High altitude adaptation: Genetic perspectives

High Altitude Medicine and Biology

Volumn 9, Issue 2, 2008, Pages 140-147

  Stobdan, Tsering ^b   Karar, Jayashree ^b   Pasha, M A Qadar ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b NONE

Author keywords

Genetics; High altitude population; Polymorphism

Indexed keywords

ALDOSTERONE SYNTHASE; BETA 2 ADRENERGIC RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1; MYOGLOBIN; PHOSPHODIESTERASE V;

ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; BRAIN EDEMA; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; HAPLOTYPE; HOMEOSTASIS; HUMAN; HYPOXIA; LUNG EDEMA; NATURAL SELECTION; OXYGEN SENSING; POPULATION GENETICS; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

ACCLIMATIZATION; ADAPTATION, PHYSIOLOGICAL; ALTITUDE SICKNESS; ANOXIA; GENETIC SCREENING; GENOMICS; HUMANS; POLYMORPHISM, GENETIC; RESEARCH DESIGN;

EID: 46249111510     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2007.1076     Document Type: Review

References (99)

1. Haplotype map of the human genome (2005). Nature 437:1299-1320
2. Ahsan A., Charu R., Pasha M.A., Norboo T., Charu R., Afrin F., Ahsan A., and Baig M.A. (2004). eNOS allelic variants at the same locus associate with HAPE and adaptation. Thorax. 59:1000-1002.
3. Ahsan A., Norboo T., Baig M.A., and Qadar Pasha M.A. (2005). Simultaneous selection of the wild-type genotypes of the G894T and 4B/4A polymorphisms of NOS3 associate with high-altitude adaptation. Ann. Hum. Genetics 69:260-267.
4. Ahsan A., Mohd G., Norboo T., Baig M.A., and Pasha M.A. (2006). Heterozygotes of NOS3 polymorphisms contribute to reduced nitrogen oxides in high-altitude pulmonary edema. Chest. 130:1511-1519.
5. Aldashev A.A., Sarybaev A.S., Sydykov A.S., Kalmyrzaev B.B., Kim E.V., Mamanova L.B., Maripov R., Kojonazarov B.K., Mirrakhimov M.M., Wilkins M.R., and Morrell N.W. (2002). Characterization of high-altitude pulmonary hypertension in the Kyrgyz: association with angiotensin-converting enzyme genotype. Am. J. Respir. Crit. Care Med. 166:1396-1402.
6. Aldashev A.A., Kojonazarov B.K., Amatov T.A., Sooronbaev T.M., Mirrakhimov M.M., Morrell N.W., Wharton J., and Wilkins M.R. (2005). Phosphodiesterase type 5 and high altitude pulmonary hypertension. Thorax. 60:683-687.
7. Aldenderfer M.S. (2003). Moving up in the world: archaeologists seek to understand how and when people came to occupy the Andean and Tibetan plateaus. Am. Sci. 91:542-549.
8. Altshuler D., and Daly M. (2007). Guilt beyond a reasonable doubt. Nat. Genetics 39:813-815.
9. Arnaud J., Quilici J.C., and Riviere G. (1981). High-altitude haematology: Quechua-Aymara comparisons. Ann. Hum. Biol. 8:573-578.
10. Barton M., Carmona R., Krieger J.E., Goettsch W., Morawietz H., d'Uscio L.V., Lattmann T., Luscher T.F., and Shaw S. (2000). Endothelin regulates angiotensin-converting enzyme in the mouse kidney. J. Cardiovasc. Pharmacol. 36:S244-S247.
11. Bartsch P., Maggiorini M., Schobersberger W., Shaw S., Rascher W., Girard J., Weidmann P., and Oelz O. (1991). Enhanced exercise-induced rise of aldosterone and vasopressin preceding mountain sickness. J. Appl. Physiol. 71:136-143.
12. Basu M., Malhotra A.S., Pal K., Prasad R., Kumar R., Prasad B.A., and Sawhney R.C. (2007). Erythropoietin levels in lowlanders and high-altitude natives at 3450 m. Aviat. Space Environ. Med. 78:963-967.
13. Bates M.G., Thompson A.A., and Baillie J.K. (2007). Phosphodiesterase type 5 inhibitors in the treatment and prevention of high altitude pulmonary edema. Curr. Opinion Investig. Drugs 8:226-231.
