Hereditary diffuse gastric cancer: Diagnosis, genetic counseling, and prophylactic total gastrectomy

Cancer

Volumn 112, Issue 12, 2008, Pages 2655-2663

  Lynch, Henry T ^a   Kaurah, Pardeep ^b   Wirtzfeld, Debrah ^c   Rubinstein, Wendy S ^d   Weissman, Scott ^d   Lynch, Jane F ^a   Grady, William ^e   Wiyrick, Sara ^f   Senz, Janine ^b   Huntsman, David G ^b  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^d Center for Medical Genetics   (United States)

^e Fred Hutchinson Cancer Research Center   (United States)

^f UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

Diffuse gastric cancer; Family pedigree; Hereditary; Prophylactic total gastrectomy; Type E cadherin (epithelial) gene

Indexed keywords

UVOMORULIN; CADHERIN;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER PREVENTION; CANCER SCREENING; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILIAL CANCER; FAMILY STUDY; FEMALE; FOLLOW UP; GENE MUTATION; GENETIC COUNSELING; HETEROZYGOTE DETECTION; HUMAN; MALE; PEDIGREE; PRIORITY JOURNAL; STOMACH CANCER; TOTAL STOMACH RESECTION; COHORT ANALYSIS; GASTRECTOMY; GENETICS; HETEROZYGOTE; MIDDLE AGED; MUTATION; PSYCHOLOGICAL ASPECT; STOMACH TUMOR;

ADULT; AGED; CADHERINS; COHORT STUDIES; FEMALE; GASTRECTOMY; GENETIC COUNSELING; HETEROZYGOTE; HUMANS; MALE; MIDDLE AGED; MUTATION; PEDIGREE; STOMACH NEOPLASMS;

EID: 46049106796     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.23501     Document Type: Article

References (18)

1. Alberts SR, Cervantes A, van De Velde CJ. Gastric cancer: epidemiology, pathology and treatment. Ann Oncol. 2003;14(suppl 2):ii31-ii36.
2. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma: an attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 1965;64:31-49.
3. Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol. 2006;12:354-362.
4. Guilford P, Hopkins J, Harraway J, et al. E-cadherin germline mutations in familial gastric cancer. Nature. 1998;392:402-405.
5. Lynch HT, Grady W, Suriano G, Huntsman D. Gastric cancer: new genetic developments. J Surg Oncol. 2005;90:114-133.
6. Suriano G, Yew S, Ferreira P, et al. Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical management. Clin Cancer Res. 2005;11:5401-5409.
7. Suriano G, Oliveira C, Ferreira P, et al. Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Hum Mol Genet. 2003;12:575-582.
8. Kaurah P, MacMillan A, Boyd N, et al. Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA. 2007;297:2360-2372.
9. Keller G, Vogelsang H, Becker I, et al. Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation. Am J Pathol. 1999;155:337-342.
10. Oliveira C, Seruca R, Caldas C. Genetic screening for hereditary diffuse gastric cancer. Expert Rev Mol Diagn. 2003;3:201-215.
11. Caldas C, Carneiro F, Lynch HT, et al. Familial gastric cancer: overview and guidelines for management. J Med Genet. 1999;36:873-880.
12. Bacani JT, Soares M, Zwingerman R, et al. CDH1/E-cadherin germline mutations in early onset gastric cancer. J Med Genet. 2006;43:867-872.
13. Norton JA, Ham CM, Van Dam J, et al. CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer. Ann Surg. 2007;245:873-879.
14. Lynch HT, Grady W, Lynch JF, Tsuchiya KD, Wiesner G, Markowitz SD. E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma. Cancer Genet Cytogenet. 2000;122:1-6.
15. Lynch HT. Family Information Service and hereditary cancer. Cancer. 2001;91:625-628.
16. Chung DC, Yoon SS, Lauwers GY, Patel D. Case 22-2007: a woman with a family history of gastric and breast cancer. N Engl J Med. 2007;357:283-291.
17. Brooks-Wilson AR, Kaurah P, Suriano G, et al. Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria. J Med Genet. 2004;41:508-517.
18. MacDonald DJ, Lessick M. Hereditary cancers in children and ethical and psychosocial implications. J Pediatr Nurs. 2000;15:217-225.