Marek's disease vaccines: A solution for today but a worry for tomorrow?

Vaccine

Volumn 26, Issue SUPPL. 3, 2008, Pages

  Gimeno, Isabel M ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Marek's disease; Vaccines; Virulence

Indexed keywords

DNA VACCINE; HERPES VACCINE; IMMUNOLOGICAL ADJUVANT; MAREK DISEASE VACCINE; RECOMBINANT VACCINE;

ARTICLE; BIRD DISEASE; COMBINATION CHEMOTHERAPY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; GENETIC RESISTANCE; INNATE IMMUNITY; MARDIVIRUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; VIRUS STRAIN; VIRUS VIRULENCE;

ANIMALS; CHICKENS; EVOLUTION, MOLECULAR; HERPESVIRUS 2, GALLID; MAREK DISEASE; MAREK DISEASE VACCINES; POULTRY DISEASES; VACCINATION; VIRULENCE;

EID: 46049086747     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.04.009     Document Type: Article

References (150)

1. Churchill A.E. Herpes-type virus isolated in cell culture from tumors of chickens with Marek's disease. I. Studies in cell culture. J Natl Cancer Inst 41 (1968) 939-950
2. Biggs P.M., Churchill A.E., Rootes D.G., and Chubb R.C. The etiology of Marek's disease-an oncogenic herpes-type virus. Perspect Virol 6 (1968) 211-237
3. Shek W.R., Calnek B.W., Schat K.A., and Chen C.L.H. Characterization of Marek's disease virus-infected lymphocytes: discrimination between cytolytically and latently infected cells. J Natl Cancer Inst 70 (1983) 485-491
4. Jones D., Lee L.F., Liu J.L., Kung H.J., and Tillotson J.K. Marek disease virus encodes a basic-Leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors. Proc Natl Acad Sci USA 89 (1992) 4042-4046
5. Sevoian M., Chamberlain D.M., and Counter F.T. Avian lymphomatosis. I. Experimental reproduction of the neural and visceral forms. Vet Med 57 (1962) 500-501
6. Biggs P.M., and Payne L.N. Transmission experiments with Marek's disease (fowl paralysis). Vet Rec 75 (1963) 177-179
7. Biggs P.M., and Payne L.N. Studies on Marek's disease. I. Experimental transmission. J Natl Cancer Inst 39 (1967) 267-280
8. Buckmaster A.E., Scott S.D., Sanderson M.J., Boursnell M.E.G., Ross L.J.N., and Binns M.M. Gene sequence and mapping data from Marek's disease virus and herpesvirus of turkeys: implications for herpesvirus classification. J Gen Virol 69 (1988) 2033-2042
9. Lee L.F., Wu P., Sui D., Ren D., Kamil J., Kung H.-J., et al. The complete unique long sequence and the overall genomic organization of the GA strain of Marek's disease virus. PNAS 97 11 (2000) 6091-6096
10. Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., and Kutish G.F. The genome of a very virulent Marek's disease virus. J Virol 74 17 (2000) 7980-7988
11. Osterrieder N., and Vautherot J.F. The genome content of Marek's disease-like viruses. In: Davison F., and Nair V. (Eds). Marek's disease: an evolving problem (2004), Elsevier, Compton 17-29
12. Churchill A.E., Payne L.N., and Chubb R.C. Immunization against Marek's disease using a live attenuated virus. Nature 221 (1969) 744-747
13. Witter R.L. Increased virulence of Marek's disease virus field isolates. Avian Dis 41 1 (1997) 149-163
14. Marek J. Multiple nervenentzündung (polyneuritis) bei hühnern. Dtsch Tierarztl Wochenschr 15 (1907) 417-421
15. Van der Walle N., and Winkler-Junius E. De Neuritis-episectic bij kippen te Barnveld in 1921. Gezendhleer 10 (1924) 34-49
16. Kaupp B.F. Paralysis of the domestic fowl. Am Assoc Instr Invest Poult Husbandry 7 (1921) 25-31
17. Pappenheimer A.M., Dunn L.C., and Cone V. A study of fowl paralysis: neuro-lymphomatosis gallinarum. Storrs Agric Exp Stn 143 (1926) 187-290
18. Pappenheimer A.M., Dunn L.C., and Cone V. Studies on fowl paralysis (neurolymphomatosis gallinarum). I. Clinical features and pathology. J Exp Med 49 (1929) 63-86
