced by the Dinoflagellate, Karenia brevis. J. Nat. Prod. 2005, 68, 2-6.
8. Abraham, A.; Plakas, S.M.; Wang, Z.; Jester, E.L.; El Said, K.R.; Granade, H.R.; Henry, M.S.; Blum, P.C.; Pierce, R.H.; Dickey, R.W. Characterization of Polar Brevetoxin Derivatives Isolated from Karenia brevis Cultures and Natural Blooms. Toxicon 2006, 48(1), 104-115.
9. Backer, L.C.; Fleming, L.E.; Rowan, A.; Cheng Y.-S.; Benson, J.; Pierce, R.H.; Zaias, J.; Bean, J.; Bossart, G.D.; Johnson, D.; Quimbo, R.; Baden, D.G. Recreational Exposure to Aerosolized Brevetoxins during Florida Red Tide Events. Harmful Algae 2003, 2, 19-29.
10. Backer, L.C.; Kirkpatrick, B.; Fleming, L.E.; Cheng, Y.S.; Pierce, R.; Bean, J.A.; Clark, R.; Johnson, D.; Wanner, A.; Tamer, R.; Zhou, Y.; Baden, D.G. Occupational Exposure to Aerosolized Brevetoxins during Florida Red Tide Events: Effects on a Healthy Worker Population. Environ. Health Perspect. 2005, 113(5), 644-649.
11. Kirkpatrick, B.; Fleming, L.E.; Squicciarini, D.; Backer, L.C.; Clark, R.; Abraham, W.; Benson, J.; Cheng, Y.S.; Johnson, D.; Pierce, R.; Zaias, J.; Bossart, G.D.; Baden, D.G. Literature Review of Florida Red Tide: Implications for Human Health Effects. Harmful Algae 2004, 3(2), 99-115.
12. Fleming, L.E.; Backer, L.C.; Baden, D.G. Overview of Aerosolized Florida Red Tide Toxins: Exposures and Effects. Environ. Health Perspect. 2005, 113(5), 618-620.
13. Fleming, L.E.; Kirkpatrick, B.; Backer, L.C.; Bean, J.A.; Wanner, A.; Dalpra, D.; Tamer, R.; Zaias, J.; Cheng, Y.S.; Pierce, R.; Naar, J.; Abraham, W.; Clark, R.; Zhou, Y.; Henry, M.S.; Johnson, D.; Van de Bogart, G.; Bossart, G.D.; Harrington, M.; Baden, D.G. Initial Evaluation of the Effects of Aerosolized Florida Red Tide Toxins (Brevetoxins) in Persons with Asthma. Environ. Health Perspect. 2005, 113(5), 650-657.
14. Fleming, L.E.; Kirkpatrick, B.; Backer, L.C.; Bean, J.A.; Wanner, A.; Reich, A.; Zaias, J.; Cheng, Y.S.; Pierce, R.; Naar, J.; Abraham, W.M.; Baden, D.G. Aerosolized Red-Tide Toxins (Brevetoxins) and Asthma. Chest 2007, 131(1), 187-194.
15. Kirkpatrick, B.; Fleming, L.E.; Backer, L.C.; Bean, J.A.; Tamer, R.; Kirkpatrick, G.; Kane, T.; Wanner, A.; Dalpra, D.; Reich, A.; Baden, D.G. Environmental Exposures to Florida Red Tides: Effects on Emergency Room Respiratory Diagnoses Admissions. Harmful Algae 2006, 5, 526-33.
16. Bossart, G.D., Baden, D.G..; Ewing, R.; Roberts, B.; Wright, S. Brevetoxicosis in Manatees (Trichechus manatus latirostris) from the 1996 Epizootic: Gross, Histopathologic, and Immunocytochemical Features. Toxicol. Pathol. 1998, 26, 276-282.
17. Walsh, C.J.; Luer, C.A.; Noyes, D.R. Effects of Environmental Stressors on Lymphocyte Proliferation in Florida Manatees, Trichechus manatus latirostris. Vet. Immunol. Immunopathol. 2005, 103, 247-256.
18. Kreuder, C.; Mazet, J.A.K.; Bossart, G.D.; Carpenter, T.E., Holyoak, M.; Elie, M.S.; Wright, S.D. Clinicopathologic Features of Suspected Brevetoxicosis in Double-Crested Cormorants (Phalacrocorax auritus) Along the Florida Gulf Coast. J. Zoo Wildlife Med. 2002, 33, 8-15.
19. Benson, J.M.; Tischler, D.L.; Baden, D.G. Uptake, Tissue Distribution, and Excretion of Brevetoxin 3 Administered to Rats by Intratracheal Instillation. J. Toxicol. Environ. Health A 1999, 57, 345-355.
20. Benson, J.; Hahn, F.; March, T.; McDonald, J.; Sopori, M.; Seagrave, J.; Gomez, A.; Bourdelais, A.; Naar, J.; Zaias, J.; Bossart, G.; Baden, D. Inhalation Toxicity of Brevetoxin 3 in Rats Exposed for 5 Days. J. Toxicol. Environ. Health A 2004, 67(18), 1443-1456.
