Isolation and characterization of degradation products of citalopram and process-related impurities using RP-HPLC

Journal of Separation Science

Volumn 31, Issue 10, 2008, Pages 1729-1738

  Rao, Ramisetti Nageswara ^a   Raju, Ale Narasa ^a   Narsimha, Ramaram ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Antidepressant; ESI MS MS; Forced degradation; Isolation and characterization; Process related impurities

Indexed keywords

CHEMOTHERAPY; DEGRADATION; DRUG DELIVERY; DRUG DOSAGE; DRUG PRODUCTS; FLUIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERS; LIQUID CHROMATOGRAPHY; LIQUID PHASE EPITAXY; PHASE SEPARATION; SEPARATION; SIZE SEPARATION; SULFATE MINERALS;

(E ,3E) PROCESS; (I ,J) CONDITIONS; BUFFER CONCENTRATIONS; BULK DRUGS; CITALOPRAM; DEGRADATION PRODUCTS; DIETHYLAMINE (DEA); DIFFERENT SOLVENTS; DRUG MANUFACTURING; ELUENTS; ESI MS MS; GRADIENT ELUTION MODE; HYDROBROMIDE; ISOLATION AND CHARACTERIZATION; LIQUID CHROMATOGRAPHIC METHOD; MOBILE PHASE; PHARMACEUTICAL FORMULATIONS; PHOTODIODE ARRAY DETECTOR (PDA); RELATED SUBSTANCES; REVERSED PHASE (RP); RP-HPLC; SIMULTANEOUS SEPARATION; VARIABLE CONDITIONS;

QUALITY CONTROL;

ACETONITRILE; CITALOPRAM; DIETHYLAMINE; METHANOL; SOLVENT;

ACCURACY; ARTICLE; CONTROLLED STUDY; DIODE; DRUG DEGRADATION; DRUG DETERMINATION; DRUG FORMULATION; DRUG IMPURITY; DRUG MANUFACTURE; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; INFRARED SPECTROSCOPY; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; VALIDATION PROCESS;

ACETONITRILES; BUFFERS; CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITALOPRAM; DIETHYLAMINES; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; METHANOL; ORGANIC CHEMICALS; PEROXIDES; REPRODUCIBILITY OF RESULTS; SOLVENTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 46249125777     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200700410     Document Type: Article

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