Quantitative trait loci for bone lengths on chromosome 5 using dual energy X-ray absorptiometry imaging in the twins UK cohort

PLoS ONE

Volumn 3, Issue 3, 2008, Pages

  Chinappen Horsley, Usha ^a,b   Blake, Glen M ^b   Fogelman, Iganac ^b   Kato, Bernet ^a   Ahmadi, Kourosh R ^a   Spector, Tim D ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BODY HEIGHT; BONE DISEASE; CALCULATION; CAUCASIAN; CHROMOSOME 5Q; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION COEFFICIENT; DIZYGOTIC TWINS; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; GENETIC IDENTIFICATION; GENETIC LINKAGE; HERITABILITY; HUMAN; HUMERUS; LINKAGE ANALYSIS; MONOZYGOTIC TWINS; PHENOTYPE; POPULATION RESEARCH; QUANTITATIVE TRAIT LOCUS; RADIUS; SPINE; TIBIA; UNITED KINGDOM; BONE; CHROMOSOME 5; GENOME; HISTOLOGY; METHODOLOGY; PHOTON ABSORPTIOMETRY; RADIOGRAPHY; TWINS;

ABSORPTIOMETRY, PHOTON; BONE AND BONES; CHROMOSOMES, HUMAN, PAIR 5; COHORT STUDIES; GENOME, HUMAN; HUMANS; LOD SCORE; QUANTITATIVE TRAIT LOCI;

EID: 46149126156     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001752     Document Type: Article

References (34)