19. Benton W.J., and Cover M.S. The increased incidence of visceral lymphomatosis in broiler and replacement birds. Avian Dis 1 (1957) 320-327
20. Witter R.L., Sharma J.M., and Offenbecker L. Turkey herpesvirus infection in chickens: induction of lymphoproliferative lesions and characterization of vaccinal immunity against Marek's disease. Avian Dis 20 (1976) 676-692
21. Eidson C.S., Page R.K., and Kleven S.H. Effectiveness of cell-free or cell-associated turkey herpesvirus vaccine against Marek's disease in chickens as influenced by maternal antibody, vaccine dose, and time of exposure to Marek's disease virus. Avian Dis 22 (1978) 583-597
22. Witter R.L., Sharma J.M., and Fadly A.M. Pathogenicity of variant Marek's disease virus isolants in vaccinated and unvaccinated chickens. Avian Dis 24 (1980) 210-232
23. Witter R.L., Calnek B.W., Buscaglia C., Gimeno I.M., and Schat K.A. Classification of Marek's disease viruses according to pathotype: philosophy and methodology. Avian Pathol 34 2 (2005) 75-90
24. Dudnikova E., Norkina S., Vlasov A., Slobodchuk A., Lee L.F., and Witter R.L. Evaluation of Marek's disease field isolates by the "best fit" pathotyping assay. Avian Pathol 36 2 (2007) 135-143
25. Kross I. Isolation of highly lytic serotype 1 Marek's disease viruses from recent field outbreaks in Europe. In: Silva R.F., Cheng H.H., Coussens P.M., Lee L.F., and Velicer L.F. (Eds). Current research on Marek's disease (1996), American Association of Avian Pathologists Inc., Kennett Square, PA 113-118
26. Venugopal K., Bland A.P., Ross L.J.N., and Payne L.N. Pathogenicity of an unusual highly virulent Marek's disease virus isolated in the United Kingdom. In: Silva R.F., Cheng H.H., Coussens P.M., Lee L.F., and Velicer L.F. (Eds). Current research on Marek's disease (1996), American Association of Avian Pathologists, Kennett Square, PA 119-124
27. Gimeno I.M., Witter R.L., and Neumann U. Neuropathotyping: a new system to classify Marek's disease virus. Avian Dis 46 4 (2002) 909-918
28. Calnek B.W., Harris R.W., Buscaglia C., Schat K.A., and Lucio B. Relationship between the immunosuppressive potential and the pathotype of Marek's disease virus isolates. Avian Dis 42 1 (1998) 124-132
29. Barrow A., Burgess S.C., Baigent S.J., Howes K., and Nair V.K. Infection of macrophages by a lymphotropic herpesvirus: a new tropism for Marek's disease virus. J Gen Virol 84 (2003) 2635-2645
30. Gimeno I.M., Witter R.L., Hunt H.D., Lee L.F., Reddy S.M., and Neumann U. Marek's disease virus infection in the brain: virus replication, cellular infiltration and major histocompatibility complex antigen expression. Vet Pathol 38 5 (2001) 491-503
31. Rosenberger J.K. Control of Marek's disease. Vineland Update 52 (1995) 1-4
32. Yunis R., Jarosinski K.W., and Schat K.A. Association between rate of viral genome replication and virulence of Marek's disease herpesvirus strains. Virology 328 (2004) 142-150
33. Majerciak V., Geerligs H., Szabová D., and Zelnik V. Identification of virulencerelated Marek's disease virus-specific transcripts by subtractive hybridization. In: Schat K.A., Morgan R.W., Parcells M.S., and Spencer J.L. (Eds). Proceedings of the 6th international symposium on Marek's disease. American Association of Avian Pathologists Kennett Square, PA (2001) 225-231
34. Shamblin C.E., Greene N., Arumugaswami V., Dienglewicz R.L., and Parcells M.S. Comparative analysis of Marek's disease virus (MDV) glycoprotein-, lytic antigen pp38- and transformation antigen Meq-encoding genes: association of meq mutations with MDVs of high virulence. Vet Microbiol 102 (2004) 147-167
35. Silva RF, Lupiani B, Reddy SM. The effect of deleting or inverting the 132 base pair repeats in a pathogenic MDV. Workshop on molecular pathogenesis of Marek's disease and Avian Immunology; 2002, 49.
