Neurotoxicity of Micrurus altirostris (Uruguayan coral snake) venom and its neutralization by commercial coral snake antivenom and specific antiserum raised in rabbits

Clinical Toxicology

Volumn 46, Issue 6, 2008, Pages 519-527

  De Abreu, Valdemir Aparecido ^a   Leite, Gildo Bernardo ^a   Oliveira, Caroline Borja ^a   Hyslop, Stephen ^a   Furtado, Maria De Fátima Domingos ^b   Simioni, Léa Rodrigues ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b INSTITUTO BUTANTAN   (Brazil)

Author keywords

Antivenom; Blockade; Neurotransmission; Neutralization; Postsynaptic neurotoxin

Indexed keywords

ACETYLCHOLINE; CARBACHOL; NEOSTIGMINE; RABBIT ANTISERUM; SNAKE VENOM; SNAKE VENOM ANTISERUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHICK; CONTROLLED STUDY; LETHAL DOSE; LETHALITY; MALE; MICRURUS ALTIROSTRIS; MOUSE; NEUROMUSCULAR BLOCKING; NEUROMUSCULAR FUNCTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; RABBIT; SNAKE;

ACETYLCHOLINE; ANIMALS; ANTIVENINS; CALCIUM; CARBACHOL; CHICKENS; ELAPID VENOMS; ELAPIDAE; HORSES; IMMUNE SERA; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAPERITONEAL; LETHAL DOSE 50; MALE; MICE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PHRENIC NERVE; RABBITS; SYNAPTIC TRANSMISSION; TEMPERATURE;

MICRURUS; MICRURUS ALTIROSTRIS; MUS; ORYCTOLAGUS CUNICULUS;

EID: 46249106845     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650701647405     Document Type: Article

References (37)

