Effect of Echinacea augustifolia extract on cell viability and differentiation in mammary epithelial cells

Phytomedicine

Volumn 15, Issue 8, 2008, Pages 555-562

  Starvaggi Cucuzza, L ^a   Motta, M ^a   Accornero, P ^a   Baratta, M ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Cell viability; Differentiation; Echinacea; Mammary epithelium

Indexed keywords

BETA CASEIN; CASPASE 3; ECHINACEA ANGUSTIFLORA EXTRACT; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SOMATOMEDIN;

ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; CELL DIFFERENTIATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CASEINS; CASPASE 3; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ECHINACEA; ENZYME ACTIVATION; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; MAMMARY GLANDS, ANIMAL; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT;

BOVINAE; ECHINACEA ANGUSTIFOLIA;

EID: 46049088709     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2008.02.016     Document Type: Article

References (31)

1. Baratta M., Grolli S., Poletti A., Ramoni R., Motta M., and Tamanini C. Role of androgens in proliferation and differentiation of mouse mammary epithelial cell line HC11. J. Endocrinol. 167 (2000) 53-60
2. Barnes J., Anderson L.A., Gibbons S., and Phillipson J.D. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. J. Pharm. Pharmacol. 57 (2005) 929-954
3. Bauer R. New knowledge regarding the effect and effectiveness of Echinacea purpurea extracts. Wien. Med. Wochenschr. 152 (2002) 407-411
4. Bauer R., Remiger P., and Wagner H. New alkamides from Echinacea angustifolia and E. purpurea roots. Planta Med. 54 (1988) 563-564
5. Bernstein B.J., and Grasso T. Prevalence of complementary and alternative medicine use in cancer patients. Oncology (Williston. Park) 15 (2001) 1267-1272
6. Chicca A., Adinolfi B., Martinotti E., Fogli S., Breschi M.C., Pellati F., Benvenuti S., and Nieri P. Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines. J. Ethnopharmacol. 110 (2007) 148-153
7. Coeugniet E.G., and Elek E. Immunomodulation with Viscum album and Echinacea purpurea extracts. Onkologie 10 (1987) 27-33
8. Cohen G.M. Caspases: the executioners of apoptosis. Biochem. J. 326 Part 1 (1997) 1-16
9. Di Carlo G., Nuzzo I., Capasso R., Sanges M.R., Galdiero E., Capasso F., and Carratelli C.R. Modulation of apoptosis in mice treated with Echinacea and St. John's Wort. Pharmacol. Res. 48 (2003) 273-277
10. Di Carlo C.G., Pacilio M., Capasso R., and Di C.R. Effect on prolactin secretion of Echinacea purpurea, Hypericum perforatum and Eleutherococcus senticosus. Phytomedicine 12 (2005) 644-647
11. Ernst E. The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava. Ann. Intern. Med. 136 (2002) 42-53
12. Estrov Z., Shishodia S., Faderl S., Harris D., Van Q., Kantarjian H.M., Talpaz M., and Aggarwal B.B. Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 102 (2003) 987-995
13. Hermisson M., Wagenknecht B., Wolburg H., Glaser T., Dichgans J., and Weller M. Sensitization to CD95 ligand-induced apoptosis in human glioma cells by hyperthermia involves enhanced cytochrome c release. Oncogene 19 (2000) 2338-2345
14. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
15. Luettig B., Steinmuller C., Gifford G.E., Wagner H., and Lohmann-Matthes M.L. Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J. Natl. Cancer Inst. 81 (1989) 669-675
16. Luschen S., Scherer G., Ussat S., Ungefroren H., and dam-Klages S. Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-kappaB, elicits caspase activity, and enhances cytotoxicity. Exp. Cell Res. 293 (2004) 196-206
17. Marte B.M., Jeschke M., Graus-Porta D., Taverna D., Hofer P., Groner B., Yarden Y., and Hynes N.E. Neu differentiation factor/heregulin modulates growth and differentiation of HC11 mammary epithelial cells. Mol. Endocrinol. 9 (1995) 14-23
18. Nieri P., Adinolfi B., Morelli I., Breschi M.C., Simoni G., and Martinotti E. Genetic characterization of the three medicinal Echinacea species using RAPD analysis. Planta Med. 69 (2003) 685-686
19. Rininger J.A., Kickner S., Chigurupati P., McLean A., and Franck Z. Immunopharmacological activity of Echinacea preparations following simulated digestion on murine macrophages and human peripheral blood mononuclear cells. J. Leukoc. Biol. 68 (2000) 503-510
20. Roesler J., Emmendorffer A., Steinmuller C., Luettig B., Wagner H., and Lohmann-Matthes M.L. Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to test subjects mediates activation of the phagocyte system. Int. J. Immunopharmacol. 13 (1991) 931-941
21. Roesler J., Steinmuller C., Kiderlen A., Emmendorffer A., Wagner H., and Lohmann-Matthes M.L. Application of purified polysaccharides from cell cultures of the plant Echinacea purpurea to mice mediates protection against systemic infections with Listeria monocytogenes and Candida albicans. Int. J. Immunopharmacol. 13 (1991) 27-37
22. See D.M., Broumand N., Sahl L., and Tilles J.G. In vitro effects of Echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacology 35 (1997) 229-235
23. Seger R., and Krebs E.G. The MAPK signaling cascade. FASEB J. 9 (1995) 726-735
24. Sharma M., Arnason J.T., Burt A., and Hudson J.B. Echinacea extracts modulate the pattern of chemokine and cytokine secretion in rhinovirus-infected and uninfected epithelial cells. Phytother. Res. 20 (2006) 147-152
25. Sharma M., Arnason J.T., and Hudson J.B. Echinacea extracts modulate the production of multiple transcription factors in uninfected cells and rhinovirus-infected cells. Phytother. Res. 20 (2006) 1074-1079
26. Sparreboom A., Cox M.C., Acharya M.R., and Figg W.D. Herbal remedies in the United States: potential adverse interactions with anticancer agents. J. Clin. Oncol. 22 (2004) 2489-2503
27. Steinmuller C., Roesler J., Grottrup E., Franke G., Wagner H., and Lohmann-Matthes M.L. Polysaccharides isolated from plant cell cultures of Echinacea purpurea enhance the resistance of immunosuppressed mice against systemic infections with Candida albicans and Listeria monocytogenes. Int. J. Immunopharmacol. 15 (1993) 605-614
28. Stimpel M., Proksch A., Wagner H., and Lohmann-Matthes M.L. Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea. Infect. Immun. 46 (1984) 845-849
29. Wagner H., Stuppner H., Puhlmann J., Jurcic K., Zenk M.H., and Lohmann-Matthes M.L. Immunologically active polysaccharides from tissue cultures of Echinacea purpurea. Planta Med. 52 (1986) 428
30. Wang C.Y., Chiao M.T., Yen P.J., Huang W.C., Hou C.C., Chien S.C., Yeh K.C., Yang W.C., Shyur L.F., and Yang N.S. Modulatory effects of Echinacea purpurea extracts on human dendritic cells: a cell- and gene-based study. Genomics 88 (2006) 801-808
31. Zhou H.Y., and Wong A.S. Activation of p70S6 K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells. Endocrinology 147 (2006) 2557-2566