36. Lupiani B., Silva R.F., Lee L.F., and Reddy S.M. Characterization of the Uss/TRrs junction region of different MDV pathotypes. In: Schat K.A., Morgan R.W., Parcells M.S., and Spencer J.L. (Eds). Proceedings of the 6th international symposium on Marek's disease (2001), American Association of Avian Pathologists, Kennett Square, PA 51-53
37. Silva R.F. Differentiation of pathogenic and non-pathogenic serotype 1 Marek's disease viruses (MDVs) by the polymerase chain reaction amplification of the tandem direct repeats within the MDV genome. Avian Dis 36 (1992) 521-528
38. Spatz S.J., Petherbridge L., Zhao Y., and Nair V. Comparative full-length sequence analysis of oncogenic and vaccine (Rispens) strains of Marek's disease virus. J Gen Virol 88 (2007) 1080-1096
39. Spatz S.J., and Silva R.F. Polymorphisms in the repeat long regions of oncogenic and attenuated pathotypes of Marek's disease virus 1. Virus Genes 35 (2007) 41-53
40. Lee S.I., Takagi M., Ohashi K., Sugimoto C., and Onuma M. Difference in the meq gene between oncogenic and attenuated strains of Marek's disease virus serotype 1. J Vet Med Sci 62 (2000) 287-292
41. Schat K.A., and Baranowski E. Animal vaccination and the evolution of viral pathogens. Rev Sci Tech Off Int Epiz 26 2 (2007) 327-338
42. Gandon S., Mackinnon M.J., Nee S., and Read A.F. Imperfect vaccines and the evolution of pathogen virulence. Nature 414 (2001) 751-756
43. Mackinnon M.J., and Read A.F. Immunity promotes virulence evolution in a malaria model. PLoS Biol 2 9 (2004) e230
44. van Boven M., Mooi F.R., Schellekens J.F.P., Melker H.E., and Kretzschmar M. Pathogen adaptation under imperfect vaccination: implications for pertussies. Proc. Biol. Sci. 272 (2005) 1617-1624
45. Gimeno I.M. Future strategies for controlling Marek's disease. In: Nair V., and Davison F. (Eds). Marek's disease (2004), Elsevier, Oxford 186-198
46. Witter R.L. Current and future strategies for control of Marek's disease. In: Fadly A.M., Schat K.A., and Spencer J.L. (Eds). Diagnosis and control of neoplastic diseases of poultry (1997), American Association of Avian Pathologists, Kennett Square 42-47
47. Witter R.L., and Schat K.A. Marek's disease. In: Saif Y.M., Barnes H.J., Fadly A.M., Glisson J.R., McDougald L.R., and Swayne D.E. (Eds). Diseases of poultry (2003), Iowa State University Press, Ames 407-465
48. Calnek B.W. Pathogenesis of Marek's disease virus infection. In: Hirai K. (Ed). Current topics in microbiology and immunology (2001), Springer-Verlag, Berlin 25-56
49. Jarosinski K.W., Tischer B.K., Trapp S., and Osterrieder N. Marek's disease virus: lytic replication, oncogenesis and control. Expert Rev Vaccines 5 6 (2006) 761-772
50. Osterrieder N., Kamil J.P., Schumacher D., Tischer B.K., and Trapp S. Marek's disease virus: from miasma to model. Nat Rev Microbiol 4 4 (2006) 283-294
51. Adldinger H.K., and Calnek B.W. Effect of chelators on in vitro infection with Marek's disease virus. In: Biggs P.M., de-The G., and Payne L.N. (Eds). Oncogenesis and herpesviruses (1972), International Agency for Research on Cancer, Lyon 99-105
52. Phillips P.A., and Biggs P.M. Course of infection in tissue of susceptible chickens after exposure to strains of Marek's disease and turkey herpesvirus. J Natl Cancer Inst 49 (1972) 1367-1373
53. Purchase H.G. Virus-specific immunofluorescent and precipitin antigens and cell-free virus in the tissues of birds infected with Marek's disease. Cancer Res 30 (1970) 1898-1908
54. Jeurissen S.H.M., Janse E.M., Wagenaar F., and de Boer G.F. The role of splenic ellipsoid-associated reticulum cells in the pathogenesis of Marek's disease. Proceedings of the 4th international symposium on Marek's disease, 19th World's Poultry Congress, vol. 1. World's Poultry Science Association, Amsterdam (1992) 211-215
55. Shek W.R., Schat K.A., and Calnek B.W. Characterization of non-oncogenic Marek's disease virus-infected and turkey herpesvirus infected lymphocytes. J Gen Virol 63 (1982) 333-341
56. Calnek B.W., Schat K.A., Ross L.J.N., and Chen C.L.H. Further characterization of Marek's disease virus infected lymphocytes. II. In vitro infection. Int J Cancer 33 (1984) 399-406
