Usefulness of combination treatment using allopurinol and benzbromarone for gout and hyperuricemia accompanying renal dysfunction: Kinetic analysis of oxypurinol

Japanese Journal of Nephrology

Volumn 50, Issue 4, 2008, Pages 506-512

  Ohno, Iwao ^a   Okabe, Hideaki ^c   Yamaguchi, Yuichiro ^c   Saikawa, Hajime ^c   Uetake, Daijiro ^c   Hikita, Miho ^c   Gomi, Hideho ^c   Ichida, Kimiyoshi ^b   Hosoya, Tatsuo ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c NONE

Author keywords

Allopurinol; Benzbromarone; Gout; Oxypurinol; Renal dysfunction

Indexed keywords

ALLOPURINOL; BENZBROMARONE; HYPOXANTHINE; OXIPURINOL; XANTHINE;

ADULT; ARTICLE; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE CLEARANCE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; GOUT; HUMAN; HYPERURICEMIA; KIDNEY DYSFUNCTION; MALE; MONOTHERAPY; URIC ACID BLOOD LEVEL; URIC ACID URINE LEVEL;

ADULT; AGED; AGED, 80 AND OVER; ALLOPURINOL; BENZBROMARONE; DRUG THERAPY, COMBINATION; GOUT; GOUT SUPPRESSANTS; HUMANS; HYPERURICEMIA; KIDNEY DISEASES; MALE; MIDDLE AGED; OXYPURINOL; RETROSPECTIVE STUDIES;

EID: 46049097939     PISSN: 03852385     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Elion GB, Yu TF, Gutman AB, Hitchings GH. Renal clearance of oxipurinol, the chief metabolite of allopurinol. Am J Med 1968 ; 45 : 69-77.
2. Hande KR, Noone RM, Stone WJ. Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency. Am J Med 1984 ; 76 : 47-56.
3. Japanese source
4. Muller FO, Schall R, Groenewoud G, Hundt HK, van der Merwe JC, van Dyk M. The effect of benzbromarone on allopurinol/oxypurinol kinetics in patients with gout. Eur J Clin Pharmacol 1993 ; 44 : 69-72.
5. Hosoya T, Ichida K, Tabe A, Sakai O. Combined therapy using allopurinol and benzbromarone for gout and hyperuricemia complicated with renal disorder. Jpn J Rheumatol 1992 ; 4 : 77-90.
6. Ichida K, Amaya Y, Kamatani N, Nishino T, Hosoya T, Sakai O. Identification of two mutations in human xanthine dehydrogenase gene responsible for classical type I xanthinuria. J Clin Invest 1997 ; 99 : 2391-2397.
7. Japanese source
8. Simmonds HA, Cameron JS, Morris GS, Davies PM. Allopurinol in renal failure and the tumor lysis syndrome. Clin Chim Acta 1986 ; 160 : 189-195.
9. Japanese source