14. Beall C.M. (2007). Two routes to functional adaptation: Tibetan and Andean high-altitude natives. Proc. Natl. Acad. Sci. U.S.A. 104 (suppl. 1):8655-8660.
15. Beall C.M., Brittenham G.M., Strohl K.P., Blangero J., Williams-Blangero S., Goldstein M.C., Decker M.J., Vargas E., Villena M., Soria R., Alarcon A.M., and Gonzales C. (1998). Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara. Am. J. Phys. Anthropol. 106:385-400.
16. Beall C.M., Laskowski D., Strohl K.P., Soria R., Villena M., Vargas E., Alarcon A.M., Gonzales C., and Erzurum S.C. (2001). Pulmonary nitric oxide in mountain dwellers. Nature. 414:411-412.
17. Beall C.M., Decker M.J., Brittenham G.M., Kushner I., Gebremedhin A., and Strohl K.P. (2002). An Ethiopian pattern of human adaptation to high-altitude hypoxia. Proc. Natl. Acad. Sci. U.S.A. 99:17215-17218.
18. +-ATPase activity by membrane insertion of alpha-subunits in lung alveolar cells. Am. J. Physiol. 276:L20-L27.
19. Bigham A.W., Kiyamu M., León-Velarde F., Parra E.J., Rivera-Ch M., Shriver M.D., and Brutsaert T.D. (2008). Angiotensinconverting enzyme genotype and arterial oxygen saturation at high altitude in Peruvian Quechua. High Alt. Med. Biol. 9:167-178.
20. Bowcock A.M. (2007). Genomics: guilt by association. Nature. 447:645-646.
21. Brutsaert T.D. (2007). Population genetic aspects and phenotypic plasticity of ventilatory responses in high altitude natives. Respir. Physiol. Neurobiol. 158:151-160.
22. Brutsaert T.D., Parra E.J., Shriver M.D., Gamboa A., Palacios J.A., Rivera M., Rodriguez I., and León-Velarde F. (2003). Spanish genetic admixture is associated with larger V(O2) max decrement from sea level to 4338 m in Peruvian Quechua. J. Appl. Physiol. 95:519-528.
23. Brutsaert T.D., Parra E., Shriver M., Gamboa A., Palacios J.A., Rivera M., Rodriguez I., and León-Velarde F. (2004). Effects of birthplace and individual genetic admixture on lung volume and exercise phenotypes of Peruvian Quechua. Am. J. Phys. Anthropol. 123:390-398.
24. Brutsaert T.D., Parra E.J., Shriver M.D., Gamboa A., Rivera-Ch M., and León-Velarde F. (2005). Ancestry explains the blunted ventilatory response to sustained hypoxia and lower exercise ventilation of Quechua altitude natives. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289:R225-R234.
25. Carlson C.S., Eberle M.A., Rieder M.J., Smith J.D., Kruglyak L., and Nickerson D.A. (2003). Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat. Genetics 33:518-521.
26. Carlson C.S., Eberle M.A., Rieder M.J., Yi Q., Kruglyak L., and Nickerson D.A. (2004). Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am. J. Hum. Genetics 74:106-120.
27. Carstairs J.R., Nimmo A.J., and Barnes P.J. (1985). Autoradiographic visualization of beta-adrenoceptor subtypes in human lung. Am. Rev. Respir. Dis. 132:541-547.
28. Cavalli-Sforza L.L., and Feldman M.W. (2003). The application of molecular genetic approaches to the study of human evolution. Nat. Genetics 33 (suppl.):266-275.
29. Charu R., Stobdan T., Ram R.B., Khan A.P., Qadar Pasha M.A., Norboo T., and Afrin F. (2006). Susceptibility to high altitude pulmonary oedema: role of ACE and ET-1 polymorphisms. Thorax. 61:1011-1012.
30. Curran L.S., Zhuang J., Sun S.F., and Moore L.G. (1997). Ventilation and hypoxic ventilatory responsiveness in Chinese-Tibetan residents at 3658 m. J. Appl. Physiol. 83:2098-2104.
31. Deng Z., Morse J.H., Slager S.L., Cuervo N., Moore K.J., Venetos G., Kalachikov S., Cayanis E., Fischer S.G., Barst R.J., Hodge S.E., and Knowles J.A. (2000). Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am. J. Hum. Genetics 67:737-744.
