Mutation negative "early-onset familial Alzheimer disease": Consider screening for Tau gene mutations

Alzheimer Disease and Associated Disorders

Volumn 22, Issue 2, 2008, Pages 194-195

  Larner, Andrew J ^a  

^a WALTON CENTRE FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

Alzheimer disease; Diagnosis; FTDP 17; Tau mutation

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2; PSEN1 PROTEIN, HUMAN; TAU PROTEIN;

ADULT; ALZHEIMER DISEASE; ARTICLE; CASE REPORT; CHROMOSOME 17; COGNITIVE DEFECT; DISEASE COURSE; FAMILIAL DISEASE; FRONTOTEMPORAL DEMENTIA; GENE; GENE MUTATION; GENETIC SCREENING; HUMAN; MALE; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGICAL TEST; ONSET AGE; PARKINSONISM; PRIORITY JOURNAL; RATING SCALE; RNA SPLICING; TAU GENE; WECHSLER MEMORY SCALE; GENETICS; INTRON; MIDDLE AGED; MUTATION; PHENOTYPE; PHYSIOLOGY;

AGE OF ONSET; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; HUMANS; INTRONS; MALE; MIDDLE AGED; MUTATION; PHENOTYPE; PRESENILIN-1; TAU PROTEINS;

EID: 46249115694     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/WAD.0b013e3181664ea4     Document Type: Article

References (3)

1. van Swieten JC, Stevens M, Rosso SM, et al. Phenotypic variation in hereditary frontotemporal dementia with tau mutations. Ann Neurol. 1999;46:617-626.
2. Mirra SS, Murrell JR, Gearing M, et al. Tau pathology in a family with dementia and a P301L mutation in tau. J Neuropathol Exp Neurol. 1999;8:335-345.
3. Doran M, du Plessis DG, Ghadiali EJ, et al. Familial early-onset dementia with tau intron 10 +16 mutation with clinical features similar to those of Alzheimer disease. Arch Neurol. 2007;64: 1535-1539.