Use of acute hyperphenylalaninemia in rhesus monkeys to examine sensitivity and stability of the L-[1-11C]leucine method for measurement of regional rates of cerebral protein synthesis with PET

Journal of Cerebral Blood Flow and Metabolism

Volumn 28, Issue 7, 2008, Pages 1388-1398

  Smith, Carolyn B ^a   Schmidt, Kathleen C ^a   Bishu, Shrinivas ^a   Channing, Michael A ^b   Bacon, Jeff ^b   Burlin, Thomas V ^a   Qin, Mei ^a   Liu, Zhong Hua ^a   Xia, Zengyan ^a   Huang, Tianjiang ^a   Vuong, Bee Kee ^b   Herscovitch, Peter ^b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Brain; Hyperphenylalaninemia; Leucine; Positron emission tomography; Protein synthesis

Indexed keywords

BRAIN PROTEIN; ISOFLURANE; LEUCINE; LEUCINE 1 C 11; PHENYLALANINE; RADIOPHARMACEUTICAL AGENT;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPERPHENYLALANINEMIA; MALE; NON INVASIVE MEASUREMENT; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RHESUS MONKEY; SENSITIVITY ANALYSIS; STATISTICAL SIGNIFICANCE;

ANIMALS; BRAIN CHEMISTRY; CARBON RADIOISOTOPES; KINETICS; LEUCINE; MACACA MULATTA; METHODS; PHENYLKETONURIAS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BIOSYNTHESIS;

EID: 46049107354     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2008.27     Document Type: Article

References (25)

1. Aoki F, Siegel FL (1970) Hyperphenylalaninemia: disaggregation of brain polyribosomes in young rats. Science 168:129-30
2. 2. J Cereb Blood Flow Metab 7:709-19
3. Carson RE, Barker WC, Liow J-S, Johnson CA (2003) Design of a motion-compensation OSEM list-mode algorithm for resolution-recovery reconstruction for the HRRT. IEEE Nucl Sci Symp Conf Rec 5:3281-5
4. 11C-methionine in phenylketonuria. Eur J Pediatr 136:13-9
5. Dunlop DS, Yang X-R, Lajtha A (1994) The effect of elevated plasma phenylalanine levels on protein synthesis rates in adult rat brain. Biochem J 302:601-10
6. Hughes JV, Johnson TC (1977) The effects of hyperphenylalaninemia on the concentrations of aminoacyl-transfer ribonucleic acid in vivo. Biochem J 162:527-37
7. 15O]water and dynamic positron emission tomography. J Cereb Blood Flow Metab 8:285-8
8. Keen RE, Barrio JR, Huang S-C, Hawkins RA, Phelps ME (1989) In vivo cerebral protein synthesis rates with leucyl-transfer RNA used as a precursor pool: determination of biochemical parameters to structure tracer kinetic models for positron emission tomography. J Cereb Blood Flow Metab 9:425-45
9. Knudsen GM, Hasselbalch S, Toft PB, Christensen E, Paulson OB, Lou H (1995) Blood-brain barrier transport of amino acids in healthy controls and in patients with phenylketonuria. J Inher Metab Dis 18:653-64
10. Patlak CS, Pettigrew KD (1976) A method to obtain infusion schedules for prescribed blood concentration time courses. J Appl Physiol 40:458-63
11. Qin M, Kang J, Burlin T, Smith CB (2005) Post-adolescent changes in regional cerebral protein synthesis: an in vivo study in the Fmr1 null mouse. J Neurosci 25:5087-5095
12. 11C]leucine and PET with correction for recycling of tissue amino acids: I. Kinetic modeling approach. J Cereb Blood Flow Metab 25:617-28
13. Shulkin BL, Betz AL, Koeppe RA, Agranoff BW (1995) Inhibition of neutral amino acid transport across the human blood-brain barrier by phenylalanine. J Neurochem 64:1252-7
14. 2 into the acid-labile, the acid-soluble, the lipid, the protein and the nucleic acid fractions of rat brain tissue. Acta Physiol Scand 64:182-92
15. Smith CB (1991) The measurement of regional rates of cerebral protein synthesis in vivo. Neurochem Res 16:1037-45
16. 11C]leucine in adult monkeys: effects of large neutral amino acid concentrations on parameter estimates. J Nucl Med 48(Suppl 2):238P
17. Smith CB, Deibler GE, Eng N, Schmidt K, Sokoloff L (1988) Measurement of local cerebral protein synthesis in vivo: influence of recycling of amino acids derived from protein degradation. Proc Natl Acad Sci USA 85:9341-9345
18. Smith CB, Kang J (2000) Cerebral protein synthesis in a genetic mouse model of phenylketonuria. Proc Natl Acad Sci USA 97:11014-9
19. Smith CB, Schmidt KC, Bacon J, Bishu S, Burlin T, Channing M, Herscovitch P, Huang T, Liu Z-H, Qin M, Vuong B-K, Xia Z (2007a) Effects of hyperphenylalaninemia on PET measurement of regional rates of cerebral protein synthesis with correction for recycling in adult monkeys. J Cereb Blood Flow Metab 27(Suppl 1) (XXIII-1): P02-5U
20. 11C]leucine and PETwith correction for recycling of tissue amino acids: II. Validation in rhesus monkeys. J Cerebr Blood Flow Metab 25:629-640
21. Smith QR, Momma S, Aoyagi M, Rapoport SI (1987) Kinetics of neutral amino acid transport across the blood-brain barrier. J Neurochem 49:1651-8
22. Studenov AR, Szalda DE, Ding YS (2003) Synthesis of no-carrier added C-11 labeled D- and L-enantiomers of phenylalanine and tyrosine for comparative PET studies. Nuc Med Biol 30:39-44
23. Taub F, Johnson TC (1975) The mechanism of polyribosome disaggregation in brain tissue by phenylalanine. Biochem J 151:173-80
24. Wienhard K, Schmand M, Casey ME, Baker K, Bao J, Eriksson L, Jones WF, Knoess C, Lenox M, Lercher M, Luk P, Michel C, Reed JH, Richerzhagen N, Treffert J, Vollmar S, Young JW, Heiss WD, Nutt R (2002) The ECAT HRRT: performance and first clinical application of the new high resolution research tomograph. IEEE Trans Nucl Sci 49:104-10
25. Woods RP, Mazziotta JC, Cherry SR (1993) MRI-PET registration with automated algorithm. J Comput Assist Tomogr 17:536-46