Therapeutic effects of molecularly designed antigen UREB138 for mice infected with helicobacter pylori

Biotechnology and Bioengineering

Volumn 100, Issue 4, 2008, Pages 634-643

  Morihara, Fumiko ^a,b   Hifumi, Emi ^b,c   Yamada, Manabu ^d   Nishizono, Akira ^b,e   Uda, Taizo ^b,c  

^a Fukuyama Medical Laboratory Co   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c OITA UNIVERSITY   (Japan)

^d PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^e OITA UNIVERSITY   (Japan)

Author keywords

Antibacterial; Immune response; Immuno chemistry; Infection; Inflammation; Microbiology

Indexed keywords

ANTIGENS; BIOMOLECULES; IMMUNIZATION; MOLECULES; PAINTING; WEIGHT CONTROL;

BACTERIAL NUMBERS; CHEMICAL STAINING; CHRONIC GASTRITIS; GASTRIC MUCOSA; HELICOBACTER PYLORI; HELICOBACTER PYLORI (H. PYLORI); IN CONTROL; INTERFERON-GAMMA; PEPTIC ULCERS; RECOMBINANT PROTEINS; UREASE ACTIVITY;

BACTERIOLOGY;

GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; MESSENGER RNA; PROTEIN UREB138; RECOMBINANT PROTEIN; UREASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; C57BL 6 MOUSE; CHRONIC GASTRITIS; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PEPTIC ULCER; PERSISTENT INFECTION; REPEATED DRUG DOSE; STOMACH MUCOSA; TH1 CELL; TH2 CELL; VACCINATION;

ANIMALS; ANTIGENS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; GASTRIC MUCOSA; GENE EXPRESSION; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INJECTIONS, SUBCUTANEOUS; INTERFERON TYPE II; MICE; MICE, INBRED STRAINS; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; UREASE;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI; MUS;

EID: 46249106054     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21804     Document Type: Article

References (41)