57. Calnek B.W., Schat K.A., Ross L.J.N., Shek W.R., and Chen C.L.H. Further characterization of Marek's disease virus infected lymphocytes. I. In vivo infection. Int J Cancer 33 (1984) 389-398
58. Barrow A.D., Burgess S.C., and Venugopal K. Invasion of avian macrophages by highly virulent Marek's disease virus strain c12/130 represents a "tropic shift" in the pathogenesis. In: Schat K.A., Morgan R.W., Parcells M.S., and Spencer J.L. (Eds). Proceedings of the 6th international symposium on Marek's disease. American Association of Avian Pathologists, New Bolton Center, PA (2001) 63-67
59. Barrow A., and Venugopal K. Molecular characteristics of very virulent European MDV isolates. Acta Virol 43 (1999) 90-93
60. Gimeno I.M., and Silva R.F. Pathogenesis of MDV in the eye: neoplasia or autoimmunity?. In: Parcells M.S., Morgan R.W., Burnside J., et al. (Eds). Proceedings of the 4th International Workshop on the molecular pathogenesis of Marek's disease. University of Delaware (2006) p16
61. Gimeno I.M., Witter R.L., Hunt H.D., Lee L.F., Reddy S.M., and Neumann U. Chronological study of brain alterations induced by a very virulent plus (vv+) strain of Marek's disease virus (MDV). In: Schat K.A., Morgan R.W., Parcells M.S., and Spencer J.L. (Eds). Proceedings of the 6th international symposium on Marek's disease. American Association of Avian Pathologists, Kennett Square, PA (2001) 21-26
62. Jarosinski K.W., Yunis R., O'Connell P.H., Markowski-Grimsrud C.J., and Schat K.A. Influence of genetic resistance of the chicken and virulence of Marek's disease virus (MDV) on nitric oxide responses after MDV infection. Avian Dis 46 (2002) 636-649
63. Jarosinski K.W., Njaa B.L., O'Connell P.H., and Schat K.A. Pro-inflammatory responses in chicken spleen and brain tissues after infection with very virulent plus Marek's disease virus. Viral Immunol 18 (2005) 148-161
64. Abdul-Careem M.F., Hunter B.D., Sarson A.J., Mayameei A., Zhou H., and Sharif S. Marek's disease virus-induced transient paralysis is associated with cytokine gene expression in the nervous system. Viral Immunol 19 2 (2006) 167-176
65. Eidson C.S., Fletcher O.J., Kleven S.H., and Anderson D.P. Detection of Marek's disease antigen in feather follicle epithelium of chickens vaccinated against Marek's disease. J Natl Cancer Inst 47 (1971) 113-120
66. Cho B.R. Dual virus maturation of both pathogenic and apathogenic Marek's disease herpesvirus (MDHV) in the feather follicles of dually infected chickens. Avian Dis 21 (1977) 501-507
67. Burgess S.C., Young J.R., Baaten B.J., Hunt L., Ross L.N., Parcells M.S., et al. Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30). Proc Natl Acad Sci USA 101 38 (2004) 13879-13884
68. Delecluse H.J., and Hammerschmidt W. Status of Marek's disease virus in established lymphoma cell lines: herpesvirus integration is common. J Virol 67 (1993) 82-92
69. Burgess S.C., and Davison T.F. Identification of the neoplastically transformed cells in Marek's disease herpesvirus-induced lymphomas: recognition by the monoclonal antibody AV37. J Virol 76 (2002) 7277-7292
70. Kawamura H., King D.J.J., and Anderson D.P. A herpesvirus isolated from kidney cell culture of normal turkeys. Avian Dis 13 (1969) 853-863
71. Witter R.L., Nazerian K., Purchase H.G., and Burgoyne G.H. Isolation from turkeys of a cell-associated herpesvirus antigenically related to Marek's disease virus. Am J Vet Res 31 (1970) 525-538
72. Prasad L.B.M. Effect of maternal antibody on viraemic and antibody responses to cell associated and cell free turkey herpesvirus in chickens. Br Vet J 134 (1978) 315-321
73. Witter R.L., and Burmester B.R. Differential effect of maternal antibodies on efficacy of cellular and cell-free Marek's disease vaccines. Avian Pathol 8 (1979) 145-156
74. Biggs P.M., and Milne B.S. Biological properties of a number of Marek's disease virus isolates. In: Biggs P.M., de-The G., and Payne L.N. (Eds). Oncogenesis and herpesviruses (1972), International Agency for Research on Cancer, Lyon, France 88-94