32. Dolt K.S., Mishra M.K., Karar J., Baig M.A., Ahmed Z., and Pasha M.A. (2007). cDNA cloning, gene organization and variant specific expression of HIF-1 alpha in high altitude yak (Bos grunniens). Gene. 386:73-80.
33. Droma Y., Hanaoka M., Ota M., Katsuyama Y., Koizumi T., Fujimoto K., Kobayashi T., and Kubo K. (2002). Positive association of the endothelial nitric oxide synthase gene polymorphisms with high-altitude pulmonary edema. Circulation. 106:826-830.
34. Droma Y., Hanaoka M., Basnyat B., Arjyal A., Neupane P., Pandit A., Sharma D., Miwa N., Ito M., Katsuyama Y., Ota M., and Kubo K. (2006). Genetic contribution of the endothelial nitric oxide synthase gene to high altitude adaptation in Sherpas. High Alt. Med. Biol. 7:209-220.
35. Duplain H., Sartori C., Lepori M., Egli M., Allemann Y., Nicod P., and Scherrer U. (2000). Exhaled nitric oxide in high-altitude pulmonary edema: role in the regulation of pulmonary vascular tone and evidence for a role against inflammation. Am. J. Respir. Crit. Care Med. 162:221-224.
36. Erzurum S.C., Ghosh S., Janocha A.J., Xu W., Bauer S., Bryan N.S., Tejero J., Hemann C., Hille R., Stuehr D.J., Feelisch M., and Beall C.M. (2007). Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proc. Natl. Acad. Sci. U.S.A. 104:17593-17598.
37. Frazer K.A., et al. (2007). A second generation human haplotype map of over 3.1 million SNPs. Nature. 449:851-861.
38. Ge R.L., Witkowski S., Zhang Y., Alfrey C., Sivieri M., Karlsen T., Resaland G.K., Harber M., Stray-Gundersen J., and Levine B.D. (2002). Determinants of erythropoietin release in response to short-term hypobaric hypoxia. J. Appl. Physiol. 92:2361-2367.
39. Gelfi C., De P.S., Ripamonti M., Eberini I., Wait R., Bajracharya A., Marconi C., Schneider A., Hoppeler H., and Cerretelli P. (2004). New aspects of altitude adaptation in Tibetans: a proteomic approach. FASEB J. 18:612-614.
40. Gerstein M.B., Bruce C., Rozowsky J.S., Zheng D., Du J., Korbel J.O., Emanuelsson O., Zhang Z.D., Weissman S., and Snyder M. (2007). What is a gene, post-ENCODE? History and updated definition. Genome Res. 17:669-681.
41. Goerre S., Wenk M., Bartsch P., Luscher T.F., Niroomand F., Hohenhaus E., Oelz O., and Reinhart W.H. (1995). Endothelin-1 in pulmonary hypertension associated with high-altitude exposure. Circulation. 91:359-364.
42. Gonzalez-Neira A., Ke X., Lao O., Calafell F., Navarro A., Comas D., Cann H., Bumpstead S., Ghori J., Hunt S., Deloukas P., Dunham I., Cardon L.R., and Bertranpetit J. (2006). The portability of tagSNPs across populations: a worldwide survey. Genome Res. 16:323-330.
43. Hackett P.H., and Roach R.C. (2001). High-altitude illness. N. Engl. J. Med. 345:107-114.
44. Hotta J., Hanaoka M., Droma Y., Katsuyama Y., Ota M., and Kobayashi T. (2004). Polymorphisms of renin-angiotensin system genes with high-altitude pulmonary edema in Japanese subjects. Chest. 126:825-830.
45. Imoberdorf R., Garlick P.J., McNurlan M.A., Casella G.A., Peheim E., Turgay M., Bartsch P., and Ballmer P.E. (2001). Enhanced synthesis of albumin and fibrinogen at high altitude. J. Appl. Physiol. 90:528-537.
46. Jedlickova K., Stockton D.W., Chen H., Stray-Gundersen J., Witkowski S., Ri-Li G., Jelinek J., Levine B.D., and Prchal J.T. (2003). Search for genetic determinants of individual variability of the erythropoietin response to high altitude. Blood Cells Mol. Dis. 31:175-182.
47. Jernigan N.L., and Resta T.C. (2002). Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation. Am. J. Physiol: Lung Cell. Mol. Physiol. 282:L1366-L1375.