1. Campbell JA, Lamar WW. The venomous reptiles of the western hemisphere. Cornell University Press: Ithaca, 2004.
2. Warrell, DA. Snakebites in Central and South America: epidemiology, clinical features and clinical management. In Venomous Reptiles of the Western Hemisphere, eds. Campbell, JA & Lamar, WW. Ithaca: Comstock Publishing Associates/Cornell University Press 2004; 2:709-761.
3. Ministério da Saúde do Brasil. Manual de diagnóstico e tratamento de acidentes por animais peçonhentos. Brasília, DF: Fundação Nacional de Saúde, 1998.
4. Jorge da Silva Jr. N, Bucaretchi F. Mecanismo de ação do veneno elapídico e aspectos clínicos dos acidentes. In: Cardoso JLC, França FOS, Wen FH, Málaque CMS, Haddad Jr. V, eds. Animais peçonhentos no Brasil: Biologia, clínica e terapêutica dos acidentes. São Paulo: Sarvier/FAPESP, 2003; 99-107.
5. Bucaretchi F, Hyslop S, Vieira RJ, Toledo AS, Madureira PR, de Capitani EM. Bites by coral snakes (Micrurus spp.) in Campinas, state of São Paulo, southeastern Brazil. Rev Inst Med Trop São Paulo 2006; 48:141-145.
6. Russell FE. Snake venom poisoning. New York: Scholium, 1983.
7. Bolaños R. Serpientes, venenos y ofidismo en Centroamerica. San José, Costa Rica: Editorial Universidad de Costa Rica, 1984.
8. Jorge da Silva Jr. N, Griffin PR, Aird SD. Comparative chromatography of Brazilian coral snake (Micrurus) venoms. Comp Biochem Physiol B 1991; 100(1):117-126.
9. Alape-Girón A, Gustafsson B, Lomonte B, Thelestam M, Gutiérrez JM. Immunochecimal characterization of Micrurus nigrocinctus venom with monoclonal and polyclonal antibodies. Toxicon 1994; 32:695-712.
10. Raw I, Guidolin R, Higashi H, Kelen EMA. Antivenins in Brazil: Preparation. In: Tu AT, ed. Handbook of natural toxins. Vol. 5. New York: Marcel Dekker, 1991; 557-581.
11. Bolaños R, Cerdas L, Abalos JW. Venoms of coral snakes (Micrurus spp): report on a multivalent antivenin for the Americas. Bull Pan-Am Health Org 1978; 12:23-27.
12. Berger BJ, Bhatti AR. Snake venoms components and their crossreactivity: A review. Biochem Cell Biol 1989; 67:597-601.
13. Cohen P, Seligmann Jr EB. Immunologic studies of coral snake venoms. Mem Inst Butantan 1966; 33:339-347.
14. Higashi HG, Guidolin R, Caricati CP, Fernandes I, Marcelino JR, Morais JF, Yamagushi IK, Stephano MA, Dias-da-Silva W, Takehara HA. Antigenic cross-reactivity among components of Brazilian Elapidae snake venoms. Braz J Med Biol Res 1995; 28:767-771.
15. Melgarejo AR. Serpentes peçonhentas do Brasil. In: Cardoso JLC, França FOS, Wen FH, Málaque CMS, Haddad Jr. V, eds. Animais Peçonhentos no Brasil: Biologia, clínica e terapêutica dos acidentes. São Paulo: Sarvier/FAPESP, 2003; 33-61.
16. Moraes FV, Sousa-e-Silva MV, Barbaro KC, Leitão MA, Furtado MF. Biological and immunochemical characterization of Micrurus altirostris venom and serum neutralization of its toxic activities. Toxicon 2003; 41:71-79.
17. Ouchterlony O. Antigen-antibody reactions in gels. Acta Pathol Microbiol Scand 1949; 26: 507-515.
18. Ginsborg BL, Warriner J. The isolated chick biventer cervicis nervemuscle preparation. Br J Pharmacol 1960; 15:410-411.
19. Harvey AL, Barfaraz A, Thomson E, Faiz A, Preston S, Harris JB. Screening of snake venoms for neurotoxic and myotoxic effects using simple in vitro preparations from rodents and chicks. Toxicon 1994; 32:257-265.
20. Bülbring E. Observations on the isolated phrenic nerve-diaphragm preparation of the rat. Br J Pharmacol 1946; 1:38-61.
21. Finney PJ. Probit analysis. 3rd ed. Cambridge: Cambridge University Press, 1971.
22. Gutiérrez JM, Rojas G, Lomonte B, Gené JA, Chaves F. La evaluación de la capacidad neutralizante de los antivenenos em América. San Juan, Costa Rica: Instituto Clodomiro Picado, Universidad de Costa Rica, 1990.
23. Vital Brazil O. Ação neuromuscular da peçonha de Micrurus. O Hospital 1965; 68:183-224.
24. Goularte FC, Cogo JC, Gutiérrez JM, Rodrigues-Simioni L. The ability of specific antivenom and low temperature to inhibit the myotoxicity and neuromuscular block induced by Micrurus nigrocinctus venom. Toxicon 1995; 33:679-689.
25. Serafim FG, Reali MR, Cruz-Höfling MA, Fontana MD. Action of Micrurus dumerilii carinicauda coral snake venom on the mammalian neuromuscular junction. Toxicon 2002; 40:167-174.
26. Cecchini AL, Marcussi S, Silveira LB, Borja-Oliveira CR, Rodrigues-Simioni L, Amara S, Stabeli RG, Giglio JR, Arantes EC, Soares AM. Biological and enzymatic activities of Micrurus sp. (coral) snake venoms. Comp Biochem Physiol A. Mol Integr Physiol 2005; 140:125-134.
27. Vital Brazil O, Fontana MD. Ações pré-juncionais e pós-juncionais da peçonha da cobra coral Micrurus corallinus na junção neuromuscular. Mem Inst Butantan 1983; 47/48:13-26.
28. Cruz-Höfling MA, Rodrigues-Simioni L, Vital Brazil O. Ultrastructural changes in neuromuscular junctions of mouse diaphragm caused by the venom of the coral snake Micrurus corallinus. Mem Inst Butantan 1983/1984; 47/48:95-105.
29. Vital Brazil O, Fontana MD, Pellegrini Filho A. Physiophatologie et thérapeutique de l'envenomation espérimentale causée par le venin de Micrurus frontalis. Mem Inst Butantan 1976/1977; 40/41:221-240.
30. Vital Brazil O, Fontana MD, Heluany NF, Laure CJ. Mode of action of the coral snake Micrurus spixii venom at the neuromuscular junction. J. Nat Toxins 1995;4:19-33.
31. Jorge da Silva Jr. N, Aird SD. Prey specificity, comparative lethality and compositional differences of coral snake venoms. Comp Biochem Physiol C Toxicol Pharmacol 2001;128:425-456.
32. Vital Brazil O, Vieira RJ. Neostigmine in the treatment of snake accidents caused by Micrurus frontalis: report of two cases. Rev Inst Med Trop São Paulo 1996; 38:61-67.
33. Kitchens CS, Van Mierop LHS. Envenomation by the eastern coral snake (Micrurus fulvius fulvius). JAMA 1987; 258:1615-1618.
34. Norris LM, Dart RC. Apparent coral snake envenomation in a patient without visible fang marks. Am J Emerg Med 1989; 7:402-405.
35. Amuy E, Alapé-Girón A, Lomonte B, Thelestam M, Gutiérrez JM. Development of immunoassays for determination of circulating venom antigens during envenomation by coral snakes (Micrurus species). Toxicon 1997; 35:1605-1616.
36. Prieto da Silva ARB, Yamagushi IK, Morais JF, Higashi HG, Raw I, Ho PL, Oliveira JS. Cross reactivity of different specific Micrurus antivenom sera with homologous snake venoms. Toxicon 2001; 39:949-953.
37. de Roodt AR, Paniagua-Solis JF, Dolab JA, Estévez-Ramiréz J, Ramos-Cerrillo B, Litwin S, Dokmetjian JC, Alagón A. Effectiveness of two common antivenoms for North, Central and South American Micrurus envenomations. J Toxicol Clin Toxicol 2004; 42:171-178.