A T-to-G transversion at nucleotide -567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F

Molecular and Cellular Biology

Volumn 28, Issue 13, 2008, Pages 4386-4393

  Chen, Zhiyi ^a   Luo, Hong Yuan ^a   Basran, Raveen K ^a   Hsu, Tien Huei ^a   Mang, Daniel W H ^a   Nuntakarn, Lalana ^a   Rosenfield, Cathy G ^b   Patrinos, George P ^c   Hardison, Ross C ^d   Steinberg, Martin H ^a   Chui, David H K ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA GLOBIN; HEMOGLOBIN F; LUCIFERASE; NUCLEOTIDE; TRANSCRIPTION FACTOR GATA 1;

ADULT; ARTICLE; BETA THALASSEMIA; CASE REPORT; CHILD; DISEASE SEVERITY; ERYTHROID CELL; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSFECTION; HBG2 GENE; HEMOGLOBIN SYNTHESIS; HUMAN; HUMAN CELL; MALE; MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REGULATORY MECHANISM; REPORTER GENE; SICKLE CELL ANEMIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CHILD; FEMALE; FETAL HEMOGLOBIN; GATA1 TRANSCRIPTION FACTOR; GENOME, HUMAN; GLOBINS; GUANINE; HUMANS; MALE; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEOTIDES; PHYLOGENY; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; SEQUENCE ALIGNMENT; SILENCER ELEMENTS, TRANSCRIPTIONAL; THYMINE; TRANSCRIPTION, GENETIC;

PRIMATES; SIMIAE;

EID: 46149098674     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00071-08     Document Type: Article

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