21. Benson, J.M.; Hahn, F.F.; March, T.H.; McDonald, J.D.; Gomez, A.P.; Sopori, M.J.; Bourdelais, A.J.; Naar, J.; Zaias, J.; Bossart, G.D.; Baden, D.G. Inhalation Toxicity of Brevetoxin 3 in Rats Exposed for Twenty-two Days. Environ. Health Perspect. 2005, 113, 626-631.
22. Sayer, A.; Hu, Q.; Bourdelais, A.J.; Baden, D.G., Gibson, J.E. The Effect of Brevetoxin-Induced DNA Damage in Human Lymphocytes. Genotoxicology 2005, 79, 683-688.
23. Han, T.K.; Derby, M.; Martin, D.F.; Wright, S.D.; Dao, M.L. Effects of Brevetoxins on Murine Myeloma SP2/O Cells. Aberrant Cellular Division. Int. J. Toxicol. 2002, 22, 73-80.
24. Sayer, A.; Hu, Q.; Bourdelais, A.J.; Baden, D.G.; Gibson, J.E. The Inhibition of CHO-K1-BH4 Cell Proliferation and Induction of Chromosomal Aberrations by Brevetoxins in vitro. Food Chem. Toxicol. 2006, 44, 1082-1092.
25. Abraham, R.T.; Weiss, A. Jurkat T cells and development of the T-cell receptor signaling paradigm. Nat. Rev. Immunol. 2004, 4, 301-308.
26. + channels in human leukemic Jurkat T cells. J. Biol. Chem. 2000, 275, 39954-39963.
27. + channel in Jurkat T-Lymphocyte. J. Pharmacol. Sci. 2007, 104, 94-98.
28. Eisenbrand, G.; Pool-Zobel, B.; Baker, V.; Balls, M.; Blaauboer, B.J.; Boobis, A.; Carere, A.; Kevekordes, S.; Pieters, R.; Kleiner, J. Methods of in vitro toxicology. Food Chem. Toxicol. 2002, 40, 193-206.
29. Radwan, F.F.; Wang, Z.; Ramsdell, J.S. Identification of a Rapid Detoxification Mechanism for Brevetoxin in Rats. Toxicol. Sci. 2005, 85(2), 839-846.
30. Woofter, R.; Dechraoui, M.Y.; Garthwaite, I.; Towers, N.R.; Gordon, C.J.; Córdova, J.; Ramsdell, J.S. Measurement of Brevetoxin Levels by Radioimmunoassay of Blood Collection Cards after Acute, Long-term, and Low Dose Exposure in Mice. Environ. Health Perspect. 2003, 111, 1595-1600.
31. Woofter, R.T.; Brendtro, K.; Ramsdell, J.S. Uptake and Elimination of Brevetoxin in Blood of Striped Mullet (Mugil cephalus) after Aqueous Exposure to Karenia brevis. Environ. Health Perspect. 2005, 11(1), 11-16.
32. Tibbetts, B.M.; Baden, D.G.; Benson, J.M.; Uptake, Tissue Distribution, and Excretion of Brevetoxin-3 Administered to Mice by Intratracheal Instillation. J. Toxicol. Environ. Health A 2006, 69(14), 1325-1335.
33. Woofter, R.T.; Spiess, P.C.; Ramsdell, J.S. Distribution of Brevetoxin (PbTx-3) in Mouse Plasma: Association with High-Density Lipoproteins. Environ. Health Perspect. 2005, 113(11), 1491-1496.
34. Woofter, R.T.; Ramsdell, J.S. Distribution of Brevetoxin to Lipoproteins in Human Plasma. Toxicon 2007, 49, 1010-1018.
35. Benson, J.M.; Gomez, A.P.; Statom, G.L.; Tibbetts, B.M.; Fleming, L.E.; Backer, L.C.; Reich, A.; Baden, D.G. Placental Transport of Brevetoxin-3 in CD-1 Mice. Toxicon 2006, 48, 1018-1026.
36. Katunuma, N.; Matsunaga, Y.; Himeno, K.; Hayashi, Y. Insights into the Roles of Cathepsin in Antigen Processing and Presentation Revealed by Specific Inhibitors. Biol. Chem. 2003, 384, 883-890.
37. Sudarsanam, S.; Virca, G.D.; March, C.J.; Srinivasan, S. An Approach to Computer-Aided Inhibitory Design: Application to Cathepsin L. J. Comput Aided Mol. Des. 1992, 6(3), 223-233.
38. Goyarts, T.; Dänicke, S.; Tiemann, U.; Rothkötter, H.J. Effect of the Fusarium Toxin Deoxynivalenol (DON) on IgA, IgM, and IgG Concentrations and Proliferation of Porcine Blood Lymphocytes. Toxicol. In vitro 2006, 20(6), 858-867.