48. Julian C.G., Vargas E., Armaza J.F., Wilson M.J., Niermeyer S., and Moore L.G. (2007). High-altitude ancestry protects against hypoxia-associated reductions in fetal growth. Arch. Dis. Child Fetal Neonatal. Ed. 92, F372-F377.
49. Koehle M.S., Wang P., Guenette J.A., and Rupert J.L. (2006). No association between variants in the ACE and angiotensin II receptor 1 genes and acute mountain sickness in Nepalese pilgrims to the Janai Purnima Festival at 4380 m. High Alt. Med. Biol. 7:281-289.
50. Kumar R., Qadar Pasha M.A., Khan A.P., Gupta V., Grover S.K., Norboo T., Srivastava K.K., Selvamurthy W., and Brahamchari S.K. (2003). Association of high-altitude systemic hypertension with the deletion allele of the angiotensin-converting enzyme (ACE) gene. Int. J. Biometeorol. 48:10-14.
51. León-Velarde F., McCullough R.G., McCullough R.E., and Reeves J.T. (2003). Proposal for scoring severity in chronic mountain sickness (CMS): background and conclusions of the CMS Working Group. Adv. Exp. Med. Biol. 543:339-354.
52. Lin C.S., Chow S., Lau A., Tu R., and Lue T.F. (2001). Identification and regulation of human PDE5A gene promoter. Biochem. Biophys. Res. Commun. 280:684-692.
53. Liu K., Sun X., Wang S., and Hu B. (2007a). [Association between polymorphisms of HIF-1alpha C1772T and G1790A and hypoxic acclimation in high altitude in Tibetans.] Sheng Wu Yi. Xue. Gong. Cheng Xue. Za Zhi. 24:654-658.
54. Liu K.X., Sun X.C., Wang S.W., and Hu B. (2007b). [Association of polymorphisms of 1772 (C→T) and 1790 (G→A) in HIF1A gene with hypoxia adaptation in high altitude in Sherpas.] Zhonghua Yi. Xue. Yi. Chuan Xue. Za Zhi. 24:230-232.
55. Mao X., Bigham A.W., Mei R., Gutierrez G., Weiss K.M., Brutsaert T.D., León Velarde F., Moore L.G., Vargas E., McKeigue P.M., Shriver M.D., and Parra E.J. (2007). A genomewide admixture mapping panel for Hispanic/Latino populations. Am. J. Hum. Genetics 80:1171-1178.
56. Mazzeo R.S., and Reeves J.T. (2003). Adrenergic contribution during acclimatization to high altitude: perspectives from Pikes Peak. Exerc. Sport Sci. Rev. 31:13-18.
57. Milledge J.S., and Cotes P.M. (1985). Serum erythropoietin in humans at high altitude and its relation to plasma renin. J. Appl. Physiol. 59:360-364.
58. Milledge J.S., Catley D.M., Ward M.P., Williams E.S., and Clarke C.R. (1983). Renin-aldosterone and angiotensin-converting enzyme during prolonged altitude exposure. J. Appl. Physiol. 55:699-702.
59. Modesti P.A., Vanni S., Morabito M., Modesti A., Marchetta M., Gamberi T., Sofi F., Savia G., Mancia G., Gensini G.F., and Parati G. (2006). Role of endothelin-1 in exposure to high altitude: acute mountain sickness and endothelin-1 (ACME-1) study. Circulation. 114:1410-1416.
60. Monge C.C., and Whittembury J. (1976). Chronic mountain sickness. Johns Hopkins Med. J. 139(suppl.):87-89.
61. Montgomery H.E., Marshall R., Hemingway H., Myerson S., Clarkson P., Dollery C., Hayward M., Holliman D.E., Jubb M., World M., Thomas E.L., Brynes A.E., Saeed N., Barnard M., Bell J.D., Prasad K., Rayson M., Talmud P.J., and Humphries S.E. (1998). Human gene for physical performance. Nature. 393:221-222.
62. Moore L.G., Zamudio S., Zhuang J., Droma T., and Shohet R.V. (2002). Analysis of the myoglobin gene in Tibetans living at high altitude. High Alt. Med. Biol. 3:39-47.
63. Morganti A., Giussani M., Sala C., Gazzano G., Marana I., Pierini A., Savoia M.T., Ghio F., Cogo A., and Zanchetti A. (1995). Effects of exposure to high altitude on plasma endothelin-1 levels in normal subjects. J. Hypertens. 13:859-865.
64. Morrell N.W., Sarybaev A.S., Alikhan A., Mirrakhimov M.M., and Aldashev A.A. (1999). ACE genotype and risk of high altitude pulmonary hypertension in Kyrghyz highlanders. Lancet. 353:814.
