LRRK2 MUTATION ANALYSIS IN PARKINSON DISEASE FAMILIES WITH EVIDENCE OF LINKAGE TO PARK8

Neurology

Volumn 70, Issue 24, 2008, Pages 2348-2349

  Bonifati, V ^a   Wu Chou, Y H ^a   Schweiger, D ^a   Fonzo, A Di ^a   Lu, C S ^a   Oostra, B ^a  

^a NONE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE RICH REPEAT KINASE 2; LRRK2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

FAMILY STUDY; FRAMESHIFT MUTATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; HUMAN; LETTER; LOSS OF FUNCTION MUTATION; NONSENSE MUTATION; PARKINSON DISEASE; PRIORITY JOURNAL; RISK FACTOR; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MUTATION; NOTE; NUCLEOTIDE SEQUENCE;

DNA MUTATIONAL ANALYSIS; GENETIC PREDISPOSITION TO DISEASE; LINKAGE (GENETICS); MUTATION; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES;

EID: 46049084847     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/01.wnl.0000317005.06662.01     Document Type: Letter

References (4)

1. Nichols WC, Elsaesser VE, Pankratz N, et al. LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8. Neurology 2007;69:1737-1744.
2. Di Fonzo A, Wu-Chou YH, Lu CS, et al. A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson’s disease risk in Taiwan. Neurogenetics 2006;7:133-138.
3. Bonifati V. LRRK2 Low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)-linking familial and sporadic Parkinson’s disease. Neurochem Res 2007;32:1700-1708.
4. Lee SB, Kim W, Lee S, Chung J. Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila. Biochem Biophys Res Commun 2007;358:534-539.