Severe drug hypersensitivity reaction in a young woman treated with doxycycline

Dermatology

Volumn 217, Issue 1, 2008, Pages 23-26

  Robles, David T ^a   Leonard, Jennifer L ^a   Compton, Nicholas ^a   Waghmare, Alpana ^a   McDonough, Karen A ^a   George, Evan ^a   Wolgamot, Greg ^a   Fleckman, Philip ^a  

^a UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

Doxycycline; DRESS syndrome; Drug rash; Hypersensitivity syndrome

Indexed keywords

DOXYCYCLINE; METHYLPREDNISOLONE; PREDNISONE;

ACNE VULGARIS; ADULT; ARTICLE; BRONCHOSCOPY; CASE REPORT; DRESS SYNDROME; DRUG EXPOSURE; EXTRAVASATION; FACE EDEMA; FEMALE; FEVER; GENE REARRANGEMENT; HEPATITIS; HEPATOSPLENOMEGALY; HUMAN; HYPERSENSITIVITY REACTION; IMMUNOFLUORESCENCE; LYMPHADENOPATHY; MORTALITY; NEPHRITIS; PAPULAR RASH; PNEUMONIA; PRIORITY JOURNAL; PRURITUS; RESPIRATORY FAILURE; TRANSTHORACIC ECHOCARDIOGRAPHY;

ACNE VULGARIS; ADULT; ANTI-BACTERIAL AGENTS; DOXYCYCLINE; DRUG HYPERSENSITIVITY; EDEMA; EOSINOPHILIA; FEMALE; HEPATITIS; HUMANS; LYMPHATIC DISEASES; NEPHRITIS; PNEUMONIA; RESPIRATORY INSUFFICIENCY; SKIN; SYNDROME;

EID: 46049091775     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000119753     Document Type: Article

References (28)

1. Pawin H, Chivot M, Beylot C, Faure M, Poli F, Revuz J, Dreno B: Living with acne. A study of adolescents' personal experiences. Dermatology 2007;215:308-314.
2. Akcam FZ, Aygun FO, Akkaya VB: DRESS like severe drug rash with eosinophilia, atypic lymphocytosis and fever secondary to ceftriaxone. J Infect 2006;53:e51-e53.
3. Roujeau JC: Clinical heterogeneity of drug hypersensitivity. Toxicology 2005;209:123-129.
4. Sapadin AN, Fleischmajer R: Tetracyclines: nonantibiotic properties and their clinical implications. J Am Acad Dermatol 2006;54:258-265.
5. Smilack JD: The tetracyclines. Mayo Clin Proc 1999;74:727-729.
6. Shapiro LE, Knowles SR, Shear NH: Comparative safety of tetracycline, minocycline, and doxycycline. Arch Dermatol 1997;133:1224-1230.
7. Knowles SR, Shapiro L, Shear NH: Serious adverse reactions induced by minocycline. Report of 13 patients and review of the literature. Arch Dermatol 1996;132:934-939.
8. Toyoshima M, Sato A, Hayakawa H, Taniguchi M, Imokawa S, Chida K: A clinical study of minocycline-induced pneumonitis. Intern Med 1996;35:176-179.
9. Curley RK, Verbov JL: Stevens-Johnson syndrome due to tetracyclines - a case report (doxycycline) and review of the literature. Clin Exp Dermatol 1987;12:124-125.
10. Trueb RM, Burg G: Acute generalized exanthematous pustulosis due to doxycycline. Dermatology 1993;186:75-78.
11. Cac N, Messingham MJ, Sniezek PJ, Walling HW: Stevens-Johnson syndrome induced by doxycycline. Cutis 2007;79:119-122.
12. Sullivan JR, Shear NH: The drug hypersensitivity syndrome: what is the pathogenesis? Arch Dermatol 2001;137:357-364.
13. Saivin S, Houin G: Clinical pharmacokinetics of doxycycline and minocycline. Clin Pharmacokinet 1988;15:355-366.
14. Bocker R, Estler CJ, Weber A: Metabolism of doxycycline. Lancet 1982;2:1155.
15. Lee AY, Kim MJ, Chey WY, Choi J, Kim BG: Genetic polymorphism of cytochrome p450 2c9 in diphenylhydantoin-induced cutaneous adverse drug reactions. Eur J Clin Pharmacol 2004;60:155-159.
16. Ates NA, Tursen U, Tamer L, Kanik A, Derici E, Ercan B, Atik U: Glutathione s-transferase polymorphisms in patients with drug eruption. Arch Dermatol Res 2004;295:429-433.
17. Ohtani T, Hiroi A, Sakurane M, Furukawa F: Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine. Br J Dermatol 2003;148:1035-1039.
18. Markel A: Allopurinol-induced dress syndrome. Isr Med Assoc J 2005;7:656-660.
19. Rieder MJ, Shear NH, Kanee A, Tang BK, Spielberg SP: Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity reactions. Clin Pharmacol Ther 1991;49:13-17.
20. Muller P, Dubreil P, Mahe A, Lamaury I, Salzer B, Deloumeaux J, Strobel M: Drug hypersensitivity syndrome in a West-Indian population. Eur J Dermatol 2003;13:478-481.
21. Gennis MA, Vemuri R, Burns EA, Hill JV, Miller MA, Spielberg SP: Familial occurrence of hypersensitivity to phenytoin. Am J Med 1991;91:631-634.
22. Rzany B, Correia O, Kelly JP, Naldi L, Auquier A, Stern R: Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis during first weeks of antiepileptic therapy: a case-control study. Study group of the international case control study on severe cutaneous adverse reactions. Lancet 1999;353:2190-2194.
23. Hamer HM, Morris HH: Hypersensitivity syndrome to antiepileptic drugs: a review including new anticonvulsants. Cleve Clin J Med 1999;66:239-245.
24. Turner RB, Kim CC, Streams BN, Culpepper K, Haynes HA: Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms. J Am Acad Dermatol 2004;50(suppl):S86-S89.
25. Allam JP, Paus T, Reichel C, Bieber T, Novak N: DRESS syndrome associated with carbamazepine and phenytoin. Eur J Dermatol 2004;14:339-342.
26. Tham SN, Kwok YK, Chan HL: Cross-reactivity in fixed drug eruptions to tetracyclines. Arch Dermatol 1996;132:1134-1135.
27. Tigecycline (Tygacil). Obstet Gynecol 2006;107:178-180.
28. Garcia-Doval I, LeCleach L, Bocquet H, Otero XL, Roujeau JC: Toxic epidermal necrolysis and Stevens-Johnson syndrome: does early withdrawal of causative drugs decrease the risk of death? Arch Dermatol 2000;136:323-327.