65. Mortimer H., Patel S., and Peacock A.J. (2004). The genetic basis of high-altitude pulmonary oedema. Pharmacol. Ther. 101:182-192.
66. Myerson S., Hemingway H., Budget R., Martin J., Humphries S., and Montgomery H. (1999). Human angiotensin I-converting enzyme gene and endurance performance. J. Appl. Physiol 87:1313-1316.
67. Nei M., and Roychoudhury A.K. (1974). Genic variation within and between the three major races of man, Caucasoids, Negroids, and Mongoloids. Am. J. Hum. Genetics 26:421-443.
68. Patel S., Woods D.R., Macleod N.J., Brown A., Patel K.R., Montgomery H.E., and Peacock A.J. (2003). Angiotensin-converting enzyme genotype and the ventilatory response to exertional hypoxia. Eur. Respir. J. 22:755-760.
69. Prior S.J., Hagberg J.M., Phares D.A., Brown M.D., Fairfull L., Ferrell R.E., and Roth S.M. (2003). Sequence variation in hypoxia-inducible factor 1alpha (HIF1A): association with maximal oxygen consumption. Physiol. Genomics. 15:20-26.
70. Qadar Pasha M.A., Khan A.P., Kumar R., Grover S.K., Ram R.B., Norboo T., Srivastava K.K., Selvamurthy W., and Brahmachari S.K. (2001). Angiotensin converting enzyme insertion allele in relation to high altitude adaptation. Ann. Hum. Genetics 65:531-536.
71. Rajput C., Arif E., Vibhuti A., Stobdan T., Khan A.P., Norboo T., Afrin F., and Qadar Pasha M.A. (2006a). Predominance of interaction among wild-type alleles of CYP11B2 in Himalayan natives associates with high-altitude adaptation. Biochem. Biophys. Res. Commun. 348:735-740.
72. Rajput C., Najib S., Norboo T., Afrin F., and Qadar Pasha M.A. (2006b). Endothelin-1 gene variants and levels associate with adaptation to hypobaric hypoxia in high-altitude natives. Biochem. Biophys. Res. Commun. 341:1218-1224.
73. Reich D., Patterson N., De Jager P.L., McDonald G.J., Waliszewska A., Tandon A., Lincoln R.R., DeLoa C., Fruhan S.A., Cabre P., Bera O., Semana G., Kelly M.A., Francis D.A., Ardlie K., Khan O., Cree B.A., Hauser S.L., Oksenberg J.R., and Hafler D.A. (2005). A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat. Genetics 37:1113-1118.
74. Rosenberg N.A., Pritchard J.K., Weber J.L., Cann H.M., Kidd K.K., Zhivotovsky L.A., and Feldman M.W. (2002). Genetic structure of human populations. Science. 298:2381-2385.
75. Rupert J.L., and Hochachka P.W. (2001). Genetic approaches to understanding human adaptation to altitude in the Andes. J. Exp. Biol. 204:3151-3160.
76. Rupert J.L., and Koehle M.S. (2006). Evidence for a genetic basis for altitude-related illness. High Alt. Med. Biol. 7:1-150.
77. Rupert J.L., Devine D.V., Monsalve M.V., and Hochachka P.W. (1999). Beta-fibrinogen allele frequencies in Peruvian Quechua, a high-altitude native population. Am. J. Phys. Anthropol. 109:181-186.
78. Rupert J.L., Monsalve M.V., Devine D.V., and Hochachka P.W. (2000). Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population. Ann. Hum. Genetics 64:135-143.
79. Rupert J.L., Kidd K.K., Norman L.E., Monsalve M.V., Hochachka P.W., and Devine D.V. (2003). Genetic polymorphisms in the renin-angiotensin system in high-altitude and low-altitude Native American populations. Ann. Hum. Genetics 67:17-25.
80. Sabeti P.C., et al. (2007). Genome-wide detection and characterization of positive selection in human populations. Nature. 449:913-918.
81. Sartori C., Vollenweider L., Loffler B.M., Delabays A., Nicod P., Bartsch P., and Scherrer U. (1999). Exaggerated endothelin release in high-altitude pulmonary edema. Circulation. 99:2665-2668.