75. Zander D.V., Hill R.W., Raymond R.G., Balch R.K., Mitchell R.W., and Dunsing J.W. The use of blood from selected chickens as an immunizing agent for Marek's disease. Avian Dis 16 (1972) 163-178
76. Bülow V.V., Biggs P.M., and Frazier J.A. Characterization of a new serotype of Marek's disease herpesviruses. In: de-The G., et al. (Ed). Oncogenesis and herpesviruses II (1975), IARC Scientific Publications, Lyon 317-328
77. Schat K.A., and Calnek B.W. Characterization of an apparently nononcogenic Marek's disease virus. J Natl Cancer Inst 60 (1978) 1075-1082
78. Witter R.L., and Lee L.F. Polyvalent Marek's disease vaccines: safety, efficacy and protective synergism in chickens with maternal antibodies. Avian Pathol 13 (1984) 75-92
79. Churchill A.E., Chubb R.C., and Baxendale W. The attenuation with loss of oncogenicity of the herpes-type virus of Marek's disease (strain HPRS-16) on passage in cell culture. J Gen Virol 4 (1969) 557-564
80. Nazerian K. Attenuation of Marek's disease virus and study of its properties in two different cell cultures. J Natl Cancer Inst 44 (1970) 1257-1267
81. Meulemans G., Halen P., Schyns P., and Bruynooshe D. Field trials with an attenuated Marek's disease vaccine. Vet Rec 89 (1971) 325-329
82. Vielitz E., and Landgraf H. Vaccination tests against Marek's disease by application of an attenuated Marek herpes virus and a herpes virus of turkeys. Dtsch Tierarztl Wochenschr 78 (1971) 617-623
83. Spencer J.L., Grunder A.A., Robertson A., and Speckmann G.W. Attenuated Marek's disease herpesvirus: protection conferred on strains of chickens varying in genetic resistance. Avian Dis 16 (1972) 94-107
84. Witter R.L. Protection by attenuated and polyvalent vaccines against highly virulent strains of Marek's disease virus. Avian Pathol 11 (1982) 49-62
85. Rispens B.H., Van Vloten J., Mastenbroek N., Maas H.J.L., and Schat K.A. Control of Marek's disease in the Netherlands. I. Isolation of an avirulent Marek's disease virus (strain CVI 988) and its use in laboratory vaccination trials. Avian Dis 16 (1972) 108-125
86. Witter R.L., and Kreager K.S. Serotype 1 viruses modified by backpassage or insertional mutagenesis: approaching the threshold of vaccine efficacy in Marek's disease. Avian Dis 48 4 (2004) 768-782
87. Witter R.L. Protective efficacy of Marek's disease vaccines. In: Hirai K. (Ed). Current topics in microbiology and immunology (2001), Springer-Verlag, Berlin 58-90
88. Okazaki W., Purchase H.G., and Burmester B.R. Protection against Marek's disease by vaccination with a herpesvirus of turkeys. Avian Dis 14 (1970) 413-429
89. Schat K.A., Calnek B.W., and Fabricant J. Characterization of two highly oncogenic strains of Marek's disease virus. Avian Pathol 11 (1982) 593-605
90. Witter R.L., Li D., Jones D., Lee L.F., and Kung H.J. Retroviral insertional mutagenesis of a herpesvirus: a Marek's disease virus mutant attenuated for oncogenicity but not for immunosuppression or in vivo replication. Avian Dis 41 2 (1997) 407-421
91. Witter R.L. Influence of serotype and virus strain on synergism between Marek's disease vaccine viruses. Avian Pathol 21 (1992) 601-614
92. Pruthi A.K., Gupta R.K.P., and Sadana J.R. Efficacy of bivalent vaccine against Marek's disease. Res Vet Sci 42 (1987) 145-149
93. Nazerian K., Witter R.L., Lee L.F., and Yanagida N. Protection and synergism by recombinant fowl pox vaccines expressing genes from Marek's disease virus. Avian Dis 40 2 (1996) 368-376
94. Morgan R.W., Gelb Jr. J., Schreurs C.S., Lutticken D., Rosenberger J.K., and Sondermeijer P.J.A. Protection of chickens from Newcastle and Marek's diseases with a recombinant herpesvirus of turkeys vaccine expressing the Newcastle disease virus fusion protein. Avian Dis 36 (1992) 858-870
95. Morgan R.W., Gelb Jr. J., Pope C.R., and Sondermeijer P.J.A. Efficacy in chickens of a herpesvirus of turkeys recombinant vaccine containing the fusion gene of Newcastle disease virus: onset of protection and effect of maternal antibodies. Avian Dis 37 (1993) 1032-1040