39. Minervini, F.; Giannoccaro, A.; Cavallini, A.; Visconti, A. Investigations on Cellular Proliferation Induced by Zearalenone and Its Derivatives in Relation to the Estrogenic Parameters. Toxicol. Lett. 2005, 159(3), 272-283.
40. Khan, K.N.; Masuzaki, H.; Fujishita, A.; Kitajima; M.; Kohno, T.; Sekine, I.; Matsuyama, T.; Ishimaru, T. Regulation of Hepatocyte Growth Factor by Basal and Stimulated Macrophages in Women with Endometriosis. Human Reprod. 2005, 20, 2004-2013.
41. Abraham, W.M.; Bourdelais, A.J.; Sabater, J.R.; Ahmed, A.; Lee, T.A.; Serebriakov, I.; Baden, D.G. Airway Responses to Aerosolized Brevetoxin in an Animal Model of Asthma. Am. J. Respir. Crit. Care Med. 2005, 171, 26-34.
42. Jeglitsch, G.; Rein, K.; Baden, D.G.; Adams, D.J. Brevetoxin-3 (PbTx-3) and its Derivatives Modulate Single Tetrodotoxin-Sensitive Sodium Channels in Rat Sensory Neurons. J. Pharmacol. Exptl. Therap. 1998, 284(2), 516-525.
43. Purkerson, S.L.; Baden, D.G.; Fieber, L.A. Brevetoxin Modulates Neuronal Sodium Channels in Two Cell Lines Derived from Rat Brain. Neurotoxicology 1999, 20(6), 909-920.
44. Baden, D.G.; Bourdelais, A.J.; Jacocks, H.; Michelliza, S.; Naar, J. Natural and Derivative Brevetoxins: Historical Background, Multiplicity, and Effects. Environ. Health Perspect. 2005, 113(5), 621-625.
45. Washburn, B.S.; Rein, K.S.; Baden, D.G.; Walsh, P.J.; Hinton, D.E.; Tullis, K.; Denison, M.S. Brevetoxin-6 (PbTx-6), a Nonaromatic Marine Neurotoxin, is a Ligand of the Aryl Hydrocarbon Receptor. Arch. Biochem. Biophys. 1997, 343(2), 149-156.
46. Radwan, F.F.; Ramsdell, J.S. Characterization of In vitro Oxidative and Conjugative Metabolic Pathways for Brevetoxin (PbTx-2). Toxicol. Sci. 2006, 89(1), 57-65.
47. Washburn, B.S.; Baden, D.G.; Gassman, N.J.; Walsh, P.J. Brevetoxin: Tissue Distribution and Effect on Cytochrome P450 Enzymes in Fish. Toxicon 1994, 32(7), 799-805.
48. Dey, A.; Dhawan, A.; Kishore Seth, P.; Parma, D. Evidence for Cytochrome P450 2E1 Catalytic Activity and Expression in Rat Blood Lymphocytes. Life Sci. 2005, 77, 1082-1093.
49. Haas, C.E.; Brazeau, D.; Cloen, D.; Booker, B.M.; Frerichs, V.; Zaranek, C.; Frye, R.F.; Kufel, T. Cytochrome P450 mRNA Expression in Peripheral Blood Lymphocytes as a Predictor of Enzyme Induction. Eur. J. Clin. Parmacol. 2005, 61, 583-593.
50. Van Duursen, M.B.M.; Sanderson, J.T.; Van den Berg, M. Cytochrome P450 1A1 and 1B1 in Human Blood Lymphocytes are Not Suitable as Biomarkers of Exposure to Dioxin-Like Compounds: Polymorphisms and Interindividual Variation in Expression and Inducibility. Toxicol. Sci. 2005, 85, 703-712.
51. Pierce, R.H.; Henry, M.S.; Blum, P.C.; Hamel, S.L.; Kirkpatrick, B.; Cheng, Y.S., Zhou, Y.; Irvin, C.M.; Naar, J.; Weidner, A.; Fleming, L.E.; Backer, L.C.; Baden, D.G. Brevetoxin Composition in Water and Marine Aerosol Along a Florida Beach: Assessing Potential Human Exposure to Marine Biotoxins. Harmful Algae 2005, 4, 965-972.
52. Baur, H.; Kaspare, S.; Pfaff, E. Criteria of Viability of Isolated Liver Cells. Hoppe-Seylers Z. Physiol. Chem. 1975, 356, 827-838.
53. Mosmann, T.J. Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays. J. Immunol. Meth. 1983, 65, 55-63.
54. Sugawara, J.; Fukaya, T.; Murakami, T.; Yoshida, H.; Yajima, A. Hepatocyte Growth Factor Stimulates Proliferation, Migration, and Lumen Formation of Human Endometrial Epithelial Cells in vitro. Biol. Reprod. 1997, 57, 936-942.
55. Nicholson, D.W.; Ali, A.; Thornberry, N.A.; Vaillancourt, J.P., Ding, C.K.; Gallant, M.; Gareau, Y.; Griffin, P.R.; Labelle, M.; Lazebnik, Y.A., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995, 376(6535), 37-43.