Intracellular localization of Cthrc1 characterizes differentiated smooth muscle

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 28, Issue 7, 2008, Pages 1332-1338

  Leclair, Renée J ^a   Wang, Qiaozeng ^a   Benson, Meredith A ^a   Prudovsky, Igor ^a   Lindner, Volkhard ^a  

^a Maine Medical Center Research Institute   (United States)

Author keywords

Differentiation; Plasmin; Smooth muscle

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CELL PROTEIN; COLLAGEN TRIPLE HELIX REPEAT CONTAINING 1 PROTEIN; MESSENGER RNA; PLASMIN; PROCOLLAGEN; PROTEIN ANTIBODY; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; CTHRC1 PROTEIN, HUMAN; CTHRC1 PROTEIN, RAT; GLYCOPROTEIN; SCLEROPROTEIN;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTERY INJURY; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CYTOPLASM; EMBRYO; EXTRACELLULAR MATRIX; HEART MUSCLE; IMMUNOBLOTTING; IMMUNOREACTIVITY; INTESTINE MUSCLE; INTIMA; MOUSE; MYOMETRIUM; NERVE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS INHIBITION; SMOOTH MUSCLE FIBER; TISSUE DIFFERENTIATION; VASCULAR SMOOTH MUSCLE; ANIMAL; BIOSYNTHESIS; CAROTID ARTERY INJURY; CELL DIFFERENTIATION; CHO CELL; CRICETULUS; DISEASE MODEL; ENZYMOLOGY; FEMALE; GENETIC TRANSDUCTION; GENETICS; HAMSTER; HEART PAPILLARY MUSCLE; HUMAN; METABOLISM; PRENATAL DEVELOPMENT; PROTEIN TRANSPORT; SKELETAL MUSCLE; SMOOTH MUSCLE; SWINE; TRANSGENIC MOUSE;

ANIMALS; CAROTID ARTERY INJURIES; CELL DIFFERENTIATION; CHO CELLS; CRICETINAE; CRICETULUS; CYTOPLASM; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GLYCOPROTEINS; HUMANS; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; MYOMETRIUM; PAPILLARY MUSCLES; PLASMIN; PROCOLLAGEN; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; SWINE; TRANSDUCTION, GENETIC;

EID: 46249090087     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.108.166579     Document Type: Article

References (10)

1. LeClair RJ, Durmus T, Wang Q, Pyagay P, Terzic A, Lindner V. Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation. Circ Res. 2007;100:826-833.
2. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 2004;84:767-801.
3. Majesky MW, Lindner V, Twardzik DR, Schwartz SM, Reidy MA. Production of transforming growth factor beta 1 during repair of arterial injury. J Clin. Invest. 1991;88:904-910.
4. Lindner V. Role of basic fibroblast growth factor and platelet-derived growth factor (B-chain) in neointima formation after arterial injury. Z Kardial. 1995;84 Suppl 4:137-144.
5. Kumar A, Lindner V. Remodeling with neointima formation in the mouse carotid artery after cessation, of blood flow. Arterioscler Thromb Vase Biol. 1997;17:2238-2244.
6. Flaumenhaft R, Abe M, Sato Y, Miyazono K, Harpel J, Heldin. CH, Rifkin DB. Role of the latent TGF-beta binding protein in the activation, of latent TGF-beta by co-cultures of endothelial and smooth muscle cells. J Cell Biol. 1993;120:995-1002.
7. Durmus T, Leclair RJ, Park KS, Terzic A, Yoon JK, Lindner V. Expression analysis of the novel gene collagen, triple helix repeat containing-1 (Cthrcl). Gene Expr Patterns. 2006;6:935-940.
8. Jackson CL, Reidy MA. The role of plasminogen activation in smooth muscle cell migration after arterial injury. Ann N Y Acad Sci. 1992;667: 141-150.
9. Pyagay P, Heroult M, Wang Q, Lehnert W, Belden J, Liaw L, Friesel RE, Lindner V. Collagen triple helix repeat containing 1, a novel secreted protein, in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ Res. 2005;96:261-268.
10. Takahashi Y, Imanaka T, Takano T. Spatial and temporal pattern of smooth muscle cell differentiation during development of the vascular system in the mouse embryo. Anat Embryol (Berl). 1996;194:515-526.