Inhibition of proliferation to omega-3 fatty acids in chemoresistant pancreatic cancer cells: Mechanism of action may be more complex

Annals of Surgical Oncology

Volumn 15, Issue 7, 2008, Pages 2057-

  Persaud, Raj ^a  

^a SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; GEMCITABINE; GUANINE NUCLEOTIDE BINDING PROTEIN; ICOSANOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE; OMEGA 3 FATTY ACID; PROSTAGLANDIN E2; STAT3 PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER INHIBITION; CELL ADHESION; CELL MEMBRANE; CELL PROLIFERATION; DRUG MECHANISM; LETTER; PANCREAS CANCER; SIGNAL TRANSDUCTION;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CELL LINE, TUMOR; DEOXYCYTIDINE; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FATTY ACIDS, OMEGA-3; HUMANS; NF-KAPPA B; PANCREATIC NEOPLASMS; STAT3 TRANSCRIPTION FACTOR;

EID: 46149108575     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-008-9842-0     Document Type: Letter

References (5)

1. Hering J, Garrean S, Dekoj TR, et al. Inhibition of proliferation by omega-3 fatty acids in chemoresistant pancreatic cancer cells Ann Surg Oncol. 2007; 14:3620-8
2. Dekoj T, Lee S, Desai S, et al. G2/M cell-cycle arrest and apoptosis by n-3 fatty acids in a pancreatic cancer model J Surg Res. 2007; 139:106-12
3. Larsson SC, Kumlin M, Ingelman-Sundberg M, et al. Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms Am J Clin Nutr. 2004; 79:935-45
4. Harris WS. Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor Pharmacol Res. 2007; 55:217-23
5. Stehr SN, Heller AR. Omega-3 fatty acid effects on biochemical indices following cancer surgery Clin Chim Acta 2006; 373:1-8