1. Akhiani AA, Pappo J, Kabok Z, Schon K, Gao W, Franzen LE, Lycke N. 2002. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 169:6977-6984.
2. Allen LH, Schlesinger LS, Kang B. 2000. Virulent strains of Helicobacter pylori demonstrate delayed phagocytosis and stimulate homotypic phagosome fusion in macrophages. J Exp Med 191:115-127.
3. Bardhan PK. 1997. Epidemiological features of Helicobacter pylori infection in developing countries. Clin Infect Dis 25:973-978.
4. Blaser MJ. 1990. Helicobacter pylori and the pathogenesis of gastroduodenal inflammation. J Infect Dis 161:626-633.
5. Corthesy-Theulaz I, Porta N, Glauser M, Saraga E, Vaney AC, Haas R, Kraehenbuhl JP, Blum AL, Michetti P. 1995. Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice. Gastroenterology 109:115-121.
6. Cover TL, Blaser MJ. 1992. Helicobacter pylori and gastroduodenal disease. Annu Rev Med 43:135-145.
7. Cuenca R, Blanchard TG, Czinn SJ, Nedrud JG, Monath TP, Lee CK, Redline RW. 1996. Therapeutic immunization against Helicobacter mustelae in naturally infected ferrets. Gastroenterology 110:1770-1775.
8. Czinn SJ, Cai A, Nedrud JG. 1993. Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization. Vaccine 11:637-642.
9. Doidge C, Crust I, Lee A, Buck F, Hazell S, Manne U. 1994. Therapeutic immunization against Helicobacter infection. Lancet 343:914-915.
10. Dunn BE, Campbell GP, Perez-Perez GI, Blaser MJ. 1990. Purification and characterization of urease from Helicobacter pylori. J Biol Chem 265:9464-9469.
11. Dunn BE, Vakil NB, Schneider BG, Miller MM, Zitzer JB, Peutz T, Phadnis SH. 1997. Localization of Helicobacter pylori urease and heat shock protein in human gastric biopsies. Infect Immun 65:1181-1188.
12. Eidt S, Stolte M. 1994. Prevalence of intestinal metaplasia in Helicobacter pylori gastritis. Scand J Gastroenterol 29:607-610.
13. Ermak TH, Giannasca PJ, Nichols R, Myers GA, Nedrud J, Weltzin R, Lee CK, Kleanthous H, Monath TP. 1998. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses. J Exp Med 188:2277-2288.
14. Fujii R, Morihara F, Fukushima K, Oku T, Hifumi E, Uda T. 2004. Recombinant antigen from Helicobacter pylori urease as vaccine against H. pylori-associated disease. Biotechnol Bioeng 86:737-746.
15. Garhart CA, Nedrud JG, Heinzel FP, Sigmund NE, Czinn SJ. 2003. Vaccine-induced protection against Helicobacter pylori in mice lacking both antibodies and interleukin-4. Infect Immun 71:3628-3633.
16. Ghiara P, Rossi M, Marchetti M, Di Tommaso A, Vindigni C, Ciampolini F, Covacci A, Telford JL, De Magistris MT, Pizza M, Rappuoli R, Del Giudice G. 1997. Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection. Infect Immun 65:4996-5002.
17. Goto T, Nishizono A, Fujioka T, Ikewaki J, Mifune K, Nasu M. 1999. Local secretory immunoglobulin A and postimmunization gastritis correlate with protection against Helicobacter pylori infection after oral vaccination of mice. Infect Immun 67:2531-2539.
18. Gottwein JM, Blanchard TG, Targoni OS, Eisenberg JC, Zagorski BM, Redline RW, Nedrud JG, Tary-Lehmann M, Lehmann PV, Czinn SJ. 2001. Protective anti-Helicobacter immunity is induced with aluminum hydroxide or complete Freund's adjuvant by systemic immunization. J Infect Dis 184:308-314.
19. Graham DY, Malaty HM, Evans DG, Evans DJ, Jr., Klein PD, Adam E. 1991. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology 100:1495-1501.
20. Guy B, Hessler C, Fourage S, Rokbi B, Millet MJ. 1999. Comparison between targeted and untargeted systemic immunizations with adjuvanted urease to cure Helicobacter pylori infection in mice. Vaccine 17: 1130-1135.
21. Ha NC, Oh ST, Sung JY, Cha KA, Lee MH, Oh BH. 2001. Supramolecular assembly and acid resistance of Helicobacter pylori urease. Nat Struct Biol 8:505-509.
22. Hawtin PR, Stacey AR, Newell DG. 1990. Investigation of the structure and localization of the urease of Helicobacter pylori using monoclonal antibodies. J Gen Microbiol 136:1995-2000.
23. Hu LT, Mobley HL. 1990. Purification and N-terminal analysis of urease from Helicobacter pylori. Infect Immun 58:992-998.
24. Ikeda Y, Fujii R, Ogino K, Fukushima K, Hifumi E, Uda T. 1998. Immunological features and inhibitory effects on enzymatic activity of monoclonal antibodies against Helicobacter pylori urease. J Ferment Bioeng 86:271-276.
25. Ikewaki J, Nishizono A, Goto T, Fujioka T, Mifune K. 2000. Therapeutic oral vaccination induces mucosal immune response sufficient to eliminate long-term Helicobacter pylori infection. Microbiol Immunol 44: 29-39.
26. Lee CK, Weltzin R, Thomas WD, Jr., Kleanthous H, Ermak TH, Soman G, Hill JE, Ackerman SK, Monath TP. 1995. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis. J Infect Dis 172:161-172.
27. Maeda K, Yamashiro T, Minoura T, Fujioka T, Nasu M, Nishizono A. 2002. Evaluation of therapeutic efficacy of adjuvant Helicobacter pylori whole cell sonicate in mice with chronic H. pylori infection. Microbiol Immunol 46:613-620.
28. Malfertheiner P. 1993. Compliance, adverse events and antibiotic resistance in Helicobacter pylori treatment. Scand J Gastroenterol Suppl 196:34-37.
29. Marshall BJ, Warren JR. 1984. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1:1311-1315.
30. Mobley HL, Island MD, Hausinger RP. 1995. Molecular biology of microbial ureases. Microbiol Rev 59:451-480.
31. Mohammadi MS, Czinn S, Redline R, Nedrud J. 1996. Helicobacter specific cell-mediated immune responses display a predominant Th1 pheno-type and promote a delayed-type hypersensitivity response in the stomachs of mice. J Immunol 156:4729-4738.
32. Morihara F, Fujii R, Hifumi E, Nishizono A, Uda T. 2007. Effects of vaccination by a recombinant antigen ureB138 (a segment of the β-subunit of urease) against Helicobacter pylori infection. J Med Microbiol 56:847-853.
33. Nielsen H, Andersen LP. 1992. Chemotactic activity of Helicobacter pylori sonicate for human polymorphonuclear leucocytes and monocytes. Gut 33:738-742.
34. Pappo J, Thomas WD, Jr., Kabok Z, Taylor NS, Murphy JC, Fox JG. 1995. Effect of oral immunization with recombinant urease on murine Helicobacter felis gastritis. Infect Immun 63:1246-1252.
35. Raghavan S, Hjulstrom M, Holmgren J, Svennerholm AM. 2002. Protection against experimental Helicobacter pylori infection after immunization with inactivated H. pylori whole-cell vaccines. Infect Immun 70:6383-6388.
36. Raghavan S, Svennerholm AM, Holmgren J. 2002. Effects of oral vaccination and immunomodulation by cholera toxin on experimental Helicobacter pylori infection, reinfection, and gastritis. Infect Immun 70:4621-4627.
37. Saldinger PF, Porta N, Launois P, Louis JA, Waanders GA, Bouzourene H, Michetti P, Blum AL, Corthesy-Theulaz IE. 1998. Immunization of BALB/c mice with Helicobacter urease B induces a T helper 2 response absent in Helicobacter infection. Gastroenterology 115:891-897.
38. Sutton P, Wilson J, Kosaka T, Wolowczuk I, Lee A. 2000. Therapeutic immunization against Helicobacter pylori infection in the absence of antibodies. Immunol Cell Biol 78:28-30.
39. Takishima K, Suga T, Mamiya G. 1998. The structure of jack bean urease. The complete amino acid sequence, limited proteolysis and reactive cysteine residues. Eur J Biochem 175:151-165.
40. Tsuda M, Karita M, Morshed MG, Okita K, Nakazawa T. 1994. A urease-negative mutant of Helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomach. Infect Immun 62:3586-3589.
41. Yamaguchi H, Osaki T, Kai M, Taguchi H, Kamiya S. 2000. Immune response against a cross-reactive epitope on the heat shock protein 60 homologue of Helicobacter pylori. Infect Immun 68:3448-3454.