96. Darteil R., Bublot M., Laplace E., Bouquet J.F., Audonnet J.C., and Riviere M. Herpesvirus of turkey recombinant viruses expressing infectious bursal disease virus (IBDV) VP2 immunogen induce protection against an IBDV virulent challenge in chickens. Virology 211 2 (1995) 481-490
97. Heckert R.A., Riva J., Cook S., McMillen J.K., and Schwartz R.D. Onset of protective immunity in chicks after vaccination with a recombinant herpesvirus of turkeys vaccine expressing Newcastle disease virus fusion and hemagglutinin-neuraminidase antigens. Avian Dis 40 (1996) 770-777
98. Cronenberg A.M., Van Geffen C.E.H., Dorrestein J., Vermeulen A.N., and Sondermeijer P.J.A. Vaccination of broilers with HVT expressing an Eimeria acervulina antigen improves performance after challenge with Eimeria. Acta Virol 43 2/3 (1999) 192-197
99. Nakamura H., Sakaguchi M., Hirayama Y., Miki N., Yamamota M., and Hirai K. Protection against Newcastle disease by recombinant Marek's disease virus serotype-1 expressing the fusion protein of Newcastle disease virus. Proceedings of the 4th international symposium on Marek's disease, 19th World's poultry congress, vol. 1. World's Poultry Science Association, Amsterdam (1992) 332-335
100. Sakaguchi M., Nakamura H., Sonoda K., Hamada F., and Hirai K. Protection of chickens from Newcastle disease by vaccination with a linear plasmid DNA expressing the F protein of Newcastle disease viru. Vaccine 14 (1996) 747-752
101. Schat K.A., Omar A.R., Lee L.F., and Hunt H.D. Induction of glycoprotein B (gB)-specific cytotoxic T cells after vaccination with recombinant fowl poxvirus expressing gB. In: Silva R.F., Cheng H.H., Coussens P.M., Lee L.F., and Velicer L.F. (Eds). Current research on Marek's disease (1996), American Association of Avian Pathologists Inc., Kennett Square, PA 432-435
102. Reddy S.K., Sharma J.M., Ahmad J., Reddy D.N., McMiller J.K., Cook S.M., et al. Protective efficacy of a recombinant herpesvirus of turkeys as an in ovo vaccine against Newcastle and Marek's diseases in specific pathogen-free chickens. Vaccine 14 6 (1996) 469-477
103. Lee L.E., Witter R.L., Reddy S.M., Wu P., Yanagida N., and Yoshida S. Protection and synergism by recombinant fowl pox vaccines expressing multiple genes from Marek's disease virus. Avian Dis 47 3 (2003) 549-558
104. Zelnik V., Tyers P., Smith G.D., Jiang C.L., and Ross L.J.N. Structure and properties of a herpesvirus of turkeys recombinant in which US1, US10 and SORF3 genes have been replaced by a lacZ expression cassette. J Gen Virol 76 (1995) 2903-2907
105. Morgan R.W., Kent J., and Anderson A.S. Marek's disease virus gC and meq mutants with dramatic reductions in tumour incidences and horizontal transmission. Avian Pathol 27 (1998) S89-S90
106. Cui X., Lee L.F., Hunt H.D., Reed W.M., Lupiani B., and Reddy S.M. A Marek's disease virus vIL-8 deletion mutant has attenuated virulence and confers protection against challenge with a very virulent plus strain. Avian Dis 49 2 (2005) 199-206
107. Lupiani B., Lee L.F., Cui X., Gimeno I.M., Anderson A., Morgan R.W., et al. Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication. Proc Natl Acad Sci USA 101 32 (2004) 11815-11820
108. Lee L.F., Reddy S.M., and Kreager K. Recombinant Marek' disease virus lacking the oncogene Meq as a candidate for future control of Marek's disease in chickens. Proceedings of the AVMA. Washington (2007)
109. Brown A.C., Baigent S.J., Smith L.P., Chattoo J.P., Petherbridge L.J., Hawes P., et al. Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus. Proc Natl Acad Sci USA 103 6 (2006) 1687-1692
110. St Hill C.A., and Sharma J.M. Viral pathogenesis in chicken embryos and tumor induction in chickens after in ovo exposure to serotype 1 Marek's disease virus. Avian Dis 44 4 (2000) 842-852
111. Zhang Y., and Sharma J.M. Early posthatch protection against Marek's disease in chickens vaccinated in ovo with a CVI988 serotype 1 vaccine. Avian Dis 45 3 (2001) 639-645
112. Payne L.N., Powell P.C., Rennie M., and Ross L.J.N. Studies on the mechanism of vaccinal immunity to Marek's disease. Proceedings of the 3rd International on World Assoc. Vet. Immunol. and Spec. (1976)