82. Sartori C., Allemann Y., Duplain H., Lepori M., Egli M., Lipp E., Hutter D., Turini P., Hugli O., Cook S., Nicod P., and Scherrer U. (2002). Salmeterol for the prevention of high-altitude pulmonary edema. N. Engl. J. Med. 346:1631-1636.
83. Semenza G.L. (1999). Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell. Dev. Biol. 15:551-578.
84. Shriver M.D., Mei R., Bigham A., Mao X., Brutsaert T.D., Parra E.J., and Moore L.G. (2006). Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping. Adv. Exp. Med. Biol. 588:89-100.
85. Smith E.M., Baillie J.K., Thompson A.A., Irving J.B., Porteous D., and Webb D.J. (2006). Endothelial nitric oxide synthase polymorphisms do not influence pulmonary artery systolic pressure at altitude. High Alt. Med. Biol. 7:221-227.
86. Suzuki K., Kizaki T., Hitomi Y., Nukita M., Kimoto K., Miyazawa N., Kobayashi K., Ohnuki Y., and Ohno, H. (2003). Genetic variation in hypoxia-inducible factor 1alpha and its possible association with high altitude adaptation in Sherpas. Med. Hypotheses 61:385-389.
87. Tang H., Quertermous T., Rodriguez B., Kardia S.L., Zhu X., Brown A., Pankow J.S., Province M.A., Hunt S.C., Boerwinkle E., Schork N.J., and Risch, N.J. (2005). Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am. J. Hum. Genetics 76:268-275.
88. Tesauro M., Thompson W.C., Rogliani P., Qi L., Chaudhary P.P., and Moss J. (2000). Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc. Natl. Acad. Sci. U.S.A. 97:2832-2835.
89. Vargas M., Vargas E., Julian C.G., Armaza J.F., Rodriguez A., Tellez W., Niermeyer S., Wilson M., Parra E., Shriver M., and Moore L.G. (2007). Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293:R1303-R1312.
90. Voight B.F., Kudaravalli S., Wen X., and Pritchard J.K. (2006). A map of recent positive selection in the human genome. PLoS. Biol. 4:e72.
91. Wang G.L., Jiang B.H., Rue E.A., and Semenza G.L. (1995). Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2tension. Proc. Natl. Acad. Sci. U.S.A. 92:5510-5514.
92. Wang P., Koehle M.S., and Rupert J.L. (2007). Common haplotypes in the beta-2 adrenergic receptor gene are not associated with acute mountain sickness susceptibility in Nepalese. High Alt. Med. Biol. 8:206-212.
93. Ward M.P., Milledge J.S., and West J.B. (2000). High Altitude Physiology and Medicine, 3rd ed. Arnold, London.
94. Weiss J., Haefeli W.E., Gasse C., Hoffmann M.M., Weyman J., Gibbs S., Mansmann U., and Bartsch P. (2003). Lack of evidence for association of high altitude pulmonary edema and polymorphisms of the NO pathway. High Alt. Med. Biol. 4:355-366.
95. Wilson M.J., Lopez M., Vargas M., Julian C., Tellez W., Rodriguez A., Bigham A., Armaza J.F., Niermeyer S., Shriver M., Vargas E., and Moore L.G. (2007). Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293:R1313-R1324.
96. Woods D.R., Pollard A.J., Collier D.J., Jamshidi Y., Vassiliou V., Hawe E., Humphries S.E., and Montgomery H.E. (2002). Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene and arterial oxygen saturation at high altitude. Am. J. Respir. Crit. Care Med. 166:362-366.
97. Wu X., Chang M.S., Mitsialis S.A., and Kourembanas S. (2006). Hypoxia regulates bone morphogenetic protein signaling through C-terminal-binding protein 1. Circ. Res. 99:240-247.
98. Yamashita K., Discher D.J., Hu J., Bishopric N.H., and Webster K.A. (2001). Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, and p300/CBP. J. Biol. Chem. 276:12645-12653.
99. Zhuang J., Droma T., Sun S., Janes C., McCullough R.E., McCullough R.G., Cymerman A., Huang S.Y., Reeves J.T., and Moore L.G. (1993). Hypoxic ventilatory responsiveness in Tibetan compared with Han residents of 3658 m. J. Appl. Physiol. 74:303-311.