Research on pharmacology, toxicology and safety of Semen Strychni: Review and prospect

Journal of Chinese Integrative Medicine

Volumn 6, Issue 6, 2008, Pages 645-649

  Guo, Zhen Hua ^a   Ma, Hong Mei ^a   Zhang, Bo Li ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Pharmacology; Safety; Semen strychni; Toxicology

Indexed keywords

BRUCINE; CALCIUM ION; NUX VOMICA; POTASSIUM ION; SODIUM ION; STRYCHNINE;

ACTION POTENTIAL; DRUG MECHANISM; DRUG RESEARCH; DRUG SAFETY; LD 50; MUSCLE CONTRACTION; NONHUMAN; REVIEW; TOXICITY TESTING;

ANIMALS; HUMANS; LETHAL DOSE 50; QUALITY CONTROL; SAFETY; SEEDS; STRYCHNINE; STRYCHNOS NUX-VOMICA;

EID: 46049115267     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20080620     Document Type: Review

References (21)

1. Wang QW, Liu L, Huang GZ. Study of toxicology of strychnos. Fa Yi Xue Za Zhi. 2004; 20(3): 183-184. Chinese with abstract in English.
2. 13CNMR of sixteen strychnos alkaloids. Yao Xue Xue Bao. 1994; 29 (1): 44-48. Chinese with abstract in English.
3. Huang XR, Cao D. Research advancement of Semen Strychni. Shanghai Zhong Yi Yao Za Zhi. 2005; 39 (1): 62-65. Chinese with abstract in English.
4. Yin W, Cai BC. Clinical and pharmacology research progress of Semen Strychni. Jiangsu Zhong Yi. 2000; 21(7): 42-44. Chinese.
5. Wei SC, Xu LJ, Zhang XQ. Effect of crude alkaloid of Semen Strychni on adjuvant arthritis in rat. Zhongguo Yao Li Xue Tong Bao. 2001; 17(4): 479-480. Chinese with abstract in English.
6. Zhou AX, Guo SY, Tian JL, et al. Effects of compound prescription Semen Strychni Tablet on immunologic function. Zhongguo Shi Yan Fang Ji Xue Za Zhi. 1998; 4 (4): 46-48. Chinese with abstract in English.
7. Lu YM, Chen L, Cai BC, et al. Single channel analysis and electron micrography study on myocardial effects of isobrucine. Yao Xue Xue Bao. 1995; 30(3): 168-171. Chinese with abstract in English.
8. Li MH, Zhao DH, Zhang GQ. Effect of brucine on the action potentials in guinea pig papillary muscles. Zhongguo Yao Li Xue Bao. 1997; 13 (2): 157-159. Chinese with abstract in English.
9. Lu YM, Chen L, Cai BC, et al. Comparison of brucine and nitrogen oxides isobrucine in their anti-cancer and anti-oxidation effect. Nanjing Zhong Yi Yao Da Xue Xue Bao. 1998; 14(6): 349-351. Chinese with abstract in English.
10. Song AY, Zhang GL, Liu SJ, et al. Experimental research of anti-cancer effect of Semen Strychni. Zhongguo Zhong Yi Yao Ke Ji. 2004; 11 (6): 363. Chinese.
11. 22. Zhongguo Yao Wu Yu Lin Chuang. 1997; 13(2): 157-159. Chinese with abstract in English.
12. Zhang M, Li P, Chen ZH, et al. Effects of brucine on nitric oxide induced apoptosis in chondrocyte. Zhongguo Lin Chuang Kang Fu. 2003; 7 (26): 3554-3555. Chinese with abstract in English.
13. Zhou AX, Yao XZ, Shen H, et al. Analgesia function and toxicology experiment of the compound prescription nux-vomica. Zhongguo Shi Yan Fang Ji Xue Za Zhi. 1998; 4(4): 59-60. Chinese.
14. Zhu JW, Wu JB, Li CS, et al. Study of the analgesia function and pharmacodynamics of brucine. Zhongguo Zhong Yi Yao Ke Ji. 2005; 12(3): 166-167. Chinese.
15. Wu YF, Lin JM, Zheng LP, et al. The effect of strychnos nuxvomica processed in three different ways on blood serum SOD and testosterone in mice. Fujian Zhong Yi Xue Yuan Xue Bao. 2004; 14(2): 24-25. Chinese with abstract in English.
16. Zhao ZD, Huang ZS. Advance in toxic action and side effect of Semen Strychni. Guo Yi Lun Tan. 2003; 18 (1): 50-51. Chinese with abstract in English.
17. Li BJ. One case of dysphrenia caused by poison effect of Semen Strychni. Shannxi Zhong Yi. 1995; 16 (7): 314. Chinese.
18. Wang JZ, Ma XM. Acupuncture and moxibustion in treatment of eight cases of double side facial nerve paralysis caused by poison effect of Semen Strychni. Zhong Yi Yao Xue Bao. 1998; 26(4): 33. Chinese.
19. Han JJ. One case of acute kidney function failure death caused by poison effect of Semen Strychni. Zhong Ri You Hao Yi Yuan Xue Bao. 1999; 13(1): 14. Chinese.
20. Zhao HW, Weng SA, Zhu YN, et al. Effects of brucine on murine lymphocyte functions. Zhongguo Yao Li Xue Tong Bao. 1999; 15 (4): 354-356. Chinese with abstract in English.
21. Yan YS, Zhou L. Brief analysis of the poisoning reason of Semen Strychni. Luzhou Yi Xue Yuan Xue Bao. 2001; 24(4): 276. Chinese.