113. Schat K.A., and Calnek B.W. Demonstration of Marek's disease tumor associated surface antigen in chickens infected with nonocogenic Marek's disease virus and herpesvirus of turkeys. J Natl Cancer Inst 61 (1978) 855-857
114. Burgess S.C., Kaiser P., and Davison T.F. A novel lymphoblastoid surface antigen and its role in Marek's disease (MD). In: Silva R.F., Cheng H.H., Coussens P.M., Lee L.F., and Velicer L.F. (Eds). Current Research on Marek's Disease (1996), American Association of Avian Pathologists, Kennett Square, PA 29-39
115. Heller E.D., and Schat K.A. Enhancement of natural killer cell activity by Marek's disease vaccines. Avian Pathol 16 (1987) 51-60
116. Gimeno I.M., Witter R.L., Hunt H.D., Reddy S.M., and Reed W.M. Biocharacteristics shared by highly protective vaccines against Marek's disease. Avian Pathol 33 1 (2004) 59-68
117. Djeraba A., Musset E., Lowenthal J.W., Boyle D.B., Chausse A.M., Peloille M., et al. Protective effect of avian myelomonocytic growth factor in infection with Marek's disease virus. J Virol 76 3 (2002) 1062-1070
118. Tarpey I., Davis P.J., Sondermeijer P.J.A., van Geffen C., Verstegen I., Schijins V.E., et al. Expression of chicken interleukin-2 by turkey herpesvirus increases the immune response against Marek's disease virus but fails to increase protection against virulent challenge. Avian Pathol 36 1 (2007) 69-74
119. Onuma M., Mikami T., Hayashi T.T.A., and Fujimoto Y. Studies of Marek's disease herpesvirus and turkey herpesvirus specific common antigen which stimulates the production of neutralizing antibodies. Arch Virol 48 (1975) 85-98
120. Ikuta K., Nakajima K., Ueda S., Kato S., and Hirai K. Studies on the serological cross-reaction between Marek's disease virus and herpesvirus of turkeys using monoclonal antibodies to major virus-specific polypeptides. Arch Virol 81 (1984) 337-343
121. Uni Z., Pratt W.D., Miller M.M., O'Connell P.H., and Schat K.A. Syngeneic lysis of reticuloendotheliosis virus-transformed cell lines transfected with Marek's disease virus genes by virus-specific cytotoxic T cells. Vet Immunol Immunopathol 44 (1994) 57-69
122. Omar A.R., and Schat K.A. Characterization of Marek's disease virus (MDV)-specific cytotoxic T cells in chickens inoculated with an nononcogenic vaccine strain of MDV. In: Silva R.F., Cheng H.H., Coussens P.M., Lee L.F., and Velicer L.F. (Eds). Current research on Marek's disease (1996), American Association of Avian Pathologists Inc., Kennett Square, PA 20-22
123. Omar A.R., Schat K.A., Lee L.F., Hunt H.D., and Cytotoxic. T lymphocyte response in chickens immunized with a recombinant fowlpox virus expressing Marek's disease herpesvirus glycoprotein B. Vet Immunol Immunopathol 62 1 (1998) 73-82
124. Djeraba A., Musseet E., Bernardet N., Le Vern Y., and Quéré P. Similar pattern of iNOS expression, NO production and cytokine response in genetic and vaccination-acquired resistance to Marek's disease. Vet Immunol Immunopathol 85 1/2 (2002) 63-75
125. Abdul-Careem M.F., Hunter B.D., Parvizi P., Haghighi H.R., Thanthrige-Don N., and Sharif S. Cytokine gene expression patterns associated with immunization against Marek's disease in chickens. Vaccine (August 22, 2006)
126. Witter R.L. The path to a better vaccine for Marek's disease. Proceedings of the XV WVPA. Beijing (2007)
127. Silva R.F., El-Galil El-Gohary A.A., and Dunn J. The effect of vaccination on Marek's disease virus shedding. Proceedings of the 144th AVMA convention. Washington (2007)
128. Heidari M., Fitzgerald S.D., Zhang C.H.M., Silva R.F., Lee L.F., and Dunn J.R. Marek's disease virus-induced skin leukosis in scaleless chickens: tumor development in the absence of feather follicles. Avian Dis 51 3 (2007) 713-718
129. Stanberry L.R., Cunningham A.L., Mindel A., Scott L.L., Spruance S.L., Aoki F.Y., et al. Prospects for control of herpes simplex virus disease through immunization. Clin Infect Dis 30 3 (2000) 549-566
130. Klein R.J., Kaley L.A., and Friedman-Kien A.E. Protection against establishment of latent infections in mice immunized with a non-pathogenic herpes simplex virus mutant and reinfected with the pathogenic parental strain. Vaccine 2 (1984) 219-223
