Effects of cocoa flavanols on risk factors for cardiovascular disease

Asia Pacific Journal of Clinical Nutrition

Volumn 17, Issue SUPPL. 1, 2008, Pages 284-287

  Erdman Jr , John W ^a   Carson, LeaAnn ^a   Kwik Uribe, Catherine ^b   Evans, Ellen M ^a   Allen, Robin R ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b MARS INC   (United States)

Author keywords

Blood pressure; Cardiovascular; Cocoa; Flavanols; Flavonoids

Indexed keywords

THEOBROMA CACAO;

FLAVONOID;

BLOOD PRESSURE; CACAO; CARDIOVASCULAR DISEASE; CHEMISTRY; DRUG EFFECT; HUMAN; PHYSIOLOGY; REVIEW; RISK FACTOR; THROMBOCYTE; VASCULAR ENDOTHELIUM;

BLOOD PLATELETS; BLOOD PRESSURE; CACAO; CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; FLAVONOIDS; HUMANS; RISK FACTORS;

EID: 46049114137     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (18)

1. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, et al. Heart Disease and Stroke Statistics - 2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006;113:e85-151.
2. Organization WH. Cardiovasular Diseases. 2007 [cited; Available from: www.who.int/mediacentre/factsheets
3. Mennen LI, Sapinho D, de Bree A, Arnault N, Bertrais S, Galan P, et al. Consumption of foods rich in flavonoids is related to a decreased cardiovascular risk in apparently healthy French women. J Nutr. 2004;134:923-6.
4. Knekt P, Jarvinen R, Reunanen A, Maatela J. Flavonoid intake and coronary mortality in Finland: a cohort study. Bmj. 1996;312:478-81.
5. Buijsse B, Feskens EJ, Kok FJ, Kromhout D. Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study. Arch Intern Med. 2006;166:411-7.
6. Erdman JW, Jr., Balentine D, Arab L, Beecher G, Dwyer JT, Folts J, et al. Flavonoids and Heart Health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC. J Nutr. 2007;137:718S-37S.
7. Fisher ND, Hughes M, Gerhard-Herman M, Hollenberg NK. Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans. J Hypertens. 2003;21:2281-6.
8. Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, et al. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A. 2006;103:1024-9.
9. Heiss C, Finis D, Kleinbongard P, Hoffmann A, Rassaf T, Kelm M, et al. Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week. J Cardiovasc Pharmacol. 2007;49:74-80.
10. Pearson DA, Paglieroni TG, Rein D, Wun T, Schramm DD, Wang JF, et al. The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function. Thromb Res. 2002 15;106:191-7.
11. Murphy KJ, Chronopoulos AK, Singh I, Francis MA, Moriarty H, Pike MJ, et al. Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. Am J Clin Nutr. 2003;77:1466-73.
12. Grassi D, Necozione S, Lippi C, Croce G, Valeri L, Pasqualetti P, et al. Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension. 2005;46:398-405.
13. Taubert D, Roesen R, Schomig E. Effect of cocoa and tea intake on blood pressure: a meta-analysis. Arch Intern Med. 2007;167:626-34.
14. Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA, et al. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr. 2007;85:895-909.
15. Hollenberg NK, Martinez G, McCullough M, Meinking T, Passan D, Preston M, et al. Aging, acculturation, salt intake, and hypertension in the Kuna of Panama. Hypertension. 1997;29:171-6.
16. Kondo K HR, Matsumoto A, Igarashr O, Ltahura H. Inhibition of LDL oxidation by cocoa. The Lancet. 1996;348:1514.
17. Holt RR, Actis-Goretta L, Momma TY, Keen CL. Dietary flavanols and platelet reactivity. J Cardiovasc Pharmacol. 2006;47 Suppl 2:S187-96; discussion S206-9.
18. Law MR. Plant sterol and stanol margarines and health. West J Med. 2000;173:43-7.