1. Silventoinen K, Sammalisto S, Perola M, Boomsma DI, Comes BK et al (2003) Heritability of adult body height: a comparative study of twin cohorts in eight countries. Twin Res 6: 399-408.
2. Sale MM, Freedman BI, Hicks PJ, Williams AH, Langefeld CD, et al. (2005) Loci contributing to adult height and body mass index in African American families ascertained for type 2 diabetes. Am Hum Genet 69: 517-27.
3. Cben Y, Xiong DH, Yang TL, Yang F, Jiang H, et al. (2007) Variations in RANK gene are associated with adult height in Caucasians. Am J Hum Biol 19: 559-65.
4. Perola M, Sammalisto S, Hiekkalinna T, Martin NG, Visscher PM, et al. (2007) Combined Genome Scans for Body Stature in 6,602 European Twins: Evidence for Common Caucasian Loci. PLoS Genet 3: e97.
5. Hirschhom JN, Lindgren CM, Daly MJ, Kirby A, Schaffner SF, et al. (2001) Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet 69: 106-16.
6. Perola M, Ohman M, Hiekkalinna T, Leppavuori J, Pajukanta P, et al. (2001) Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups. Am J Hum Genet 69: 117-23.
7. Smith WD, Cunningham DA, Patterson DH, Rechnitzer PA, Koval JJ (1992) Forced expiratory volume, height, and demispan in Canadian men and women aged 55 86. J Gerontol 47: M40-4.
8. Palloni A, Guend A (2005) Stature prediction equations for elderly Hispanics in Latin American countries by sex and ethnic background. J Gerontol A Biol Sci Med Sci 60: 804-10.
9. Parkey JM, Dillard TA, Phillips YY (1996) Arm span-height relationships in patients referred for spirometry. Am J Respir Crit Care Med 154: 533-6.
10. Ritz P (2004) Validity of measuring knee-height as an estimate of height in diseased French elderly persons. J Nutr Health Aging 8: 386-8.
11. Arden NK, Baker J, Hogg C, Baan K, Spector TD (1996) The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J Bone Miner Res 11: 530-4.
12. Deng HW, Xu FH, Liu YZ, Shen H, Deng H et al (2002) A whole-genome linkage scan suggests several genomic regions potentially containing QTLs underlying the variation of stature. Am J Med Genet 113: 29-39.
13. Wu X, Cooper RS, Boerwinkle E, Turner ST, Hunt S, et al. (2003) Combined analysis of genomewide scans for adult height: results from the NHLBI Family Blood Pressure Program. Eur J Hum Genet 11: 271-4.
14. Willemsen G, Boomsma DI, Beem AL, Vink JM, Slagboom PE, et al. (2004)0 QTLs for height: results of a full genome scan in Dutch sibling pairs. Eur J Hum Genet 12: 820-8.
15. Beck SR, Brown WM, Williams AH, Pierce J, Rich SS, et al. (2003) Agestratified QTL genome scan analyses for anthropometric measures. BMC Genet 4 Suppl 1: S31.
16. Niwa T (2007) Protein glutathionylation and oxidative stress. J Chromatogr B Analyt Technol Biomed Life Sci 855: 59-65.
17. Kenchappa RS, Diwakar L, Boyd MR, Ravinchanath V (2002) Thioltransferase (glutaredoxin) mediates recovery of motor neurons from excitotoxic mitochondrial injury. J Neurosci 22: 8402-10.
18. Miller NH, Marosy B, Justice CM, Novak SM, Tang FY, et al. (2006) Linkage analysis of genetic loci for kyphoscoliosis on chromosomes 5p13, 13q13.3, and 13q32. Am J Med Genet A 140: 1059-68.
19. Krishna J, Myers TL, Bourgeois MJ, Took V (1997) Interstitial deletion of long arm of chromosome no. 5 with growth hormone deficiency-an emerging syndrome? Clin Genet 51: 48-51.
20. Martin RB (2002) Size, structure and gender: lessons about fracture risk. J Musculoskelet Neuronal Interact 2: 209-11.
21. Andrew T, Hart DJ, Snieder H, de Lange M, Spector TD, et al. (2001) Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res 4: 464-77.
22. Antoniades L, MacGregor AJ, Andrew T, Spector TD (2003) Association of birth weight with osteoporosis and osteoarthritis in adult twins. Rheumatology 42: 791-6.
23. Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, et al. (2007) A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet 39: 1245-50.
24. Visscher PM, Macgregor S, Benyamin B, Zhu G, Gordon S, et al. (2007) Genome partitioning of genetic variation for height from 11,214 sibling pairs. Am J Hum Genet 81: 1104- 10.
25. Fang Y, van Meurs JB, Rivadeneira F, van Schoor NM, van Leeuwen JP, et al. (2007) Vitamin D receptor gene haplotype is associated with body height and bone size. J Clin Endocrinol Metab 92: 1491-501.
26. Spector TD, MacGregor AJ (2002) The St. Thomas' UK Adult Twin Registry. Twin Res 5: 440-3.
27. Spector TD, Williams FM (2006) The UK Adult Twin Registry (TwimUK). Twin Res Hum Genet 9: 899-906.
28. Chinappen-Horsley U, Blake GM, Fogelman I, Spector TD (2007) A Method for Determining Skeletal Lengths from DXA Images. BMC Musculoskelet Disord 8: 113.
29. Stata Statistical Software [computer program] (2005) Version Release 9. College Station, TX: Stata Corporation.
30. Neale MC, Boker SM, Xie G, Macs HH (2006) Mx: Statistical Modeling. 7th Edition. Richmond VA 23298: Department of Psychiatry.
31. Barber MJ, Cordell HJ, MacGregor AJ, Andrew T (2004) Gamma regression improves Haseman-Elston and variance components linkage analysis for sibpairs. Genet Epidemiol 26: 97-107.
32. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrres. Am J Hum Genet 62: 1198-211.
33. Iturria SJ, Williams JT, Almasy L, Dyer TD, Blangero J (1999) An empirical test of the significance of an observed quantitative trait locus effect that preserves additive genetic variation. Genet Epidemiol 17 Suppl 1: S169-S173.
34. Wilson SG, Reed PW, Andrew T, Barber MJ, Lindersson M, et al. (2004) A genome-screen of a large twin cohort reveals linkage for quantitative ultrasound of the calcaneus to 2q33-37 and 4q12-21. J Bone Miner Res 19: 270-7.