131. McDonald M.R., Li X.Y., Stenberg R.M., Campbell A.E., and Virgin H.W. Mucosal and parenteral vaccination against acute and latent murine cytomegalovirus (MCMV) infection by using an attenuated mutant. J Virol 72 (1998) 442-451
132. Tibbetts S.A., McClellan J.S., Gangappa S., Speck S.H., and Virgin H.W. Effective vaccination against long-term gammaherpesvirus latency. J Virol 77 (2003) 2522-2529
133. Ball R.F., and Lyman J. Revaccination of chicks for Marek's disease at twenty-one days old. Avian Dis 21 (1977) 440-444
134. de Boer G.F., Groenendal J.E., Boerrigter H.M., Kok G.L., and Pol J.M.A. Protective efficacy of Marek's disease virus (MDV) CVI-988 CEF65 clone C against challenge infection with three very virulent MDV strains. Avian Dis 30 (1986) 276-283
135. 2 intercross chickens. Genetics 148 1 (1998) 349-360
136. Bumstead N. Genomic mapping of resistance to Marek's disease. Avian Pathol 27 (1998) S78-S81
137. McElroy J.P., Dekkers J.C., Fulton J.E., O'Sullivan N.P., Soller M., Lipkin E., et al. Microsatellite markers associated with resistance to Marek's disease in commercial layer chickens. Poult Sci 84 11 (2005) 1678-1688
138. Liu H.-C., Cheng H.H., Sofer L., and Burnside J. Identification of genes and pathways for resistance to Marek's disease through DNA microarrays. In: Schat K.A., Morgan R.W., Parcells M.S., and Spencer J.L. (Eds). Proceedings of the 6th international symposium on Marek's disease. American Association of Avian Pathologists, New Bolton Center, PA (2001) 157-162
139. Liu H.-C., Kung H.J., Fulton J.E., Morgan R.M., and Cheng H.H. Growth hormone interacts with the Marek's disease virus SORF2 protein and is associated with disease resistance in chicken. PNAS 98 16 (2001) 9203-9208
140. Niikura M., Liu H.C., Dodgson J.B., and Cheng H.H. A comprehensive screen for chicken proteins that interact with proteins unique to virulent strains of Marek's disease virus. Poult Sci 83 7 (2004) 1117-1123
141. Crittenden L.B., and Salter D.W. A transgene, alv6, that expresses the envelope of subgroup a avian leukosis virus reduces the rate of congenital transmission of a field strain of avian leukosis virus. Poult Sci 71 (1992) 799-806
142. Johnson R.M., and Spear P.G. Herpes simplex virus glycoprotein D mediates interference with herpes simplex virus infection. J Virol 63 (1989) 819-827
143. Anderson A.S., Parcells M.S., and Morgan R.W. The glycoprotein D (US6) homolog is not essential for oncogenicity or horizontal transmission of Marek's disease virus. J Virol 72 3 (1998) 2548-2553
144. Whittaker G.R., Bonass W.A., Elton D.M., Halliburton I.W., Killington R.A., and Meredith D.M. Glycoprotein 300 is encoded by gene 28 of equine herpesvirus type 1: a new family of herpesvirus membrane proteins?. J Gen Virol 73 (1992) 2933-2940
145. Lee L.F., Wu P., and Sui D. Identification and transcriptional analysis of a Marek's disease virus gene encoding membrane glycoprotein gp82. In: Silva R.F., Cheng H.H., Coussens P.M., Lee L.F., and Velicer L.F. (Eds). Current research on Marek's disease (1996), American Association of Avian Pathologists Inc., Kennett Square, PA 245-250
146. Jarosinski K.W., Margulis N.G., Kamil J.P., Spatz S.J., Nair V.K., and Osterrieder N. Horizontal transmission of Marek's disease virus requires US2, the UL13 protein kinase, and gC. J Virol 81 19 (2007) 10575-10587
147. McCaffrey A.P., and Kay M.A. A story of mice and men. Gene Ther 9 (2002) 1563
148. Burnside J., Bernberg E., Anderson A., Lu C., Meyers B.C., Green P.J., et al. Marek's disease virus encodes MicroRNAs that map to meq and the latency-associated transcript. J Virol 80 17 (2006) 8778-8786
149. Yao Y., Zhao Y., Xu H., Smith L.P., Lawrie C.H., Sewer A., Zavolan M., and Nair V. Marek's disease virus type 2 (MDV-2)-encoded microRNAs show no sequence conservation with those encoded by MDV-1. J Virol 81 13 (2007) 7164-7170
150. Lois C., Hong E.J., Pease S., Brown E.J., and Baltimore D. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295 (2002) 868-872